Harnessing marine microbiomes to develop a sustainable, all‐Atlantic bioeconomy DOI Creative Commons
Cristiane C. Thompson, Alice C. Ortmann, Henk Bolhuis

и другие.

mLife, Год журнала: 2024, Номер 3(2), С. 163 - 166

Опубликована: Май 27, 2024

Marine microbiomes are integral to the functioning of a healthy ocean and have potential be key contributors toward an all-Atlantic sustainable blue bioeconomy (Figure 1). New compounds may developed based on these microbiomes. The Atlantic Ocean is biodiversity hotspot. All-Atlantic Research Innovation Alliance (AAORIA) Declaration, signed in 2022 Washington, DC, promising mechanism move forward marine microbiome science, technology, innovation. However, innovation initiatives South require great attention. Here we highlight potential, challenges ahead, initiative. Successful examples around world discussed, suggestions put forward. Microbes including bacteria, archaea, protists, fungi represent majority biomass1. These microbes play central role nutrient cycling, fluxes energy, matter contributing primary production climate change mitigation2. Furthermore, long-term host–microbe co-evolution has allowed (in)vertebrates occupy diverse niches (e.g., deep sea, hydrothermal vents, coral reefs), facilitated by endosymbiotic which established stable partnerships with their hosts3. Tara global survey demonstrated that microbial diversity modulated water mass parameters, such as temperature nutrients4. More recently, Federation identified wealth novel pico-planktonic eukaryotic producers inhabiting oxygen minimum zones5. Simultaneously, databases artificial intelligence tools been for mining microbiomes6. Some developments being carried out collaboration industry expand knowledge While there much more discover about microbiomes, know they important players supporting food webs. We also functional remarkably high support bioeconomy. In this context, believe countries bordering (including representatives from Global North) create meaningful provide investment science needed address several United Nations Sustainable Development Goals. Almost 900 million people affected hunger (http://wfp.org; accessed April 10, 2024). Further pressure traditional agriculture aquaculture practices foreseen due human population increase, estimated approach up 10 billion 2050. responsible annual 88 metric tonnes fish, most produced inland (fresh) waters. Estimates suggest <40% fish derived systems (mariculture). Harvesting wild populations organisms cannot sustainably sufficient additional food. 35.4% stocks overfished 20197. Alternative approaches mariculture coastal urgently required. harness metabolic traits communities augment marine-derived resources8. Saline alternative (https://Simbaproject.eu; https://www.thesaltdoctors.com/). contribute sustainability reducing need freshwater making use less arable land. To promote saline agriculture, different applied high-tech microbiological screening plant growth-promoting genes salt-tolerant microbes. alter root habitats or modify physiology, increasing salt-impacted Microbiomes development low-carbon integrated multitrophic (IMTA). technologies focus developing recycle waste reduce antibiotic carbon emissions8. Biofloc technology (BFT) successfully shrimp aquaculture9. BFT consortia can serve source remediate rearing quality. offer drug discovery10. Antibiotic resistance, emergence new diseases, cancer rates pharmaceuticals public health challenges. Currently, >18,000 natural products environments (microorganisms macroorganisms)11. Of these, over 5000 patented11. 40,000 gene clusters, obtained 35,000 microorganisms macroorganisms, code highly bioactive molecules enzymes. On path, Blue Remediomics Initiative aims develop catalog datasets, medicines, cosmeceuticals, bioproducts (https://www.embl.org/news/science/blueremediomics-harnessing-marine-microbes-to-promote-a-circular-bioeconomy/). some remain poorly characterized. A recent initiative standard methods best (STI) (https://www.frontiersin.org/research-topics/15877/marine-microbiomes-towards-standard-methods-and-best-practices). priorities include measuring sampled regions sea South, quantifying interactions between microbiota, harnessing oceanic insights crucial efforts aimed at driving policy literacy4. series international agreements collaborative Atlantic12 consensus outcome Declaration establishment AAORIA facilitate Ocean. announcement will two specific initiatives, one focused other observing, might opportunities STI across (https://allatlanticocean.org/news/conclusions-from-the-2023-all-atlantic-ocean-research-and-innovation-alliance-forum/). Biotecmar (https://allatlanticocean.org/wp-content/uploads/2023/07/Marine-Biotechnology-Initiative.pdf) (AORA) Microbiome Working Group (https://www.marinemicrobiome.org/) were launched, respectively, biotechnology Ongoing data collection underway (https://oceandecade.org/actions/observing-and-promoting-atlantic-microbiomes/; https://ocean.si.edu/ocean-life/microbes/marine-microbes; https://www.macumbaproject.eu/; https://jpi-oceans.eu/en/pharmasea; https://oceandecade.org/actions/mission-ocean-microbiomes-tara-microbiomes/; https://triatlas.w.uib.no/; https://www.bluetools-project.eu/; https://marblesproject.eu/). projects bring into European Union (EU)-lead coordinated research projects, Astral (https://www.astral-project.eu/) Innoaqua (https://innoaquaproject.eu/), provided regarding processes, security, aquaculture, how necessary bioeconomy8, 13. addition, strategic shared infrastructure led improved insights. For instance, Geotraces (https://www.geotraces.org/) EU-funded AtlantECO (https://www.atlanteco.eu) relied protocols leverage expensive underexplored Atlantic. increased participation researchers South. accessible capital formation needed, e.g., through multiuser facilities (https://schmidtocean.org/) target programs (http://www.coml.org/). International Center Deep Life Investigation Shanghai Jiao Tong University represents collaborations (https://icdli.sjtu.edu.cn/). Multinational capacity building involved Brazil, Canada, EU, Africa, States Confap-EU, NSERC/Horizon). partnership Confap-EU engaged mutual funding projects. matching funds all required, limiting scientists many partner countries. impediment requirement work "in parallel", issues project codesign execution scientific Atlantic12. AQUAUP BLUEWAYSE, recently implemented under Economy (https://bluepartnership.eu/news/partnership-decides-first-batch-co-funded-projects), aim microbiome-based solutions animal feeding aquaculture. still lack engagement. achieve bioeconomy, strongly advocate area similar what accomplished observing (https://allatlanticocean.org/news/conclusions-from-the-2023-all-atlantic-ocean-research-and-innovation-alliance-forum/), strong network investments capital, infrastructure, research. propose bidirectional exchanges existing partnerships. allow identification needs resources technologies. Capacity may, intelligence, equipment tools, characterized corals reefs14, 15. Artificial open relevant discoveries genes16. Existing FULBRIGHT PROBRAL-CAPES) could prioritize microbiome. requires complex operate Developing sharing its associated costs help Strong geographical sampling biases increase temporal scales An aspect coverage ensure required partnerships17. Overall, presents opportunity go It underpin interdisciplinary benefit broad engagement promoted. (inter)national financial mechanisms should cocreation codevelopment. Meanwhile, would enable truly resource sharing, make accessible, permit ships. seriously hampered funding. Cocreation codevelopment entails not only but nations, levels government. Specific close gaps south governments invest bilaterial multilateral programs. Funding targeted Central America Africa if embracing inclusive Argentina, Colombia, Dominican Republic, Ghana, Morocco, built. Tangible commitments fund particularly F. T. C. acknowledge CAPES, CNPQ, FAPERJ. thank Dr. Kelly D. Goodwin, NOAA Exploration, National Oceanic Atmospheric Administration (NOAA), USA, valuable comments article. results conclusions, well any views opinions expressed herein, those author(s) do necessarily reflect NOAA/OAR Department Commerce. TPM thanks Foundation (UID number 148867).

