Effect of Gut Dysbiosis on Onset of GI Cancer DOI Open Access
Seema Kumari, Mundla Srilatha, Ganji Purnachandra Nagaraju

и другие.

Cancers, Год журнала: 2024, Номер 17(1), С. 90 - 90

Опубликована: Дек. 30, 2024

Dysbiosis in the gut microbiota plays a significant role GI cancer development by influencing immune function and disrupting metabolic functions. can drive carcinogenesis through pathways like dysregulation release of carcinogenic metabolites, altered metabolism, genetic instability, pro-inflammatory signalling, contributing to initiation progression. Helicobacter pylori infection genotoxins released from dysbiosis, lifestyle dietary habits are other factors that contribute development. Emerging diagnostic therapeutic approaches show promise colorectal treatment, including multitarget faecal immunochemical test (mtFIT), standard FIT, transplantation (FMT) combined with PD-1 inhibitors. We used search engine databases PubMed, Scopus, Web Science. This review discusses dysbiosis onset explores strategies such as FMT, probiotics, prebiotics enhance response improve therapy outcomes.

Язык: Английский

Endometriosis and autoimmunity DOI

Luz P. Blanco,

Noemi Salmeri, Sarah M. Temkin

и другие.

Autoimmunity Reviews, Год журнала: 2025, Номер unknown, С. 103752 - 103752

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

6
Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products DOI Creative Commons
Dongyang Li, Xingguo Lan,

Linyi Xu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 24, 2025

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.

Язык: Английский

Процитировано

1
Beyond the skin: endocrine, psychological and nutritional aspects in women with hidradenitis suppurativa DOI Creative Commons
Anna Dattolo, Mónica Torres Sánchez, Evelyn Frías-Toral

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 10, 2025

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disorder that primarily affects body folds and the genital area, with higher prevalence in women across Europe. The pathogenesis of HS involves complex interplay intrinsic extrinsic factors, including genetics, immunity, hormones, environmental influences. frequently associated variety comorbidities, such metabolic, endocrine, gastrointestinal conditions, well mental health disorders. Although symptoms are generally similar both men women, female patients may experience exacerbations due to hormonal fluctuations during menstruation, pregnancy, breastfeeding, menopause. These changes require special consideration by clinicians when managing women. Due its nature frequent flare-ups, significantly impacts patients' quality life, affecting social interactions, emotional well-being, psychological health. Women sexual dysfunction, which further exacerbated burdens shame, loss femininity, diminished intimacy. This review highlights key aspects HS, extending beyond manifestations address psychological, nutritional population. It underscores importance multidisciplinary collaboration providing comprehensive care for this debilitating condition. Given limited largely off-label treatment options, holistic approach essential ensure an appropriate management.

Язык: Английский

Процитировано

0
Associations of Dietary Index for Gut Microbiota and Flavonoid Intake With Female Infertility in the United States DOI Creative Commons
Di Xiao, Xiang Sun, Weidong Li

и другие.

Food Science & Nutrition, Год журнала: 2025, Номер 13(4)

Опубликована: Март 26, 2025

This study aimed to investigate the associations between a dietary index for gut microbiota (DI-GM), flavonoid intake, and female infertility, while exploring age-specific differences in these relationships identify potential strategies infertility prevention. cross-sectional focused on participants aged 18-45 years, with data obtained from 2017-2018 cycle of National Health Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models were employed examine DI-GM, self-reported infertility. Age-stratified analyses performed evaluate whether varied across reproductive life stages. Higher DI-GM scores significantly associated reduced risk (aOR = 0.30, 95% CI: 0.13-0.71, p 0.006), strongest protective effects observed women < 35 years (Q3: aOR 0.13, 0.03-0.58, 0.007; Q4: 0.27, 0.09-0.77, 0.015). Beneficial also showed effect 0.75, 0.57-0.98, 0.036). Among ≥ moderate intake (Q2) significant inverse association 0.19, 0.06-0.66, 0.009). Our findings reveal novel evidence that higher are linked lower patterns observed. younger (< years), was years. These underscore personalized targeting composition as cost-effective approaches prevention management different

Язык: Английский

Процитировано

0
Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer DOI Creative Commons
Hussein Sabit,

Sama Abouelnour,

Bassel M. Hassen

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 990 - 990

Опубликована: Апрель 18, 2025

Estrogen receptors (ERs) play a critical role in breast cancer (BC) development and progression, with ERα being oncogenic ERβ exhibiting tumor-suppressive properties. The interaction between ER signaling other molecular pathways, such as PI3K/AKT/mTOR, influences tumor growth endocrine resistance. Emerging research highlights the of prebiotics modulating gut microbiota, which may influence estrogen metabolism, immune function, therapeutic responses BC. This review explores impact on receptor modulation, microbiota composition, regulation, metabolic pathways cancer. potential adjunctive therapies to enhance treatment efficacy mitigate chemotherapy-related side effects is discussed. A comprehensive analysis recent preclinical clinical studies was conducted, examining reprogramming short-chain fatty acids (SCFAs) derived from prebiotic fermentation epigenetic regulation resistance also evaluated. Prebiotics were found modulate microbiota-estrogen axis, reduce inflammation, responses. SCFAs demonstrated selective downregulation reprogramming, suppressing growth. Synbiotic interventions effects, improving quality life patients. offer promising avenue for prevention therapy by pathways. Future trials are needed validate their treatments management.

