Functional
fermentation
strains
were
isolated
and
screened
from
traditional
fairy
beans
in
northern
Anhui.
Through
technical
identification,
Bacillus
subtilis
SXD06
was
determined
to
be
the
superior
strain,
while
Wickerhamomyces
anomalus
YE006
identified
as
optimal
aroma-producing
yeast.
Utilizing
single-factor
experiments
response
surface
optimization,
a
Central
Composite
Design
blending
model
established.
The
conditions
be:
an
inoculation
amount
of
1.1%
for
SXD06,
4.2%
YE006,
temperature
34
°C,
Fermentation
lasted
84.2
h.
SDS-PAGE
electrophoresis
comparison
between
control
sample
groups
indicated
effective
fermentation,
with
most
converting
amino
acids.
Optimal
5.5%
salt,
0.26%
star
anise
powder,
0.25%
cinnamon,
1.5%
pepper,
4.5%
edible
alcohol,
0.28%
fragrant
leaves.
sensory
evaluation
soybean
products
produced
under
specified
yielded
highest
scores.
This
study
offers
robust
support
development
low-ammonia,
high-quality
bean
that
align
consumer
preferences.
Catalysts,
Год журнала:
2025,
Номер
15(5), С. 454 - 454
Опубликована: Май 7, 2025
Enzymes
of
the
cytochrome
P450
monooxygenase
family
4
(CYP4)
in
mammals
are
generally
involved
either
endobiotic
metabolism
(e.g.,
acting
on
fatty
acids
or
eicosanoids),
modification
xenobiotics
including
therapeutic
drugs.
CYP4B1
is
special,
as
it
an
enigmatic
enzyme
at
interface
between
xenobiotic
and
metabolism.
However,
a
systematic
analysis
CYP4B1’s
substrate
scope
has
not
yet
been
reported.
Herein,
three-step
approach
to
identify
novel
substrates
for
three
orthologs
(namely
from
rabbits,
green
monkeys,
mouse
lemurs)
described.
First,
screening
library
containing
502
natural
products
revealed
potential
groups
CYP4B1.
Second,
based
these
results,
was
defined
consisting
63
compounds
representing
10
compound
groups.
Third,
vitro
conversion
by
identification
were
conducted,
supported
silico
docking,
allowing
prediction
binding
probabilities
oxidation
sites.
We
report
five
new
(acyclic,
monocyclic
bicyclic
terpenoids,
stilbenoids,
vanilloids),
twenty-eight
(inter
alia
capsaicin,
gingerol,
genistein,
stilbene,
myristicin,
thioanisole),
two
reaction
types
(S-oxidation,
O-demethylation).
Consequently,
far
more
promiscuous
than
previously
thought.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 7, 2025
Obesity
is
a
major
global
health
challenge,
contributing
to
metabolic
disorders
such
as
type
2
diabetes,
cardiovascular
diseases,
and
hypertension.
The
increasing
prevalence
of
obesity,
driven
by
sedentary
lifestyles,
poor
dietary
habits,
genetic
predisposition,
underscores
the
urgent
need
for
effective
therapeutic
strategies.
Conventional
pharmacological
treatments,
including
appetite
suppressants
modulators,
often
fail
provide
sustainable
weight
loss
due
side
effects,
adherence,
limited
long-term
efficacy.
As
result,
natural
bioactive
compounds
have
gained
attention
their
anti-obesity
potential.
However,
clinical
application
hindered
bioavailability,
rapid
metabolism,
inefficient
delivery.
Lipid-based
nano-carriers,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers,
offer
promising
solution
enhancing
solubility,
stability,
targeted
delivery
these
compounds.
These
advanced
systems
improve
retention,
enable
controlled
release,
enhance
action
on
adipose
tissue
pathways.
Additionally,
functionalized
stimulus-responsive
nanocarriers
present
innovative
approaches
precision
obesity
treatment.
Despite
advancements,
challenges
remain
in
large-scale
production,
regulatory
approval,
safety.
Overcoming
barriers
critical
ensuring
successful
translation
nano-formulated
therapies.
This
review
explores
potential
lipid-based
nano-carriers
optimizing
efficacy
highlights
role
advancing
next-generation
management
Journal of Natural Remedies,
Год журнала:
2025,
Номер
unknown, С. 943 - 949
Опубликована: Апрель 24, 2025
Background:
Capsaicin
is
one
of
the
most
widely
utilized
global
bioactive
dietary
ingredients
exhibiting
multiple
health
benefits
to
both
humans
and
animals.
However,
any
earlier
report
lacking
evidence
related
hepatoprotective
activity
capsaicin
on
zebra
fish
model.
Aim:
The
study
demonstrates
antioxidant
(in
vitro)
vivo)
capsaicin.
Methods:
was
performed
using
2,2-Diphenyl-1-Picrylhydrazyl
(DPPH)
radical
scavenging
method
were
alcohol
induced
zebrafish
liver
damage,
respectively.
Results:
In
outcome
we
have
found
that
able
demonstrate
significant
action
as
from
experiments.
