HDAC6 inhibition through WT161 synergizes with temozolomide, induces apoptosis, reduces cell motility, and decreases β-catenin levels in glioblastoma cells
Investigational New Drugs,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 15, 2025
Язык: Английский
Inhibitory Effects of Paclitaxel-Loaded Iron Oxide Nanoparticles on Non-Small Cell Lung Cancer by Enhancing Autophagy-Dependent Ferroptosis and Apoptosis Pathways
Ruijuan Deng,
Guanghong Liang,
Wenqing Chen
и другие.
Cancer Management and Research,
Год журнала:
2025,
Номер
Volume 17, С. 541 - 555
Опубликована: Март 1, 2025
Background:
Iron
oxide
nanoparticles
coated
with
paclitaxel
(IONP@PTX)
are
frequently
applied
to
various
tumor
types.
However,
inhibitory
effect
and
possible
mechanism
of
IONP@
PTX
on
non-small-cell
lung
cancer
(NSCLC)
remain
unclear.
Objective:
This
work
aimed
assess
effects
potential
mechanisms
IONP@PTX
A549
cells
further
explore
the
nanomedicine
delivery
systems
for
applications
in
therapies.
Methods:
Morphology
features
qualities
were
directly
assessed.
After
treatment
either
or
IONP@PTX,
cell
viability
apoptosis
separately
detected
by
CCK‑8
assay
flow
cytometry.
In
addition,
intracellular
iron
ion,
lipid
peroxidation
(LPD)
reactive
oxygen
species
(ROS)
identified
using
an
colorimetric
kit,
DCFH-DA
C11-BODIPY
fluorescent
probe,
respectively.
Moreover,
expression
levels
autophagy-,
ferroptosis-,
apoptosis-related
proteins
measured
Western
blot.
Results:
The
synthesized
had
a
core
particle
size
about
10
nm
hydrated
31.01±
2.47
nm.
comparison
PTX,
stronger
anti-tumor
cells,
considerably
higher
ROS,
LPD,
total
ion
concentration
(
P
<
0.05).
Likewise,
markedly
reduced
GPX4,
FTH,
SLC7A11
whereas
obviously
increased
LC3II/I
ACSL4
Furthermore,
both
could
be
evidently
reversed
additional
3-methyladenine
(3-MA)
ferrostatin-1.
Interestingly,
rates
together
level
pro-apoptotic
protein
Cleaved
caspase-3,
significantly
group
than
those
control
groups
Conclusion:
inhibits
proliferation
human
enhancing
autophagy-dependent
ferroptosis
pathways.
Keywords:
paclitaxel,
ferroptosis,
autophagy,
Язык: Английский
Radiosensitizing effects of heparinized magnetic iron oxide nanoparticles in colon cancer
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116668 - 116668
Опубликована: Май 2, 2024
The
combination
of
radiation
treatment
and
chemotherapy
is
currently
the
standard
for
management
cancer
patients.
However,
safe
doses
do
not
often
provide
effective
therapy,
then
pre-treated
patients
are
forced
to
repeat
with
already
increased
tumor
resistance
drugs
irradiation.
One
solutions
we
suggest
improve
primary
course
via
enhancing
radiosensitivity
tumors
by
magnetic-guided
iron
oxide
nanoparticles
(magnetite).
We
obtained
spherical
heparinized
(hIONPs,
∼20
nm),
characterized
it
TEM,
Infrared
spectroscopy
DLS.
Then
hIONPs
cytotoxicity
was
assessed
colon
cells
(XTT
assay)
cellular
uptake
analyzed
X-ray
fluorescence.
Combination
ionizing
(IR)
in
vitro
caused
an
increase
G2/M
arrest
cell
cycle,
mitotic
errors
decrease
survival
(compared
samples
exposed
IR
separately).
promising
results
were
shown
CT26-grafted
BALB/C
mice:
intravenously
administrated
showed
20,8%
T/C
ratio
(related
non-treated
mice),
while
single
had
no
significant
growth
(72,4%).
Non-guided
magnets
57,9%
T/C.
This
indicates
that
ultra-small
size
biocompatible
molecule
key
successful
nano-drug
design,
each
case,
delivery
technologies
need
be
improved
when
transferred
vivo
model.
Язык: Английский
Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 9, 2024
Lung
cancer
has
high
metastasis
and
drug
resistance.
The
prognosis
of
lung
patients
is
poor
the
patients’
survival
chances
are
easily
neglected.
Ferroptosis
a
programmed
cell
death
proposed
in
2012,
which
differs
from
apoptosis,
necrosis
autophagy.
novel
type
regulated
driven
by
iron-dependent
lipid
peroxidation
subsequent
plasma
membrane
ruptures.
It
broad
prospects
field
tumor
disease
treatment.
At
present,
multiple
studies
have
shown
that
biological
compounds
can
induce
ferroptosis
cells,
exhibits
significant
anti-cancer
effects,
they
advantages
safety,
minimal
side
less
possibility
to
In
this
review,
we
summarize
used
for
treatment
focusing
on
its
mechanism.
addition,
systematically
review
current
research
status
combining
nanotechnology
with
treatment,
shed
new
light
targeting
pathways
applying
compounds-based
therapies.
Язык: Английский
Nano-inducer of ferroptosis for targeted chemotherapy of human triple negative breast carcinoma
Biomaterials Advances,
Год журнала:
2024,
Номер
161, С. 213868 - 213868
Опубликована: Апрель 21, 2024
Язык: Английский
Ferroptosis-inducing nanocomposite hydrogels: A multimodal platform for enhanced cancer therapeutics
Chemical Engineering Journal,
Год журнала:
2024,
Номер
500, С. 157451 - 157451
Опубликована: Ноя. 1, 2024
Язык: Английский
Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy
Journal of Immunotoxicology,
Год журнала:
2024,
Номер
21(1)
Опубликована: Ноя. 1, 2024
Nanoparticles
are
commonly
used
in
diagnostics
and
therapy.
They
also
increasingly
being
implemented
cancer
immunotherapy
because
of
their
ability
to
deliver
drugs
modulate
the
immune
system.
However,
effect
nanoparticles
on
cells
involved
anti-tumor
response
is
not
well
understood.
The
study
reported
here
showed
that
nickel-doped
maghemite
(FN
NP)
differentially
cytotoxic
cultured
mouse
human
cell
lines,
causing
death
without
negatively
impacting
subsequent
anticancer
response.
It
found
FN
NP
induced
colorectal
line
CT26
prostate
PC-3,
but
LNCaP.
did
affect
phenotype
responsivity
isolated
peritoneal
macrophages,
or
ex
vivo-generated
bone
marrow-derived,
monocyte-derived
dendritic
cells.
Additionally,
prevent
from
stimulating
lymphocytes
enriching
cultures
with
cell-reactive
T-cells.
In
conclusion,
this
shows
could
be
a
valuable
platform
for
targeting
immunosuppressive
effects
Язык: Английский