AMB Express,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Dec. 26, 2024
Functional
fermentation
strains
were
isolated
and
screened
from
traditional
fairy
beans
in
northern
Anhui.
Through
technical
identification,
Bacillus
subtilis
SXD06
was
determined
to
be
the
superior
strain,
while
Wickerhamomyces
anomalus
YE006
identified
as
optimal
aroma-producing
yeast.
Utilizing
single-factor
experiments
response
surface
optimization,
a
Central
Composite
Design
blending
model
established.
The
conditions
be:
an
inoculation
amount
of
1.1%
for
SXD06,
4.2%
YE006,
temperature
34
°C,
Fermentation
lasted
84.2
h.
SDS-PAGE
electrophoresis
comparison
between
control
sample
groups
indicated
effective
fermentation,
with
most
converting
amino
acids.
Optimal
5.5%
salt,
0.26%
star
anise
powder,
0.25%
cinnamon,
1.5%
pepper,
4.5%
edible
alcohol,
0.28%
fragrant
leaves.
sensory
evaluation
soybean
products
produced
under
specified
yielded
highest
scores.
This
study
offers
robust
support
development
low-ammonia,
high-quality
bean
that
align
consumer
preferences.
Catalysts,
Journal Year:
2025,
Volume and Issue:
15(5), P. 454 - 454
Published: May 7, 2025
Enzymes
of
the
cytochrome
P450
monooxygenase
family
4
(CYP4)
in
mammals
are
generally
involved
either
endobiotic
metabolism
(e.g.,
acting
on
fatty
acids
or
eicosanoids),
modification
xenobiotics
including
therapeutic
drugs.
CYP4B1
is
special,
as
it
an
enigmatic
enzyme
at
interface
between
xenobiotic
and
metabolism.
However,
a
systematic
analysis
CYP4B1’s
substrate
scope
has
not
yet
been
reported.
Herein,
three-step
approach
to
identify
novel
substrates
for
three
orthologs
(namely
from
rabbits,
green
monkeys,
mouse
lemurs)
described.
First,
screening
library
containing
502
natural
products
revealed
potential
groups
CYP4B1.
Second,
based
these
results,
was
defined
consisting
63
compounds
representing
10
compound
groups.
Third,
vitro
conversion
by
identification
were
conducted,
supported
silico
docking,
allowing
prediction
binding
probabilities
oxidation
sites.
We
report
five
new
(acyclic,
monocyclic
bicyclic
terpenoids,
stilbenoids,
vanilloids),
twenty-eight
(inter
alia
capsaicin,
gingerol,
genistein,
stilbene,
myristicin,
thioanisole),
two
reaction
types
(S-oxidation,
O-demethylation).
Consequently,
far
more
promiscuous
than
previously
thought.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: May 7, 2025
Obesity
is
a
major
global
health
challenge,
contributing
to
metabolic
disorders
such
as
type
2
diabetes,
cardiovascular
diseases,
and
hypertension.
The
increasing
prevalence
of
obesity,
driven
by
sedentary
lifestyles,
poor
dietary
habits,
genetic
predisposition,
underscores
the
urgent
need
for
effective
therapeutic
strategies.
Conventional
pharmacological
treatments,
including
appetite
suppressants
modulators,
often
fail
provide
sustainable
weight
loss
due
side
effects,
adherence,
limited
long-term
efficacy.
As
result,
natural
bioactive
compounds
have
gained
attention
their
anti-obesity
potential.
However,
clinical
application
hindered
bioavailability,
rapid
metabolism,
inefficient
delivery.
Lipid-based
nano-carriers,
liposomes,
solid
lipid
nanoparticles,
nanostructured
carriers,
offer
promising
solution
enhancing
solubility,
stability,
targeted
delivery
these
compounds.
These
advanced
systems
improve
retention,
enable
controlled
release,
enhance
action
on
adipose
tissue
pathways.
Additionally,
functionalized
stimulus-responsive
nanocarriers
present
innovative
approaches
precision
obesity
treatment.
Despite
advancements,
challenges
remain
in
large-scale
production,
regulatory
approval,
safety.
Overcoming
barriers
critical
ensuring
successful
translation
nano-formulated
therapies.
This
review
explores
potential
lipid-based
nano-carriers
optimizing
efficacy
highlights
role
advancing
next-generation
management
Journal of Natural Remedies,
Journal Year:
2025,
Volume and Issue:
unknown, P. 943 - 949
Published: April 24, 2025
Background:
Capsaicin
is
one
of
the
most
widely
utilized
global
bioactive
dietary
ingredients
exhibiting
multiple
health
benefits
to
both
humans
and
animals.
However,
any
earlier
report
lacking
evidence
related
hepatoprotective
activity
capsaicin
on
zebra
fish
model.
