Clinica Chimica Acta, Год журнала: 2016, Номер 455, С. 195 - 200
Опубликована: Янв. 9, 2016
Язык: Английский
Plants, Год журнала: 2022, Номер 11(20), С. 2722 - 2722
Опубликована: Окт. 14, 2022
Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels, which can lead to serious consequences such as retinopathy, diabetic neuropathy and cardiovascular disease. One of the most efficient ways reduce postprandial hyperglycemia (PPHG) in diabetes mellitus, especially insulin-independent lower amount that absorbed inhibiting carbohydrate hydrolyzing enzymes digestive system, α-glucosidase α-amylase. α-Glucosidase crucial enzyme catalyzes final stage digestion. As result, inhibitors slow D-glucose release from complex carbohydrates delay absorption, resulting levels control PPHG. Many attempts have been made recent years uncover natural sources build physiologic functional diet or compound for treatment. phytoconstituent identified plants, including alkaloids, flavonoids, anthocyanins, terpenoids, phenolic compounds, glycosides others. The current review focuses on updates different traditional/medicinal plant extracts isolated compounds’ biological activity help development potent therapeutic medications with greater efficacy safety treatment type 2 avoid For this purpose, we provide summary latest scientific literature findings well plant-derived bioactive compounds potential hypoglycemic effects. Moreover, elucidates structural insights key drug target, enzymes, its interaction inhibitors.
Язык: Английский
Процитировано
122
Diabetes & Metabolism Journal, Год журнала: 2022, Номер 46(4), С. 552 - 563
Опубликована: Июль 28, 2022
Recently, medical research using big data has become very popular, and its value increasingly recognized. The Korean National Health Information Database (NHID) is representative of that combines information obtained from the Insurance Service collected for claims reimbursement health care services results general examinations provided to all adults. This database several strengths limitations. Given large size, various laboratory data, questionnaires check-ups, their longitudinal nature, long-term accumulation since 2002, carefully designed studies may provide valuable difficult obtain other forms research. However, consideration possible bias careful interpretation when defining causal relationships also important because were not purposes. After NHID became publicly available, publications based on this have increased explosively, especially in field diabetes metabolism. article reviews history, structure, characteristics NHID. Recent trends database, commonly used operational diagnosis, been introduced. We expect further progress expansion
Язык: Английский
Процитировано
87
Diabetes & Metabolism Journal, Год журнала: 2023, Номер 47(5), С. 575 - 594
Опубликована: Сен. 26, 2023
In May 2023, the Committee of Clinical Practice Guidelines Korean Diabetes Association published revised clinical practice guidelines for adults with diabetes and prediabetes. We incorporated latest research findings through a comprehensive systematic literature review applied them in manner suitable population. These are designed all healthcare providers nationwide, including physicians, experts, certified educators who manage patients or individuals at risk developing diabetes. Based on recent changes international results epidemiological study, recommended age screening has been lowered. collaboration relevant medical societies, recently managing hypertension dyslipidemia have into this guideline. An abridgment containing practical information patient education management clinic was separately.
Язык: Английский
Процитировано
81
BMJ, Год журнала: 2024, Номер unknown, С. e076388 - e076388
Опубликована: Фев. 13, 2024
Abstract Objective To investigate the risk of non-alcoholic fatty liver disease (NAFLD) for cardiovascular and all cause death in patients with type 2 diabetes mellitus (T2DM). Design Nationwide population based study. Setting Longitudinal cohort study Korea. Participants 7 796 763 participants National Health Screening Programme 2009 were divided into three groups on NAFLD status: no (fatty index<30); grade 1 (30≤fatty index<60); index≥60). Median follow-up was 8.13 years. Main outcome measures The primary incident (myocardial infarction, ischaemic stroke) or death. Results Of participants, 6.49% (n=505 763) had T2DM. More T2DM (34.06%) (26.73%) than those without (grade NAFLD: 21.20%; 10.02%). incidence rate (per 1000 person years) increased order NAFLD, rates higher five year absolute (no T2DM: 1.03, 95% confidence interval 1.02 to 1.04, 1.25, 1.24 1.26, respectively; 1.23, 1.22 1.50, 1.48 1.51, 1.42, 1.40 1.45, 2.09, 2.06 2.12, 3.34, 3.27 3.41, 3.68, 3.61 3.74, 3.94, 3.87 4.02, 4.25, 4.18 4.33, 4.66, 4.54 4.78, 5.91, 5.78 6.05, respectively). Patients a NAFLD. Risk differences between Conclusions seems be associated death, even mild group
Язык: Английский
Процитировано
67
Diabetes & Metabolism Journal, Год журнала: 2025, Номер 49(1), С. 24 - 33
Опубликована: Янв. 1, 2025
This study aimed to investigate the prevalence, management, and comorbidities of diabetes mellitus among Korean adults. Data from Korea National Health Nutrition Examination Survey (2019-2022) were analyzed assess treatment, risk factors, diabetes. Comparisons between young older adults with emphasized. Among aged ≥30 years, prevalence is 15.5% during 2021-2022. Of these, 74.7% aware their condition, 70.9% received antidiabetic only 32.4% achieved glycosylated hemoglobin (HbA1c) <6.5%. Moreover, 15.9% met integrated management targets, which included HbA1c <6.5%, blood pressure <140/85 mm Hg, low-density lipoprotein cholesterol <100 mg/dL. In 19 39 was 2.2%. them, 43.3% 34.6% 29.6% Obesity affected 87.1%, 26.9% had both hypertension hypercholesterolemia. ≥65 29.3%, awareness, control rates 78.8%, 75.7%, 31.2%, respectively. Integrated targets (HbA1c <7.5%, hypertension, lipids) by 40.1%. Diabetes remains highly prevalent adults, significant gaps in glycemic, pressure, lipid control. Older show higher awareness treatment but limited outcomes. Young bear a burden obesity comorbidities, alongside low rates. Therefore, early intervention programs, education, strategies tailored younger populations are urgently required.
