Identification and validation of basement membrane‐associated gene AGRN as prognostic and immune‐associated biomarkers in colorectal cancer patients DOI Creative Commons
Jianrong Li,

Daofeng You,

Linjie Hu

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(16)

Published: Aug. 1, 2024

Abstract Colorectal cancer (COCA) has a poor prognosis, with growing evidence implicating basement membranes (BMs) in progression. Our goal was to investigate the role and predictive significance of BMs COCA patients. We obtained BMs‐related genes from cutting‐edge research used TCGA GTEx databases for mRNA expression patient information. Cox regression LASSO were prognostic gene selection risk model construction. compared prognosis using Kaplan–Meier analysis examined drug sensitivity differences. The CMAP dataset identified potential small molecule drugs. In vitro tests involved suppressing crucial observe its impact on tumour metastasis. developed 12 BMs‐based approach, finding it be an independent factor. Functional showed concentrated cancer‐associated pathways, correlating immune cell infiltration checkpoint activation. High‐risk individuals exhibited increased sensitivity. AGRN levels linked decreased progression‐free survival ( p < 0.001). knockdown suppressed growth study offers new perspectives COCA, concluding that is dependable biomarker prognosis.

Language: Английский

Proteoglycans of basement membranes: Crucial controllers of angiogenesis, neurogenesis, and autophagy DOI Creative Commons
Maurizio Mongiat, Gabriel J. Pascal, Evelina Poletto

et al.

Proteoglycan Research, Journal Year: 2024, Volume and Issue: 2(3)

Published: June 29, 2024

Anti-angiogenic therapy is an established method for the treatment of several cancers and vascular-related diseases. Most agents employed target vascular endothelial growth factor A, major cytokine stimulating angiogenesis. However, efficacy these treatments limited by onset drug resistance. Therefore, it fundamental importance to better understand mechanisms that regulate angiogenesis microenvironmental cues play significant role influence patient outcome. In this context, here we review three basement membrane heparan sulfate proteoglycans (HSPGs), namely perlecan, agrin collagen XVIII. These HSPGs are abundantly expressed in vasculature and, due their complex molecular architecture, they interact with multiple cell receptors, deeply affecting function. Under normal conditions, exert pro-angiogenic functions. pathological conditions such as cancer inflammation, extracellular matrix remodeling leads degradation large precursor molecules liberation bioactive processed fragments displaying potent angiostatic activity. unexpected functions have been demonstrated C-terminal perlecan XVIII, endorepellin endostatin. can also induce autophagy cells which contributes angiostasis. Overall, affect counterbalancing signals during tumor progression, represent possible means develop new prognostic biomarkers novel therapeutic approaches solid tumors.

Language: Английский

Citations

5
Biomechanical properties of laminins and their impact on cancer progression DOI Creative Commons

Elena Nonnast,

E. Mira, Santos Mañes

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189181 - 189181

Published: Sept. 18, 2024

Language: Английский

Citations

4
Analysing glycolysis-related genes reveals the prognostic and diagnostic relevance of IER3 and AGRN in colorectal cancer DOI

Samaneh Dalali,

Fatemeh Kaviani,

Mohammad Mahdevar

et al.

Genes & Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Language: Английский

Citations

0
Circulatory Agrin Serves as a Prognostic Indicator for Hepatocellular Carcinoma DOI Open Access
Ankita Kapoor,

Reza Bayat Mokhtari,

Sahithi Sonti

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(15), P. 2719 - 2719

Published: July 31, 2024

Hepatocellular carcinoma (HCC), the predominant form of liver cancer, is associated with high mortality rates both in United States and globally. Despite current advances immunotherapy regimens, there a scarcity biomarkers to guide therapy selection. Alpha-fetoprotein (AFP) glypican-3 have been proposed as for HCC, but they do not provide any prognostic benefit modeling disease progression. Agrin, secreted proteoglycan, frequently overexpressed HCC plays prominent role(s) tumor microenvironment (TME) promote hepatocarcinogenesis. Here we employed pilot single-center retrospective investigation assess value agrin HCC. Our evidence suggests that elevated serum levels are poor prognosis performance among patients. Multivariate Cox regression models indicate serves better indicator compared AFP significantly correlated other (e.g., IL6). Cumulatively, this work demonstrates promising clinical detection

Language: Английский

Citations

1
Identification and validation of basement membrane‐associated gene AGRN as prognostic and immune‐associated biomarkers in colorectal cancer patients DOI Creative Commons
Jianrong Li,

Daofeng You,

Linjie Hu

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(16)

Published: Aug. 1, 2024

Abstract Colorectal cancer (COCA) has a poor prognosis, with growing evidence implicating basement membranes (BMs) in progression. Our goal was to investigate the role and predictive significance of BMs COCA patients. We obtained BMs‐related genes from cutting‐edge research used TCGA GTEx databases for mRNA expression patient information. Cox regression LASSO were prognostic gene selection risk model construction. compared prognosis using Kaplan–Meier analysis examined drug sensitivity differences. The CMAP dataset identified potential small molecule drugs. In vitro tests involved suppressing crucial observe its impact on tumour metastasis. developed 12 BMs‐based approach, finding it be an independent factor. Functional showed concentrated cancer‐associated pathways, correlating immune cell infiltration checkpoint activation. High‐risk individuals exhibited increased sensitivity. AGRN levels linked decreased progression‐free survival ( p < 0.001). knockdown suppressed growth study offers new perspectives COCA, concluding that is dependable biomarker prognosis.

Language: Английский

Citations

0