Effect of Gut Dysbiosis on Onset of GI Cancer DOI Open Access
Seema Kumari, Mundla Srilatha, Ganji Purnachandra Nagaraju

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 90 - 90

Published: Dec. 30, 2024

Dysbiosis in the gut microbiota plays a significant role GI cancer development by influencing immune function and disrupting metabolic functions. can drive carcinogenesis through pathways like dysregulation release of carcinogenic metabolites, altered metabolism, genetic instability, pro-inflammatory signalling, contributing to initiation progression. Helicobacter pylori infection genotoxins released from dysbiosis, lifestyle dietary habits are other factors that contribute development. Emerging diagnostic therapeutic approaches show promise colorectal treatment, including multitarget faecal immunochemical test (mtFIT), standard FIT, transplantation (FMT) combined with PD-1 inhibitors. We used search engine databases PubMed, Scopus, Web Science. This review discusses dysbiosis onset explores strategies such as FMT, probiotics, prebiotics enhance response improve therapy outcomes.

Language: Английский

Endometriosis and autoimmunity DOI

Luz P. Blanco,

Noemi Salmeri, Sarah M. Temkin

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103752 - 103752

Published: Jan. 1, 2025

Language: Английский

Citations

4
Beyond the skin: endocrine, psychological and nutritional aspects in women with hidradenitis suppurativa DOI Creative Commons
Anna Dattolo, Mónica Torres Sánchez, Evelyn Frías-Toral

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 10, 2025

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disorder that primarily affects body folds and the genital area, with higher prevalence in women across Europe. The pathogenesis of HS involves complex interplay intrinsic extrinsic factors, including genetics, immunity, hormones, environmental influences. frequently associated variety comorbidities, such metabolic, endocrine, gastrointestinal conditions, well mental health disorders. Although symptoms are generally similar both men women, female patients may experience exacerbations due to hormonal fluctuations during menstruation, pregnancy, breastfeeding, menopause. These changes require special consideration by clinicians when managing women. Due its nature frequent flare-ups, significantly impacts patients' quality life, affecting social interactions, emotional well-being, psychological health. Women sexual dysfunction, which further exacerbated burdens shame, loss femininity, diminished intimacy. This review highlights key aspects HS, extending beyond manifestations address psychological, nutritional population. It underscores importance multidisciplinary collaboration providing comprehensive care for this debilitating condition. Given limited largely off-label treatment options, holistic approach essential ensure an appropriate management.

Language: Английский

Citations

0
Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products DOI Creative Commons
Dongyang Li, Xingguo Lan,

Linyi Xu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 24, 2025

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences efficacy have been observed clinical practice. There is increasing evidence that gut microbial metabolites influence distal via gut-liver axis, gut-brain axis and gut-breast a process may involve modulating expression immune cells cytokines microenvironment (TME). this review, we systematically explore relationship between immunotherapy, examine corresponding natural products their mechanisms action. The in-depth exploration research area will provide new ideas strategies to enhance mitigate adverse effects.

Language: Английский

Citations

0
Associations of Dietary Index for Gut Microbiota and Flavonoid Intake With Female Infertility in the United States DOI Creative Commons
Di Xiao, Xiang Sun, Weidong Li

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: March 26, 2025

This study aimed to investigate the associations between a dietary index for gut microbiota (DI-GM), flavonoid intake, and female infertility, while exploring age-specific differences in these relationships identify potential strategies infertility prevention. cross-sectional focused on participants aged 18-45 years, with data obtained from 2017-2018 cycle of National Health Nutrition Examination Survey (NHANES). Weighted multivariable logistic regression models were employed examine DI-GM, self-reported infertility. Age-stratified analyses performed evaluate whether varied across reproductive life stages. Higher DI-GM scores significantly associated reduced risk (aOR = 0.30, 95% CI: 0.13-0.71, p 0.006), strongest protective effects observed women < 35 years (Q3: aOR 0.13, 0.03-0.58, 0.007; Q4: 0.27, 0.09-0.77, 0.015). Beneficial also showed effect 0.75, 0.57-0.98, 0.036). Among ≥ moderate intake (Q2) significant inverse association 0.19, 0.06-0.66, 0.009). Our findings reveal novel evidence that higher are linked lower patterns observed. younger (< years), was years. These underscore personalized targeting composition as cost-effective approaches prevention management different