Conclusion:
conclusion
current
validated
role
in
improving
toxicity
through
mechanism
can
be
useful
develop
many
value
added
products
near
future.
Major
Findings:
(8-methyl-N-vanillyl-6-nonenamide,
Chili
peppers)
exhibits
a
scientific
resulted
DPPH
damage
vivo).
Current
research
for
designing
future
remedies
management
toxicity.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(5)
Опубликована: Май 1, 2025
Human
beings
are
naturally
drawn
to
food
flavors
and
pleasant
aromas,
which
not
only
guide
choices
but
also
contribute
health
by
promoting
the
intake
of
nutritious
foods,
aiding
digestion,
enhancing
emotional
well-being.
This
review
explores
complex
relationship
between
flavor,
nutrition,
health,
highlighting
that
flavor
perception
can
be
affected
genetic
susceptibility,
age,
culture,
gender,
early
life
experiences.
They
influence
physiological
responses
through
brain
mechanisms,
directly
affecting
selection
outcomes.
The
use
natural
enhances
taste
encourages
healthier
choices.
In
contrast,
widespread
artificial
flavors,
while
often
boosting
sales,
leads
overconsumption
less
products,
thereby
increasing
potential
risks.
There
is
a
growing
trend
among
health-conscious
consumers
shows
preference
for
organic
despite
challenges
such
as
low
bioavailability
limited
evidence
their
effectiveness.
However,
advancements
in
processing
technologies
microencapsulation
novel
extraction
methods
offer
promising
tools
improve
stability
sensory
acceptance,
making
products
more
appealing
widely
acceptable.
addition,
strategic
manner
most
relevant
reformulation,
dietary
interventions,
nutrition
education,
where
it
make
sustainable
Subsequent
research
needs
focus
on
human
trials
optimize
delivery
techniques
dosages,
along
with
role
traits
environmental
influences
customized
perception.
Governments
across
world
need
impose
stricter
regulations
synthetic
additives
ensure
safety
safeguard
consumer
health.
Metabolites,
Год журнала:
2025,
Номер
15(6), С. 372 - 372
Опубликована: Июнь 5, 2025
Background/Objectives:
Capsaicin
is
the
principal
pungent
compound
in
chili
peppers
and
increasingly
recognized
as
a
multifunctional
phytochemical
with
systemic
effects
beyond
its
sensory
properties.
It
has
been
linked
to
metabolic
regulation,
neuroprotection,
inflammation
control,
cancer
modulation.
This
review
aims
provide
an
integrative
synthesis
of
capsaicin’s
metabolism,
interaction
gut
microbiome,
physiological
implications
across
organ
systems.
Methods:
We
conducted
critical
literature
recent
vivo
vitro
studies
exploring
fate,
biotransformation
by
host
enzymes
microbes,
tissue
distribution,
molecular
pathways.
The
was
analyzed
thematically
cover
gastrointestinal
absorption,
hepatic
microbiota
interactions,
cellular
responses.
Results:
undergoes
extensive
producing
hydroxylated
dehydrogenated
metabolites
that
differ
transient
receptor
potential
vanilloid
type
1
(TRPV1)
affinity
tissue-specific
bioactivity.
crosses
blood–brain
barrier,
alters
neurotransmitter
levels,
accumulates
brain
regions
involved
cognition.
In
addition
effects,
capsaicin
appears
undergo
microbial
transformation
influences
composition,
favoring
short-chain
fatty
acid
producers
suppressing
pro-inflammatory
taxa.
These
changes
contribute
anti-obesity,
anti-inflammatory,
potentially
anticancer
effects.
Dose-dependent
adverse
outcomes,
such
epithelial
damage
or
tumor
promotion,
have
also
observed.
Conclusions:
represents
diet-derived
bioactive
molecule
whose
impact
shaped
dynamic
interactions
between
metabolism
microbiota.
Clarifying
pathways
context-specific
essential
for
safe
effective
use
neurological
health
strategies.
Acta Biochimica et Biophysica Sinica,
Год журнала:
2024,
Номер
56(7), С. 957 - 962
Опубликована: Май 11, 2024
Transient
receptor
potential
channel
subfamily
vanilloid
1
(TRPV1)
is
a
member
of
the
transient
family
nonselective
cationic
transmembrane
proteins
that
are
involved
in
regulation
calcium
homeostasis.
It
expressed
various
tumor
types
and
has
been
implicated
cancer
growth,
metastasis,
apoptosis,
cancer-related
pain.
TRPV1
highly
triple-negative
breast
(TNBC),
both
its
agonists
antagonists
may
exert
anti-cancer
effects.
In
this
review,
we
provide
an
overview
effect
on
TNBC
development
influence
immunotherapy
attempt
to
facilitate
future
treatment
strategies.
Nutrients,
Год журнала:
2024,
Номер
16(18), С. 3167 - 3167
Опубликована: Сен. 19, 2024
Capsaicin,
a
bioactive
compound
found
in
peppers,
is
recognized
for
its
anti-inflammatory,
antioxidant,
and
anti-lipidemic
properties.
This
study
aimed
to
evaluate
the
effects
of
capsaicin
on
atherosclerosis
progression.
