Frontiers in Neurology,
Год журнала:
2018,
Номер
9
Опубликована: Фев. 8, 2018
Light
exerts
a
wide
range
of
effects
on
mammalian
physiology
and
behaviour.
As
well
as
synchronising
circadian
rhythms
to
the
external
environment,
light
has
been
shown
modulate
autonomic
neuroendocrine
responses
regulating
sleep
influencing
cognitive
processes
such
attention,
arousal
performance.
The
last
two
decades
have
seen
major
advances
in
our
understanding
retinal
photoreceptors
that
mediate
these
non-image
forming
light,
neural
pathways
molecular
mechanisms
by
which
are
generated
entrained
light/dark
(LD)
cycle.
By
contrast,
lighting
influences
more
equivocal.
different
complex.
direct
indirect
may
also
occur
due
disrupted
entrainment.
Despite
widespread
use
LD
cycles
study
role
cognition,
experimental
protocols
used
subtly
function
not
comparable.
Moreover,
will
disrupt
alter
physiological
arousal,
both
known
cognition.
Studies
behavioural
assays
dependent
upon
sensory
processes,
contribute
their
variable
findings.
Here
we
propose
studies
addressing
conditions
must
account
for
rhythms,
if
fully
understand
basis
effects.
Science,
Год журнала:
2016,
Номер
354(6315), С. 1004 - 1008
Опубликована: Ноя. 24, 2016
Disruptions
of
normal
circadian
rhythms
and
sleep
cycles
are
consequences
aging
can
profoundly
affect
health.
Accumulating
evidence
indicates
that
disturbances,
which
have
long
been
considered
symptoms
many
neurodegenerative
conditions,
may
actually
drive
pathogenesis
early
in
the
course
these
diseases.
In
this
Review,
we
explore
potential
cellular
molecular
mechanisms
linking
dysfunction
loss
to
diseases,
with
a
focus
on
Alzheimer’s
disease.
We
examine
interplay
between
central
peripheral
rhythms,
clock
gene
function,
maintaining
brain
homeostasis,
discuss
therapeutic
implications.
The
influence
number
key
processes
involved
neurodegeneration,
suggesting
systems
might
be
manipulated
promote
healthy
aging.
Proceedings of the National Academy of Sciences,
Год журнала:
2011,
Номер
109(2), С. 582 - 587
Опубликована: Дек. 19, 2011
Diurnal
variation
in
inflammatory
and
immune
function
is
evident
the
physiology
pathology
of
humans
animals,
but
molecular
mechanisms
mediating
cell
types
that
provide
this
gating
remain
unknown.
By
screening
cytokine
responses
mice
to
endotoxin
challenge
at
different
times
day,
we
reveal
magnitude
response
exhibited
pronounced
temporal
dependence,
yet
only
within
a
subset
proinflammatory
cytokines.
Disruption
circadian
clockwork
macrophages
(primary
effector
cells
innate
system)
by
conditional
targeting
key
clock
gene
(
bmal1
)
removed
all
endotoxin-induced
cultured
vivo.
Loss
was
coincident
with
suppressed
rev-erb
α
expression,
implicating
nuclear
receptor
as
potential
link
between
pathways.
This
finding
confirmed
vivo
vitro
through
genetic
pharmacological
modulation
REV-ERB
activity.
Circadian
lost
−/−
from
these
despite
maintenance
rhythmicity
cells.
Using
human
macrophages,
which
show
oscillations
rhythmic
responses,
demonstrate
administration
synthetic
ligand,
or
knockdown
effective
modulating
production
release
IL-6.
work
demonstrates
macrophage
provides
systemic
endotoxin,
identifies
REV-ERBα
function.
may
therefore
represent
unique
therapeutic
target
disease.
Proceedings of the National Academy of Sciences,
Год журнала:
2016,
Номер
113(10)
Опубликована: Фев. 8, 2016
Significance
Shift
work
is
a
risk
factor
for
hypertension,
inflammation,
and
cardiovascular
disease,
even
after
controlling
traditional
factors.
workers
frequently
undergo
circadian
misalignment
(i.e.,
between
the
endogenous
system
24-h
environmental/behavioral
cycles).
This
has
been
proposed
to
explain,
in
part,
why
shift
disease.
However,
impact
of
per
se
on
blood
pressure
inflammatory
markers
poorly
understood.
We
show—under
highly
controlled
laboratory
conditions—that
short-term
increases
healthy
adults.
Our
findings
may
help
explain
disease
risk.
