International Immunopharmacology,
Год журнала:
2024,
Номер
140, С. 112886 - 112886
Опубликована: Авг. 10, 2024
High
mobility
group
box
proterin-1
(HMGB-1)
is
a
multifunctional
protein
that
can
be
released
by
various
programmed
cell
deaths
(PCDs),
such
as
necroptosis
and
ferroptosis.
PCDs
play
critical
role
in
the
pathogenesis
of
systemic
lupus
erythematosus
(SLE).
However,
HMGB-1
process
SLE
remains
unclear.
This
study
aims
to
demonstrate
potential
diagnosing
serum
We
found
levels
HMGB-1,
receptor-interacting
kinase
3
(RIPK3)
/mixed
lineage
domain-like
(MLKL)
related
with
necroptosis,
metabolites
associated
ferroptosis
were
significantly
upregulated
patients
compared
HC
individuals.
These
positively
correlated
disease
activity.
Additionally,
level
showed
strong
positive
RIPK3/MLKL
metabolites.
Moreover,
was
renal
involvement
high-antinuclear
antibodies
(ANA)
titer.
After
interferon
γ
(IFN-γ)
treatment
vitro,
markers
activated
HMGB1
both
HEK293
HK2
cells.
Clinically,
considered
significant
independent
risk
factor
binary
logistic
assay.
Notably,
exhibited
outstanding
diagnostic
ability
for
area
under
curve
(AUC)
receiver
operating
characteristic
(ROC)
analysis.
Taken
together,
our
indicates
promising
biomarker
diagnosis
monitoring
SLE.
Endothelial
injury
destroys
endothelial
barrier
integrity,
triggering
organ
dysfunction
and
ultimately
resulting
in
sepsis-related
death.
Considerable
attention
has
been
focused
on
identifying
effective
targets
for
inhibiting
damage
to
cells
treat
endotoxemia-induced
septic
shock.
Global
gasdermin
D
(Gsdmd)
deletion
reportedly
prevents
death
caused
by
endotoxemia.
However,
the
role
of
GSDMD
lethality
lipopolysaccharide-induced
(LPS-induced)
endotoxemia
underlying
regulatory
mechanisms
are
unknown.
Here,
we
show
that
LPS
increases
level
aortas
lung
microvessels.
We
demonstrated
Gsdmd
deficiency,
but
not
myeloid
cell
deletion,
protects
against
mice
with
or
sepsis.
In
vivo
experiments
suggested
hepatocyte
mediated
release
high-mobility
group
box
1,
which
subsequently
binds
receptor
advanced
glycation
end
products
cause
systemic
vascular
injury,
acute
shock
driven
Additionally,
activation
via
a
polypeptide
inhibitor
alleviated
improved
survival
mouse
model
These
data
suggest
is
viable
pharmaceutical
target
treating
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
151, С. 113191 - 113191
Опубликована: Май 25, 2022
Pulmonary
hypertension
(PH)
is
a
chronic
and
fatal
disease,
for
which
new
therapeutic
drugs
approaches
are
needed
urgently.
Baicalein
baicalin,
the
active
compounds
of
traditional
Chinese
medicine,
Scutellaria
baicalensis
Georgi,
exhibit
wide
range
pharmacological
activities.
Numerous
studies
involving
in
vitro
vivo
models
PH
have
revealed
that
treatment
with
baicalin
baicalein
may
be
effective.
This
review
summarizes
potential
mechanisms
driving
beneficial
effects
on
PH,
including
anti-inflammatory
response,
inhibition
pulmonary
smooth
muscle
cell
proliferation
endothelial-to-mesenchymal
transformation,
stabilization
extracellular
matrix,
mitigation
oxidative
stress.
The
pharmacokinetics
these
also
been
reviewed.
warrants
their
continued
study
as
natural
treatments
PH.
Genes & Diseases,
Год журнала:
2023,
Номер
11(2), С. 874 - 889
Опубликована: Июль 19, 2023
Glioblastoma
(GBM)
is
the
most
common
intrinsic
and
aggressive
primary
brain
tumor
in
adults,
with
a
median
survival
of
approximately
15
months.
GBM
heterogeneity
considered
responsible
for
treatment
resistance
unfavorable
prognosis.
Proneural-mesenchymal
transition
(PMT)
represents
malignant
progression
recurrence,
which
might
be
breakthrough
to
understand
overcome
resistance.
PMT
complicated
process
influenced
by
crosstalk
between
microenvironment,
depending
on
intricate
ligand-receptor
interactions.
In
this
review,
we
summarize
autocrine
paracrine
pathways
microenvironment
related
interactions
inducing
PMT.
We
also
discuss
current
therapies
targeting
PMT-related
pathways.
Together,
review
offers
comprehensive
understanding
failure
GBM-targeted
therapy
ideas
future
tendencies
treatment.
