European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(28)
Опубликована: Апрель 29, 2022
Abstract
The
copper‐catalyzed
oxidative
azide‐olefin
cycloaddition
(OAOC)
reaction
of
differently
substituted
α
,
β
‐unsaturated
carbonyls
with
azides
provided
an
efficient
method
for
preparing
biologically
active
1,4,5‐trisubstituted
1,2,3‐triazoles.
In
this
study,
the
was
found
to
be
a
simple
and
powerful
constructing
diverse
mono‐
bis‐(1,4,5‐trisubstituted
1,2,3‐triazole)
functionalized
heterocyclic
compounds
in
moderate
high
yields
great
regioselectivity.
XRD‐analysis
data
one
bis‐triazole
derivatives
supported
regioselectivity
as
well
conformity
construction
triazole
nucleus.
preliminary
antifungal
profile
against
C.
albicans
observed
cinnamaldehyde‐based
demonstrating
promising
results.
Current Organic Synthesis,
Год журнала:
2023,
Номер
21(4), С. 513 - 558
Опубликована: Апрель 19, 2023
Immediately
after
the
invention
of
'Click
Chemistry'
in
2002,
regioselective
1,2,3-
triazole
scaffolds
resulted
from
respective
organic
azides
and
terminal
alkynes
under
Cu(I)
catalysis
have
been
well
recognized
as
functional
heterocyclic
core
at
centre
modern
chemistry,
medicinal
material
sciences.
This
CuAAC
reaction
has
several
notable
features
including
excellent
regioselectivity,
high-to-excellent
yields,
easy
to
execute,
short
time,
modular
nature,
mild
condition,
readily
available
starting
materials,
etc.
Moreover,
resulting
triazoles
can
serve
amide
bond
isosteres,
a
privileged
group
drug
discovery
development.
More
than
hundreds
reviews
had
devoted
special
reference
1,4-disubstituted
triazoles,
while
only
little
efforts
were
made
for
an
opposite
regioisomer
i.e.,
1,5-disubstituted
triazole.
Herein,
we
presented
various
classical
approaches
expeditious
synthesis
wide
range
biologically
relevant
1,5-
disubstituted
1,2,3-triazole
analogues.
The
syntheses
such
class
diversly
functionalized
emerged
crucial
investigation
domain
chemistry
biology.
tutorial
review
covers
literature
assessment
on
development
synthetic
protocols
reported
during
last
12
years.
Advanced Synthesis & Catalysis,
Год журнала:
2022,
Номер
364(8), С. 1402 - 1408
Опубликована: Март 11, 2022
Abstract
A
metal‐free
three‐component
coupling
of
α‐CF
3
carbonyls,
azides
and
amines
for
the
regioselective
synthesis
1,4,5‐trisubstituted
1,2,3‐triazoles
in
air
is
established.
Various
substituted
4‐amide
were
obtained
when
enolizable
ketones
applied
aqueous
reaction
medium.
Control
18
O‐labelling
experiments
revealed
that
situ
generated
β‐oxo
amide
was
responsible
formal
oxygen‐shift
subsequent
[3+2]
cycloaddition
reaction,
with
amine
as
both
catalyst
reactant.
In
case
non‐enolizable
esters,
densely
functionalized
5‐amino
achieved
exclusively,
which
could
enable
late‐stage
functionalization
complex
biological
molecules.
magnified
image
Current Organic Synthesis,
Год журнала:
2022,
Номер
20(6), С. 630 - 662
Опубликована: Ноя. 22, 2022
Imidazoles
have
long
held
a
special
place
in
heterocyclic
chemistry,
and
their
derivatives
piqued
interest
recent
years
due
to
diverse
chemistry
pharmacology
features.
Imidazole
is
biologically
pharmaceutically
important
nitrogen-containing
ring.
As
result,
researchers
been
interested
imidazole
molecules.
For
century
half,
purine,
histamine,
other
natural
compounds
all
contained
the
A
number
of
drugs
prepared
marketed
for
treatment
various
diseases.
In
view
this,
we
herein
report
detailed
account
synthetic
procedures
drugs.
Russian Chemical Reviews,
Год журнала:
2025,
Номер
94(4), С. RCR5160 - RCR5160
Опубликована: Апрель 1, 2025
The
stereochemistry
of
tautomeric
functionalized
azoles
is
a
challenge
for
theoretical
research,
since
the
correct
interpretation
chemical
behaviour
and
biological
activity
these
compounds
depends
on
understanding
factors
that
determine
structural
features
relative
stability
their
tautomers.
Due
to
physicochemical
properties,
1,2,3-
1,2,4-triazoles
are
most
promising
research
objects
in
various
fields
ranging
from
medicine,
bioorganic
chemistry
agrochemistry
materials
science.
This
review
first
in-depth
analysis
data
structure
stereochemical
1,2,3-triazoles
(their
carbaldehydes,
carbaldehydoximes,
barbiturates
malononitriles),
model
analogues,
as
well
related
compounds,
obtained
by
combined
methods
based
multipulse
multinuclear
1H,
13C,
15N
29Si
NMR
spectroscopy
quantum
calculations.
<br>
bibliography
includes
320
references.
