The Impact and Evolution of COVID-19 on Liver Transplant Recipients Throughout the Pandemic “Waves” in a Single Center
Viruses,
Год журнала:
2025,
Номер
17(2), С. 273 - 273
Опубликована: Фев. 16, 2025
Liver
transplant
recipients
(LTRs)
have
been
considered
a
population
group
that
is
vulnerable
to
COVID-19
as
they
are
chronically
immunosuppressed
patients
with
frequent
comorbidities.
This
study
describes
the
course
of
SARS-CoV-2
disease
from
February
2020
December
2023
along
seven
pandemic
"waves".
We
carried
out
an
observational
on
307
cases
in
cohort
LTRs
aim
evaluating
changes
characteristics
over
time
and
determining
risk
factors
for
severe
COVID-19.
An
older
age
serum
creatinine
level
≥
2
mg/dL
were
found
be
hospital
admission
respiratory
failure.
The
use
calcineurin
inhibitors
was
protective
factor
death,
hospitalization,
failure
One
hundred
percent
who
died
(N
=
12)
mycophenolate
mofetil,
which
determinant
Azathioprine
associated
intensive
care
unit
(ICU)
invasive
mechanical
ventilation
(IMV).
Vaccination
failure,
mortality.
rate
higher
during
first
five
waves,
peak
57.14%,
highest
mortality
(21.43%)
occurred
fourth
wave.
IMV
ICU
rates
did
not
show
significant
differences
across
periods
studied.
Язык: Английский
A mid‑pandemic night's dream: Melatonin, from harbinger of anti‑inflammation to mitochondrial savior in acute and long COVID‑19 (Review)
International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
53(3)
Опубликована: Янв. 26, 2024
Coronavirus
disease
2019
(COVID‑19),
a
systemic
illness
caused
by
severe
acute
respiratory
distress
syndrome
2
(SARS‑CoV‑2),
has
triggered
worldwide
pandemic
with
symptoms
ranging
from
asymptomatic
to
chronic,
affecting
practically
every
organ.
Melatonin,
an
ancient
antioxidant
found
in
all
living
organisms,
been
suggested
as
safe
and
effective
therapeutic
option
for
the
treatment
of
SARS‑CoV‑2
infection
due
its
good
safety
characteristics
broad‑spectrum
antiviral
medication
properties.
Melatonin
is
essential
various
metabolic
pathways
governs
physiological
processes,
such
sleep‑wake
cycle
circadian
rhythms.
It
exhibits
oncostatic,
anti‑inflammatory,
anti‑aging
properties,
exhibiting
promise
use
numerous
disorders,
including
COVID‑19.
The
preventive
effects
melatonin
have
widely
explored
number
conditions
well‑established
experimental
ischemia/reperfusion
investigations,
particularly
coronary
heart
stroke.
Clinical
research
evaluating
COVID‑19
shown
improved
outcomes,
reduced
hospitalization
durations;
however,
trials
are
small.
can
alleviate
mitochondrial
dysfunction
COVID‑19,
improve
immune
cell
function
provide
However,
potential
remains
underexplored
funding
limitations
thus
further
investigations
required.
Язык: Английский
The parallel lives of pandemics: COVID‑19 and obesity
Experimental and Therapeutic Medicine,
Год журнала:
2024,
Номер
27(5)
Опубликована: Март 6, 2024
The
present
article
discusses
the
interconnectedness
of
coronavirus
disease
2019
(COVID‑19)
and
obesity
as
global
health
crises.
similarities
between
two
conditions
are
highlighted;
these
include
shared
risk
factors
comorbidities,
impact
on
immune
system.
also
mentions
challenges
faced
in
combating
both
pandemics,
including
misinformation
prejudice
against
obesity.
It
development
therapeutic
medications
vaccines
for
COVID‑19
potential
injectable
incretin
analogues
weight
loss.