Язык: Английский

Процитировано

0
Gut microbiota and hyperbaric oxygen therapy DOI

Daisuke Muroya,

Shinya Nadayoshi,

Yutaro Kai

и другие.

Medical Gas Research, Год журнала: 2025, Номер 15(4), С. 548 - 549

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0
Moxibustion Enhances Ovarian Function by Inhibiting the Th17/IL‐17 Pathway and Regulating Gut Microbiota in POI Rats DOI
Cai-Rong Zhang,

Xinru Lu,

Tianyi Zhang

и другие.

American Journal of Reproductive Immunology, Год журнала: 2025, Номер 93(5)

Опубликована: Май 1, 2025

ABSTRACT Problem Premature ovarian insufficiency (POI) is a significant cause of female infertility, severely impacting physical and mental health. Current treatments, primarily hormone replacement therapy, fail to restore function may adverse effects. Moxibustion, traditional Chinese medicine has shown potential in treating POI, but its mechanisms remain unclear. This study investigated the therapeutic effects moxibustion on POI rats explored underlying mechanisms. Method Study A rat model was established using cyclophosphamide, applied daily CV4 SP6 acupoints for 4 weeks. We analyzed levels, estrous cycles, follicle count, gut microbiota. Transcriptomic metagenomic sequencing were performed identify pathways. Network pharmacology used predict active components targets. Results Moxibustion restored improved hormonal imbalances, increased reserve function. identified five moxa, based results network transcriptome sequencing, we believe that regulation IL‐17 pathway key mechanism. Further experiments showed downregulated Th17/IL‐17 pathway, reduced proteins such as IL‐17R, NF‐κB, MMP3, IκBα, IL‐1β, MMP9, TRAF6, Cox2. Flow cytometry confirmed decrease Th17 cell proportion. Gut microbiota analysis revealed enhanced microbial diversity modulated specific bacterial species, which correlated with levels. Conclusion effect by regulating Th17/IL17 microbiota, provides evidence clinical application moxibustion.

Язык: Английский

Процитировано

0
Association between endometriosis and gut microbiota: systematic review and meta-analysis DOI Creative Commons
Yuanyue Li,

Ouyang Dimei,

Ling Liu

и другие.

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Май 7, 2025

Endometriosis, a complex gynecological disorder, has been increasingly linked to gut microbiota dysbiosis, suggesting its potential role in disease pathogenesis. This systematic review and meta-analysis explore the association between endometriosis by evaluating alpha beta diversity measures across 11 studies involving 1,727 women, including 433 diagnosed with 1,294 controls. Statistical analysis was performed utilizing either random effects models or fixed Revmen5.2 STATA softwares. Significant differences control groups were observed using Shannon Index (SMD = 0.39; p < 0.00001), Subgroup showed significant for Chinese 0.48; 95% CI 0.14 0.82; 0.006; I 2 30%), Swedish, 0.55; 0.27 0.83; 0.0001; 30%) Spanish 0.34; -0.02 0.85; 0.06; 27%), compared others which highlighting correlation different demographic groups. The Simpson also revealed notable difference richness 0.91; 0.03). However, no detected Chao 0.37; 0.11). These findings underscore importance of understanding microbiota's endometriosis. Seven employed PCoA, two used Bray-Curtis dissimilarity index, one PCA, revealing dissimilarities composition Using Newcastle-Ottawa Scale, most scored ≥7 stars, indicating high quality. funnel plot Egger's linear regression indicated publication bias. study highlights alterations women endometriosis, emphasizing Future research should focus on standardizing reporting methods facilitate deeper quantitative analyses. PROSPERO (registration number RD42024611701).

Язык: Английский

Процитировано

0
Pueraria: A Comprehensive Review of Chemical Composition, Health Benefits, and Current Applications DOI
Qiong Wu, Kai Chen, Yaru Li

и другие.

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(3)

Опубликована: Май 1, 2025

ABSTRACT Pueraria as a legume vine is mainly produced in East Asia and Southeast Asia. Its most widely used part the tuber. often to treat various diseases such fever headache since ancient times. Recently, pueraria valuable source of polysaccharides, phytochemicals, proteins, minerals, other nutrients has anticancer, immunomodulatory, hypoglycemic, lipid‐lowering, antiatherosclerotic, neuroprotective, hepatointestinal regulatory, hormonal regulatory activities, so forth. This review provides comprehensive overview resources distribution, processing procedures application, nutritional phytochemical composition, biological activities pueraria, gives insights into developing potential novel ingredient for its versatile food nonfood applications along with latest researches conducted worldwide. Furthermore, it highlights safety issues consumption ingredient.

Язык: Английский

Процитировано

0
The ovarian cancer-associated microbiome contributes to the tumor’s inflammatory microenvironment DOI Creative Commons
Min Zhang, Jiahang Mo, Wu Huang

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Окт. 21, 2024

A growing body of research has established a correlation between tumors and persistent chronic inflammatory infiltration. As primary instigator inflammation, the majority microbiomes naturally residing within our bodies engage in mutually beneficial symbiotic relationship. Nevertheless, alterations microbiome's composition or breaches normal barrier function can disrupt internal environment's homeostasis, potentially leading to development progression various diseases, including tumors. The investigation tumor-related contributed deeper understanding their role tumorigenesis. This review offers comprehensive overview microbiome associated changes ovarian cancer. It may aid advancing elucidate mechanisms underlying cancer-associated microbiome, providing potential theoretical support for future microbiome-targeted antitumor therapies early screening through convenient methods.

Язык: Английский

Процитировано

2