Язык: Английский

Harnessing marine microbiomes to develop a sustainable, all‐Atlantic bioeconomy DOI Creative Commons
Cristiane C. Thompson, Alice C. Ortmann, Henk Bolhuis

и другие.

mLife, Год журнала: 2024, Номер 3(2), С. 163 - 166

Опубликована: Май 27, 2024

Marine microbiomes are integral to the functioning of a healthy ocean and have potential be key contributors toward an all-Atlantic sustainable blue bioeconomy (Figure 1). New compounds may developed based on these microbiomes. The Atlantic Ocean is biodiversity hotspot. All-Atlantic Research Innovation Alliance (AAORIA) Declaration, signed in 2022 Washington, DC, promising mechanism move forward marine microbiome science, technology, innovation. However, innovation initiatives South require great attention. Here we highlight potential, challenges ahead, initiative. Successful examples around world discussed, suggestions put forward. Microbes including bacteria, archaea, protists, fungi represent majority biomass1. These microbes play central role nutrient cycling, fluxes energy, matter contributing primary production climate change mitigation2. Furthermore, long-term host–microbe co-evolution has allowed (in)vertebrates occupy diverse niches (e.g., deep sea, hydrothermal vents, coral reefs), facilitated by endosymbiotic which established stable partnerships with their hosts3. Tara global survey demonstrated that microbial diversity modulated water mass parameters, such as temperature nutrients4. More recently, Federation identified wealth novel pico-planktonic eukaryotic producers inhabiting oxygen minimum zones5. Simultaneously, databases artificial intelligence tools been for mining microbiomes6. Some developments being carried out collaboration industry expand knowledge While there much more discover about microbiomes, know they important players supporting food webs. We also functional remarkably high support bioeconomy. In this context, believe countries bordering (including representatives from Global North) create meaningful provide investment science needed address several United Nations Sustainable Development Goals. Almost 900 million people affected hunger (http://wfp.org; accessed April 10, 2024). Further pressure traditional agriculture aquaculture practices foreseen due human population increase, estimated approach up 10 billion 2050. responsible annual 88 metric tonnes fish, most produced inland (fresh) waters. Estimates suggest <40% fish derived systems (mariculture). Harvesting wild populations organisms cannot sustainably sufficient additional food. 35.4% stocks overfished 20197. Alternative approaches mariculture coastal urgently required. harness metabolic traits communities augment marine-derived resources8. Saline alternative (https://Simbaproject.eu; https://www.thesaltdoctors.com/). contribute sustainability reducing need freshwater making use less arable land. To promote saline agriculture, different applied high-tech microbiological screening plant growth-promoting genes salt-tolerant microbes. alter root habitats or modify physiology, increasing salt-impacted Microbiomes development low-carbon integrated multitrophic (IMTA). technologies focus developing recycle waste reduce antibiotic carbon emissions8. Biofloc technology (BFT) successfully shrimp aquaculture9. BFT consortia can serve source remediate rearing quality. offer drug discovery10. Antibiotic resistance, emergence new diseases, cancer rates pharmaceuticals public health challenges. Currently, >18,000 natural products environments (microorganisms macroorganisms)11. Of these, over 5000 patented11. 