Язык: Английский
Процитировано
8
Diabetes & Metabolism Journal, Год журнала: 2023, Номер 47(3), С. 347 - 355
Опубликована: Март 29, 2023
This study investigated the changes of fatty liver disease prevalence in general Korean population.This analyzed data from National Health Insurance Service 2009 to 2017 that included individuals aged 20 years or older who had undergone a medical health examination. Fatty was assessed using index (FLI). The severity defined by FLI cutoff, ≥30 as moderate, and ≥60 severe disease.The adults over with (FLI ≥60) increased 13.3% 15.5% (P for trend <0.001). increase prominent men (from 20.5% 24.2%) young age (20 39 years) group 12.8% 16.4%) interaction highest type 2 diabetes mellitus (T2DM, 29.6%) population compared prediabetes normoglycemia (10.0% 21.8%) 2017. statistically T2DM Its more steeply young-aged T2DM, 42.2% 60.1% When applying lower cutoff (≥30) similar results were observed.The has increased. Individuals are young, male, have vulnerable disease.
Язык: Английский
Процитировано
27
Journal of Korean Medical Science, Год журнала: 2024, Номер 39(7)
Опубликована: Янв. 1, 2024
The measurement of health levels and monitoring characteristics trends among populations subgroups are essential for informing evidence-based policy decisions. This study aimed to examine the burden disease in Korea both total population 2020, as well analyze changes from 2008 2020.
Язык: Английский
Процитировано
12
Diabetes & Metabolism Journal, Год журнала: 2024, Номер 48(4), С. 546 - 708
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
12
Healthcare, Год журнала: 2024, Номер 12(3), С. 368 - 368
Опубликована: Янв. 31, 2024
There has been increasing interest in mobile healthcare for diabetes management. However, there remains limited evidence regarding the effectiveness of these applications (apps). This scoping review aimed to evaluate clinical management apps. We used following search terms: “mobile app”, application”, and “diabetes”. included only articles written English published between January 2016 August 2021. identified two, six, four focused on type 1 diabetes, 2 both types, respectively. Five, four, three studies reported apps’ functionality, usability, both, Our findings indicated that apps allowed convenient user experience improved blood sugar levels patients with diabetes. Considering findings, usability must be comprehensively evaluated by using definitions such as ISO9241-11 definition or application rating scale (MARS) when developing diabetes-related For feasibility apps, we recommend HbA1C self-management evaluation variables. Given importance continuous interventions are bound become effective tools patient-led self-management.
Язык: Английский
Процитировано
10
Diabetes & Metabolism Journal, Год журнала: 2025, Номер 49(1), С. 13 - 21
Опубликована: Янв. 1, 2025
The Korean National Health Information Database (NHID), which contains nationwide real-world claims data including sociodemographic data, health care utilization screening and healthcare provider information, is a powerful resource to test various hypotheses. It also longitudinal in nature due the recommended checkup every 2 years appropriate for long-term follow-up study as well evaluating relationships between outcomes changes parameters such lifestyle factors, anthropometric measurements, laboratory results. However, because these are not collected research purposes, precise operational definitions of diseases required facilitate big analysis using NHID. In this review, we describe characteristics NHID, used related diabetes, introduce representative diabetes-related
Язык: Английский
Процитировано
1