Immunomodulation for accelerated atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus
Autoimmunity Reviews,
Год журнала:
2025,
Номер
unknown, С. 103760 - 103760
Опубликована: Фев. 1, 2025
Язык: Английский
CD8+CD28+PD1− T Cells as a Prognostic Biomarker in Endometrial Cancer
Current Oncology,
Год журнала:
2025,
Номер
32(3), С. 121 - 121
Опубликована: Фев. 21, 2025
Endometrial
cancer
(EC)
is
an
immunogenic
tumor,
with
CD8+
T
cells
playing
a
pivotal
role
in
antitumor
immunity.
Overexpression
of
PD1
suppresses
cell
function
by
inhibiting
CD28,
critical
co-stimulatory
molecule.
Classifying
based
on
and
CD28
expression
provides
valuable
insights
into
the
immune
microenvironment
EC.
Peripheral
blood
samples
from
120
EC
patients
tumor
tissue
81
were
analyzed
via
flow
cytometry.
categorized
according
to
expression,
their
associations
clinical
characteristics
systematically
evaluated.
CD28−/CD8+
PD1+/CD8+
proportions
significantly
associated
several
high-risk
factors,
including
deep
myometrial
invasion,
LVSI,
as
well
metabolic
disorders
such
dyslipidemia.
CD28+PD1−/CD8+
stage,
grade,
inversely
correlated
age,
elevated
hypertension
or
Tumor-infiltrating
grade
multivariate
analysis
identifying
low
independent
predictor
relapse.
In
summary,
CD8+CD28−
CD8+PD1+
are
linked
features
EC,
while
tumor-infiltrating
CD8+CD28+PD1−
serve
key
prognostic
marker
for
Additionally,
CD8+CD28−,
CD8+PD1+,
PBMC
closely
disorders,
emphasizing
potential
biomarkers
interactions
Язык: Английский
T cell aging and exhaustion: Mechanisms and clinical implications
Clinical Immunology,
Год журнала:
2025,
Номер
275, С. 110486 - 110486
Опубликована: Март 20, 2025
Язык: Английский
Immune Cell Dysfunction: A Critical Player in Development of Diabetes Complications
Current Research in Translational Medicine,
Год журнала:
2025,
Номер
unknown, С. 103510 - 103510
Опубликована: Март 1, 2025
Язык: Английский
Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis
Frontiers in Aging,
Год журнала:
2025,
Номер
6
Опубликована: Апрель 10, 2025
Background
Inflammaging,
defined
as
chronic
low-grade
inflammation
associated
with
aging,
is
considered
a
key
factor
in
many
age-related
diseases.
Despite
growing
research,
comprehensive
assessments
of
trends
and
focuses
on
this
field
over
the
past
2
decades
remain
lacking.
Objective
To
comprehensively
analyze
literature
development
trends,
scientific
priorities,
their
evolution
inflammaging
from
2005
to
2024
using
bibliometric
analysis.
Methods
Academic
was
retrieved
Web
Science
Core
Collection.
CiteSpace
software
used
tool
annual
publication
contributing
countries/regions,
leading
research
institutions,
primary
journals,
keyword
co-occurrence,
including
clustering
burst
analysis
field.
Results
The
study
included
1,800
eligible
articles,
demonstrating
consistent
growth
publications
20
years.
United
States
Italy
were
principal
contributors.
University
Bologna
had
highest
publication.
Professor
Claudio
Franceschi
has
been
figure
Journal
shows
that
themes
predominantly
focus
molecular
biology/immunology
medicine/clinical
fields.
Keyword
identifies
major
hotspots
“inflammaging,”
“Crohn’s
disease,”
“periodontitis,”
“immunosenescence,”
“skeletal
muscle,”
“gut
microbiota,”
“Parkinson’s
disease.”
Emerging
term
indicates
shift
specific
inflammatory
diseases
broader
aging
immune
modulation
studies.
Conclusion
This
first
systematic
assessment
reveals
sustained
academic
an
increasingly
deep
focus.
Язык: Английский
The immune health assessment technique of the elderly population and its application and promotion in the prevention and treatment of common aged diseases
Deleted Journal,
Год журнала:
2024,
Номер
1(4), С. 93 - 100
Опубликована: Дек. 1, 2024
Immunosenescence
refers
to
the
phenomenon
in
which
human
immune
system
gradually
degrades
structure
and
function
with
increase
of
age.
The
mechanism
immunosenescence
is
complex,
involving
systematic
changes
multiple
cell
populations
molecular
markers.
At
present,
there
a
significant
lack
data
on
characteristics
whole
population
China,
limits
comprehensive
understanding
law
elderly
formulation
effective
coping
strategies.
To
accurately
assess
health
status
population,
integrated
application
multiomics
technology
informatics
can
help
scientists
understand
age
detail
depict
characteristic
map
immunosenescence,
not
only
helps
aging
but
also
provides
potential
targets
for
development
intervention
measures
age-related
diseases.
Moreover,
it
provide
scientific
basis
management
formulate
more
prevention
treatment
strategies,
solid
public
policies
our
country
future.
Язык: Английский