Socioeconomic
issues
addressed,
with
being
more
prevalent
lower
socioeconomic
groups
cost
treatments
a
barrier
those
need.
emphasizes
need
comprehensive
sustainable
solutions,
public
interventions,
education,
policy
changes
equitable
distribution
resources,
to
address
Язык: Английский
Impact of COVID-19 on liver transplant recipients: A nationwide cohort study evaluating hospitalization, transplant rejection, and inpatient mortality
World Journal of Transplantation,
Год журнала:
2024,
Номер
14(2)
Опубликована: Июнь 13, 2024
BACKGROUND
The
coronavirus
disease
2019
(COVID-19)
pandemic
has
posed
a
major
public
health
concern
worldwide.
Patients
with
comorbid
conditions
are
at
risk
of
adverse
outcomes
following
COVID-19.
Solid
organ
transplant
recipients
concurrent
immunosuppression
and
comorbidities
more
susceptible
to
severe
COVID-19
infection.
It
could
lead
higher
rates
inpatient
complications
mortality
in
this
patient
population.
However,
studies
on
liver
(LT)
have
yielded
inconsistent
findings.
AIM
To
evaluate
the
impact
hospital-related
among
LT
United
States.
METHODS
We
conducted
retrospective
cohort
study
using
2019–2020
National
Inpatient
Sample
database.
primary
hospitalizations
secondary
diagnosis
were
identified
International
Classification
Diseases,
Tenth
Revision
coding
system.
included
trends
before
during
pandemic.
Secondary
comparative
rejection
recipients.
RESULTS
A
total
15720
hospitalized
included.
Approximately
0.8%
patients
had
In
both
cohorts,
median
admission
age
was
57
years.
linear
for
did
not
differ
significantly
(P
=
0.84).
frequency
in-hospital
increased
from
1.7%
4.4%
between
January
December
2020.
Compared
pre-pandemic
period,
association
noted
pandemic,
an
odds
ratio
(OR)
1.69
[95%
confidence
interval
(CI):
1.55-1.84),
P
<
0.001].
rejections
0.2%
3.6%
than
[OR:
1.53
(95%CI:
1.26-1.85),
CONCLUSION
hospitalization
comparable
Язык: Английский
Outcomes of COVID-19 in 24 hospitalized liver transplant recipients: an observational study
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Сен. 20, 2024
Although
liver
transplant
(LT)
recipients
are
considered
a
population
at
risk
of
severe
features
coronavirus
disease
2019
(COVID-19),
data
in
this
regard
scarce
and
controversial.
In
study,
we
reported
the
outcome
24
cases
LT
who
were
hospitalized
due
to
COVID-19
investigated
role-playing
factors
severity
disease.
Язык: Английский
Outcomes of liver transplantation patients infected with COVID-19: pandemic hospital experience from Turkey
Journal of Health Sciences and Medicine,
Год журнала:
2023,
Номер
6(6), С. 1154 - 1157
Опубликована: Окт. 29, 2023
Aims:
There
are
conflicting
results
for
the
course
of
disease
and
mortality
rates
liver
transplantation
patients
infected
with
COVID-19.
In
this
study,
we
aimed
to
present
outcomes
our
transplant
who
were
hospitalized
followed
up
in
tertiary
hospital,
which
served
as
a
pandemic
hospital
Methods:
Patients
diagnosis
COVID-19
between
March
1,
2020
2022
Sancaktepe
Şehit
Prof.
Dr.
İlhan
Varank
Training
Research
Hospital
Feriha
Öz
Pandemic
included.
retrospective
observational
clinical
data
patients,
need
intensive
care
hospitalization,
recorded
by
computer
system.
The
relationships
analyzed
SPSS
v20.0.
Results:
25996
28
them
history
transplantation.
Ages
ranged
from
18
73,
median
age
52.
82.1%
male
17.9%
female.
Intensive
unit
hospitalization
rate
was
25%
14.3%.
according
groups
revealed
that
all
women
under
50
(p=0.008)
deceased
over
(p=0.044).
Conclusion:
Mortality
requirements
chronically
immunosuppressed
infection
similar
general
population.
Complete
immunosuppression
withdrawal
should
not
be
urged
Язык: Английский