Proteoglycans of basement membranes: Crucial controllers of angiogenesis, neurogenesis, and autophagy
Proteoglycan Research,
Год журнала:
2024,
Номер
2(3)
Опубликована: Июнь 29, 2024
Anti-angiogenic
therapy
is
an
established
method
for
the
treatment
of
several
cancers
and
vascular-related
diseases.
Most
agents
employed
target
vascular
endothelial
growth
factor
A,
major
cytokine
stimulating
angiogenesis.
However,
efficacy
these
treatments
limited
by
onset
drug
resistance.
Therefore,
it
fundamental
importance
to
better
understand
mechanisms
that
regulate
angiogenesis
microenvironmental
cues
play
significant
role
influence
patient
outcome.
In
this
context,
here
we
review
three
basement
membrane
heparan
sulfate
proteoglycans
(HSPGs),
namely
perlecan,
agrin
collagen
XVIII.
These
HSPGs
are
abundantly
expressed
in
vasculature
and,
due
their
complex
molecular
architecture,
they
interact
with
multiple
cell
receptors,
deeply
affecting
function.
Under
normal
conditions,
exert
pro-angiogenic
functions.
pathological
conditions
such
as
cancer
inflammation,
extracellular
matrix
remodeling
leads
degradation
large
precursor
molecules
liberation
bioactive
processed
fragments
displaying
potent
angiostatic
activity.
unexpected
functions
have
been
demonstrated
C-terminal
perlecan
XVIII,
endorepellin
endostatin.
can
also
induce
autophagy
cells
which
contributes
angiostasis.
Overall,
affect
counterbalancing
signals
during
tumor
progression,
represent
possible
means
develop
new
prognostic
biomarkers
novel
therapeutic
approaches
solid
tumors.
Язык: Английский
Biomechanical properties of laminins and their impact on cancer progression
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
1879(6), С. 189181 - 189181
Опубликована: Сен. 18, 2024
Язык: Английский
Analysing glycolysis-related genes reveals the prognostic and diagnostic relevance of IER3 and AGRN in colorectal cancer
Genes & Genomics,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Язык: Английский
Circulatory Agrin Serves as a Prognostic Indicator for Hepatocellular Carcinoma
Cancers,
Год журнала:
2024,
Номер
16(15), С. 2719 - 2719
Опубликована: Июль 31, 2024
Hepatocellular
carcinoma
(HCC),
the
predominant
form
of
liver
cancer,
is
associated
with
high
mortality
rates
both
in
United
States
and
globally.
Despite
current
advances
immunotherapy
regimens,
there
a
scarcity
biomarkers
to
guide
therapy
selection.
Alpha-fetoprotein
(AFP)
glypican-3
have
been
proposed
as
for
HCC,
but
they
do
not
provide
any
prognostic
benefit
modeling
disease
progression.
Agrin,
secreted
proteoglycan,
frequently
overexpressed
HCC
plays
prominent
role(s)
tumor
microenvironment
(TME)
promote
hepatocarcinogenesis.
Here
we
employed
pilot
single-center
retrospective
investigation
assess
value
agrin
HCC.
Our
evidence
suggests
that
elevated
serum
levels
are
poor
prognosis
performance
among
patients.
Multivariate
Cox
regression
models
indicate
serves
better
indicator
compared
AFP
significantly
correlated
other
(e.g.,
IL6).
Cumulatively,
this
work
demonstrates
promising
clinical
detection
Язык: Английский
Identification and validation of basement membrane‐associated gene AGRN as prognostic and immune‐associated biomarkers in colorectal cancer patients
Journal of Cellular and Molecular Medicine,
Год журнала:
2024,
Номер
28(16)
Опубликована: Авг. 1, 2024
Abstract
Colorectal
cancer
(COCA)
has
a
poor
prognosis,
with
growing
evidence
implicating
basement
membranes
(BMs)
in
progression.
Our
goal
was
to
investigate
the
role
and
predictive
significance
of
BMs
COCA
patients.
We
obtained
BMs‐related
genes
from
cutting‐edge
research
used
TCGA
GTEx
databases
for
mRNA
expression
patient
information.
Cox
regression
LASSO
were
prognostic
gene
selection
risk
model
construction.
compared
prognosis
using
Kaplan–Meier
analysis
examined
drug
sensitivity
differences.
The
CMAP
dataset
identified
potential
small
molecule
drugs.
In
vitro
tests
involved
suppressing
crucial
observe
its
impact
on
tumour
metastasis.
developed
12
BMs‐based
approach,
finding
it
be
an
independent
factor.
Functional
showed
concentrated
cancer‐associated
pathways,
correlating
immune
cell
infiltration
checkpoint
activation.
High‐risk
individuals
exhibited
increased
sensitivity.
AGRN
levels
linked
decreased
progression‐free
survival
(
p
<
0.001).
knockdown
suppressed
growth
study
offers
new
perspectives
COCA,
concluding
that
is
dependable
biomarker
prognosis.
Язык: Английский