Language: Английский

Citations

0
Anticancer Potential of Prebiotics: Targeting Estrogen Receptors and PI3K/AKT/mTOR in Breast Cancer DOI Creative Commons
Hussein Sabit,

Sama Abouelnour,

Bassel M. Hassen

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 990 - 990

Published: April 18, 2025

Estrogen receptors (ERs) play a critical role in breast cancer (BC) development and progression, with ERα being oncogenic ERβ exhibiting tumor-suppressive properties. The interaction between ER signaling other molecular pathways, such as PI3K/AKT/mTOR, influences tumor growth endocrine resistance. Emerging research highlights the of prebiotics modulating gut microbiota, which may influence estrogen metabolism, immune function, therapeutic responses BC. This review explores impact on receptor modulation, microbiota composition, regulation, metabolic pathways cancer. potential adjunctive therapies to enhance treatment efficacy mitigate chemotherapy-related side effects is discussed. A comprehensive analysis recent preclinical clinical studies was conducted, examining reprogramming short-chain fatty acids (SCFAs) derived from prebiotic fermentation epigenetic regulation resistance also evaluated. Prebiotics were found modulate microbiota-estrogen axis, reduce inflammation, responses. SCFAs demonstrated selective downregulation reprogramming, suppressing growth. Synbiotic interventions effects, improving quality life patients. offer promising avenue for prevention therapy by pathways. Future trials are needed validate their treatments management.

Language: Английский

Citations

0
Gut microbiota and hyperbaric oxygen therapy DOI

Daisuke Muroya,

Shinya Nadayoshi,

Yutaro Kai

et al.

Medical Gas Research, Journal Year: 2025, Volume and Issue: 15(4), P. 548 - 549

Published: April 29, 2025

Language: Английский

Citations

0
The ovarian cancer-associated microbiome contributes to the tumor’s inflammatory microenvironment DOI Creative Commons
Min Zhang, Jiahang Mo, Wu Huang

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 21, 2024

A growing body of research has established a correlation between tumors and persistent chronic inflammatory infiltration. As primary instigator inflammation, the majority microbiomes naturally residing within our bodies engage in mutually beneficial symbiotic relationship. Nevertheless, alterations microbiome's composition or breaches normal barrier function can disrupt internal environment's homeostasis, potentially leading to development progression various diseases, including tumors. The investigation tumor-related contributed deeper understanding their role tumorigenesis. This review offers comprehensive overview microbiome associated changes ovarian cancer. It may aid advancing elucidate mechanisms underlying cancer-associated microbiome, providing potential theoretical support for future microbiome-targeted antitumor therapies early screening through convenient methods.

Language: Английский

Citations

1
Effect of Gut Dysbiosis on Onset of GI Cancer DOI Open Access
Seema Kumari, Mundla Srilatha, Ganji Purnachandra Nagaraju

et al.

Cancers, Journal Year: 2024, Volume and Issue: 17(1), P. 90 - 90

Published: Dec. 30, 2024

Dysbiosis in the gut microbiota plays a significant role GI cancer development by influencing immune function and disrupting metabolic functions. can drive carcinogenesis through pathways like dysregulation release of carcinogenic metabolites, altered metabolism, genetic instability, pro-inflammatory signalling, contributing to initiation progression. Helicobacter pylori infection genotoxins released from dysbiosis, lifestyle dietary habits are other factors that contribute development. Emerging diagnostic therapeutic approaches show promise colorectal treatment, including multitarget faecal immunochemical test (mtFIT), standard FIT, transplantation (FMT) combined with PD-1 inhibitors. We used search engine databases PubMed, Scopus, Web Science. This review discusses dysbiosis onset explores strategies such as FMT, probiotics, prebiotics enhance response improve therapy outcomes.

Language: Английский

Citations

0