Green Chemistry, Год журнала: 2023, Номер 25(15), С. 6041 - 6050
Опубликована: Янв. 1, 2023
An amine transaminase and a lipase have been immobilised in separated reactors containing EziG polymer-coated controlled porosity glass carrier materials to transform 1-phenoxypropan-2-one into the corresponding ( R )-acetamide organic solvent.
Язык: Английский
ChemistrySelect, Год журнала: 2025, Номер 10(1)
Опубликована: Янв. 1, 2025
Abstract Chiral substances play a pivotal role in numerous contemporary fields, and their synthesis heavily relies on chiral catalysts. However, traditional homogeneous catalysts suffer from significant drawbacks, including difficulty separation products nonrecyclability. Immobilization of onto specific carrier offers an excellent solution to these challenges, significantly reducing the production cost. Consequently, this approach has emerged as inevitable trend development This review comprehensively summarizes representative examples asymmetric catalytic reactions using immobilized inorganic carriers over last decade, classifies them according type carrier, elucidates loading techniques recycling methods associated with carriers.
Язык: Английский
Процитировано
1
Reaction Chemistry & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
In a previous communication, we described flow chemical microwave implementation, where the reaction mixture is circulated.
Язык: Английский
Процитировано
1
Organic Process Research & Development, Год журнала: 2022, Номер 26(8), С. 2190 - 2223
Опубликована: Июнь 14, 2022
Since the 1930s, fixed bed reactors (FBR) have been operated for continuous hydrogenation reactions in petrochemical/fine chemical industries, with publications each year detailing engineering principles, scientific breakthroughs, equipment design and setup, from these industries. Only last two decades, FBR started to be utilized pharmaceutical industry as a result of sustainability commitment growing demand complex specialized drugs. Most knowledge is transferable across industries; however, there are differentiators inherent industry, having its own unique challenges. One main between industries reactor scale and, consequently, catalyst requirements. Petrochemicals or fine chemicals operate on large industrial scale, up 72 m high reactors, an internal diameter order 5 (China Petroleum & Chemical Corporation), require volumes catalysts because product thousands tonnes per year, while smaller required kilograms range. It size that defines specifications, such particle geometry. Many transformations emerged academic medicinal chemistry groups utilizing ThalesNano H-Cube; relatively few reported processes scaled within industry. This Perspective outlines review flow technologies; focusing trickle (TBR) respective process operation effect variables reaction rate requirements industry; it also reflects transformation examples using TBR
Язык: Английский
Процитировано
29
Frontiers in Catalysis, Год журнала: 2023, Номер 3
Опубликована: Апрель 21, 2023
Flow biocatalysis is a key enabling technology that increasingly being applied to wide array of reactions with the aim achieving process intensification, better control biotransformations, and minimization waste stream. In this mini-review, selected applications flow preparation food ingredients, APIs fat- oil-derived commodity chemicals, covering period 2020-2022, are described.
Язык: Английский
Процитировано
13
Organic Process Research & Development, Год журнала: 2022, Номер 26(2), С. 422 - 430
Опубликована: Янв. 20, 2022
A continuous-flow preparation of 2-benzoxazolinone via the Hofmann rearrangement salicylamide has been implemented employing trichloroisocyanuric acid as stable and atom-economic chlorinating agent. The system was optimized to avoid solid accumulation allow hundreds grams pure desired material over a working day. Furthermore, (TCCA)-based chlorination 2-benzoxazolone corresponding 5-chloro derivative also carried out under batch conditions.
Язык: Английский
Процитировано
17
ACS Medicinal Chemistry Letters, Год журнала: 2023, Номер 14(3), С. 326 - 337
Опубликована: Фев. 3, 2023
The efficacy, safety, and scale-up of several chemical rearrangements remain unsolved problems due to the associated handling hazardous, toxic, pollutant chemicals high-risk intermediates. For many years batch processes have been considered only possibility drive these reactions, but continuous-flow technology has emerged, for both academic laboratories pharmaceutical companies, as a powerful tool easy, controlled, safer chemistry protocols, helping minimize formation side products increase reaction yields. This Technology Note summarizes recently reported using approaches, with focus on Curtius, Hofmann, Schmidt reactions. Flow general advantages safety aspects, scope generation privileged scaffolds active ingredients will be showcased.
Язык: Английский
Процитировано
10
Catalysis Science & Technology, Год журнала: 2023, Номер 13(8), С. 2308 - 2316
Опубликована: Янв. 1, 2023
Simple zeolites (NaY, NaX,…) catalyze the halogen switch between two different alkyl halides under either batch or flow reaction conditions. Sodalite cages are proposed to trigger transformation.
Язык: Английский
Процитировано
10
Sensors and Actuators B Chemical, Год журнала: 2024, Номер unknown, С. 136989 - 136989
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
4
Advanced Materials Technologies, Год журнала: 2024, Номер 9(14)
Опубликована: Май 16, 2024
Abstract Mechanochemistry has developed rapidly in recent years for efficient chemicals and materials synthesis. Twin screw extrusion (TSE) is a particularly promising technique this regard because of its continuous scalable nature. A key aspect TSE that it provides high shear mixing. Because the shear, potentially also offers way to delaminate 2‐D materials. Indeed, synthesis manor remains challenge their industrialization. Here, as proof‐of‐principle, automated, mechanochemical exfoliation graphite give multi‐layer graphene (MLG, ≈6 layers) by demonstrated. To achieve this, solid‐and‐liquid‐assisted (SLAE) process which organic additives such pyrene are rendered liquid due temperatures used, assist with exfoliation, simultaneously solid sodium chloride used grinding aid. This gave MLG yield (25 wt%) short residence time (8 min) notably negligible evidence structural deterioration (defects or oxidation).
Язык: Английский
Процитировано
3
Molbank, Год журнала: 2025, Номер 2025(1), С. M1969 - M1969
Опубликована: Фев. 19, 2025
A continuous flow process was optimised for the perchlorination of p-cresol to corresponding 2,4,6-trichloro-cyclohexa-2,5-dienone derivative employing trichloroisocyanuric acid as a green and safer-to-handle chlorinating agent. The system could furnish 200 g pure material within 5 h operation (throughput = 40 h−1). compound easily isolated by filtration obtained in 95% purity determined GC analysis; it be further purified crystallisation from 20:1 Hexane/AcOEt mixture left at −20 °C overnight. resultant product characterised 1H & 13C NMR, MS, IR analyses, with melting point X-ray single-crystal data being obtained, confirming structure.
Язык: Английский
Процитировано
0