40,000 gene clusters, obtained 35,000 microorganisms macroorganisms, code highly bioactive molecules enzymes. On path, Blue Remediomics Initiative aims develop catalog datasets, medicines, cosmeceuticals, bioproducts (https://www.embl.org/news/science/blueremediomics-harnessing-marine-microbes-to-promote-a-circular-bioeconomy/). some remain poorly characterized. A recent initiative standard methods best (STI) (https://www.frontiersin.org/research-topics/15877/marine-microbiomes-towards-standard-methods-and-best-practices). priorities include measuring sampled regions sea South, quantifying interactions between microbiota, harnessing oceanic insights crucial efforts aimed at driving policy literacy4. series international agreements collaborative Atlantic12 consensus outcome Declaration establishment AAORIA facilitate Ocean. announcement will two specific initiatives, one focused other observing, might opportunities STI across (https://allatlanticocean.org/news/conclusions-from-the-2023-all-atlantic-ocean-research-and-innovation-alliance-forum/). Biotecmar (https://allatlanticocean.org/wp-content/uploads/2023/07/Marine-Biotechnology-Initiative.pdf) (AORA) Microbiome Working Group (https://www.marinemicrobiome.org/) were launched, respectively, biotechnology Ongoing data collection underway (https://oceandecade.org/actions/observing-and-promoting-atlantic-microbiomes/; https://ocean.si.edu/ocean-life/microbes/marine-microbes; https://www.macumbaproject.eu/; https://jpi-oceans.eu/en/pharmasea; https://oceandecade.org/actions/mission-ocean-microbiomes-tara-microbiomes/; https://triatlas.w.uib.no/; https://www.bluetools-project.eu/; https://marblesproject.eu/). projects bring into European Union (EU)-lead coordinated research projects, Astral (https://www.astral-project.eu/) Innoaqua (https://innoaquaproject.eu/), provided regarding processes, security, aquaculture, how necessary bioeconomy8, 13. addition, strategic shared infrastructure led improved insights. For instance, Geotraces (https://www.geotraces.org/) EU-funded AtlantECO (https://www.atlanteco.eu) relied protocols leverage expensive underexplored Atlantic. increased participation researchers South. accessible capital formation needed, e.g., through multiuser facilities (https://schmidtocean.org/) target programs (http://www.coml.org/). International Center Deep Life Investigation Shanghai Jiao Tong University represents collaborations (https://icdli.sjtu.edu.cn/). Multinational capacity building involved Brazil, Canada, EU, Africa, States Confap-EU, NSERC/Horizon). partnership Confap-EU engaged mutual funding projects. matching funds all required, limiting scientists many partner countries. impediment requirement work "in parallel", issues project codesign execution scientific Atlantic12. AQUAUP BLUEWAYSE, recently implemented under Economy (https://bluepartnership.eu/news/partnership-decides-first-batch-co-funded-projects), aim microbiome-based solutions animal feeding aquaculture. still lack engagement. achieve bioeconomy, strongly advocate area similar what accomplished observing (https://allatlanticocean.org/news/conclusions-from-the-2023-all-atlantic-ocean-research-and-innovation-alliance-forum/), strong network investments capital, infrastructure, research. propose bidirectional exchanges existing partnerships. allow identification needs resources technologies. Capacity may, intelligence, equipment tools, characterized corals reefs14, 15. Artificial open relevant discoveries genes16. Existing FULBRIGHT PROBRAL-CAPES) could prioritize microbiome. requires complex operate Developing sharing its associated costs help Strong geographical sampling biases increase temporal scales An aspect coverage ensure required partnerships17. Overall, presents opportunity go It underpin interdisciplinary benefit broad engagement promoted. (inter)national financial mechanisms should cocreation codevelopment. Meanwhile, would enable truly resource sharing, make accessible, permit ships. seriously hampered funding. Cocreation codevelopment entails not only but nations, levels government. Specific close gaps south governments invest bilaterial multilateral programs. Funding targeted Central America Africa if embracing inclusive Argentina, Colombia, Dominican Republic, Ghana, Morocco, built. Tangible commitments fund particularly F. T. C. acknowledge CAPES, CNPQ, FAPERJ. thank Dr. Kelly D. Goodwin, NOAA Exploration, National Oceanic Atmospheric Administration (NOAA), USA, valuable comments article. results conclusions, well any views opinions expressed herein, those author(s) do necessarily reflect NOAA/OAR Department Commerce. TPM thanks Foundation (UID number 148867).

Язык: Английский

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