Aim:
The
study
demonstrates
antioxidant
(in
vitro)
vivo)
capsaicin.
Methods:
was
performed
using
2,2-Diphenyl-1-Picrylhydrazyl
(DPPH)
radical
scavenging
method
were
alcohol
induced
zebrafish
liver
damage,
respectively.
Results:
In
outcome
we
have
found
that
able
demonstrate
significant
action
as
from
experiments.
Conclusion:
conclusion
current
validated
role
in
improving
toxicity
through
mechanism
can
be
useful
develop
many
value
added
products
near
future.
Major
Findings:
(8-methyl-N-vanillyl-6-nonenamide,
Chili
peppers)
exhibits
a
scientific
resulted
DPPH
damage
vivo).
Current
research
for
designing
future
remedies
management
toxicity.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8979 - 8979
Published: Aug. 18, 2024
Chronic
low-grade
inflammation
(CLGI)
is
associated
with
obesity
and
one
of
its
pathogenetic
mechanisms.
Lipopolysaccharide
(LPS),
a
component
Gram-negative
bacterial
cell
walls,
the
principal
cause
CLGI.
Studies
have
found
that
capsaicin
significantly
reduces
relative
abundance
LPS-producing
bacteria.
In
present
study,
Acta Biochimica et Biophysica Sinica,
Journal Year:
2024,
Volume and Issue:
56(7), P. 957 - 962
Published: May 11, 2024
Transient
receptor
potential
channel
subfamily
vanilloid
1
(TRPV1)
is
a
member
of
the
transient
family
nonselective
cationic
transmembrane
proteins
that
are
involved
in
regulation
calcium
homeostasis.
It
expressed
various
tumor
types
and
has
been
implicated
cancer
growth,
metastasis,
apoptosis,
cancer-related
pain.
TRPV1
highly
triple-negative
breast
(TNBC),
both
its
agonists
antagonists
may
exert
anti-cancer
effects.
In
this
review,
we
provide
an
overview
effect
on
TNBC
development
influence
immunotherapy
attempt
to
facilitate
future
treatment
strategies.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(18), P. 3167 - 3167
Published: Sept. 19, 2024
Capsaicin,
a
bioactive
compound
found
in
peppers,
is
recognized
for
its
anti-inflammatory,
antioxidant,
and
anti-lipidemic
properties.
This
study
aimed
to
evaluate
the
effects
of
capsaicin
on
atherosclerosis
progression.
Foods,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1810 - 1810
Published: June 8, 2024
“Morzeddhu”
in
the
local
dialect
of
Catanzaro
(“Morzello”
Italian)
is
an
official
typical
dish
capital
Calabria
region.
It
a
peasant
dish,
almost
unknown
at
international
level,
that
labels,
extraordinary
way,
culinary
identity
Catanzaro,
city
founded
around
X
century.
After
America’s
discovery,
its
preparation
was
optimized
and
definitively
fixed.
Its
recipe
strictly
based
on
cow’s
“fifth
quarter”
combined
with
spicy
Mediterranean
vegetables.
Remarkably,
no
pork
meat
used,
when
all
traditional
ingredients
are
included
complex
quite
long
this
special
it
can
deserve
title
“Illustrissimo”.
This
review
provides
scientific
description
Illustrissimo,
emphasizing
unique
properties
connection
to
circular
economy,
food
security,
diet.
We
also
highlight
quality
compared
other
alternatives
through
analysis
their
nutritional
facts
bioactive
compounds.
Nutritionally,
offal
fifth
quarter
components
rich
source
high-quality
protein,
lower
levels
total
fat
saturated
fatty
acids
cuts.
In
essence,
offers
great
example
yet
affordable
meal,
aligning
perfectly
Current Opinion in Supportive and Palliative Care,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Purpose
of
review
Advances
in
oncological
therapies
have
resulted
an
increase
the
number
patients
living
with
and
beyond
cancer.
The
personal
societal
impact
chronic
pain
survivor
population
represents
area
significant
unmet
need.
Capsaicin
(a
TRPV1
agonist)
may
provide
analgesia
limited
systemic
side
effects.
This
looks
to
summarise
most
recent
evidence
regarding
use
capsaicin
management
cancer
pain.
Recent
findings
Various
international
guidelines
recently
endorsed
high
concentration
patches
treatment
painful
chemotherapy
induced
peripheral
neuropathy.
Numerous
studies
support
neuropathic
promising
data
is
predominantly
yielded
from
secondary
herpes
zoster
diabetic
neuropathy,
expanding
but
small
base
for
its
utility
other
pains.
Emerging
suggests
that
treatments
are
better
tolerated
more
rapidly
when
compared
treatments.
Summary
Whilst
randomised
controlled
trial
lacking,
large
cohort
studies,
guidelines,
a
wide
variety
