The immune health assessment technique of the elderly population and its application and promotion in the prevention and treatment of common aged diseases DOI
Qing Li, Ling‐bing Meng

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(4), P. 93 - 100

Published: Dec. 1, 2024

Immunosenescence refers to the phenomenon in which human immune system gradually degrades structure and function with increase of age. The mechanism immunosenescence is complex, involving systematic changes multiple cell populations molecular markers. At present, there a significant lack data on characteristics whole population China, limits comprehensive understanding law elderly formulation effective coping strategies. To accurately assess health status population, integrated application multiomics technology informatics can help scientists understand age detail depict characteristic map immunosenescence, not only helps aging but also provides potential targets for development intervention measures age-related diseases. Moreover, it provide scientific basis management formulate more prevention treatment strategies, solid public policies our country future.

Language: Английский

Immunomodulation for accelerated atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus DOI
Elena Bartoloni, Fabio Cacciapaglia, Gian Luca Erre

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103760 - 103760

Published: Feb. 1, 2025

Language: Английский

Citations

0
CD8+CD28+PD1− T Cells as a Prognostic Biomarker in Endometrial Cancer DOI Creative Commons

Yufei Nie,

Lin Yang, Yanan Zhang

et al.

Current Oncology, Journal Year: 2025, Volume and Issue: 32(3), P. 121 - 121

Published: Feb. 21, 2025

Endometrial cancer (EC) is an immunogenic tumor, with CD8+ T cells playing a pivotal role in antitumor immunity. Overexpression of PD1 suppresses cell function by inhibiting CD28, critical co-stimulatory molecule. Classifying based on and CD28 expression provides valuable insights into the immune microenvironment EC. Peripheral blood samples from 120 EC patients tumor tissue 81 were analyzed via flow cytometry. categorized according to expression, their associations clinical characteristics systematically evaluated. CD28−/CD8+ PD1+/CD8+ proportions significantly associated several high-risk factors, including deep myometrial invasion, LVSI, as well metabolic disorders such dyslipidemia. CD28+PD1−/CD8+ stage, grade, inversely correlated age, elevated hypertension or Tumor-infiltrating grade multivariate analysis identifying low independent predictor relapse. In summary, CD8+CD28− CD8+PD1+ are linked features EC, while tumor-infiltrating CD8+CD28+PD1− serve key prognostic marker for Additionally, CD8+CD28−, CD8+PD1+, PBMC closely disorders, emphasizing potential biomarkers interactions

Language: Английский

Citations

0
T cell aging and exhaustion: Mechanisms and clinical implications DOI
Weiqi Zhang, Dejun Kong,

Xiaohan Zhang

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: 275, P. 110486 - 110486

Published: March 20, 2025

Language: Английский

Citations

0
Immune Cell Dysfunction: A Critical Player in Development of Diabetes Complications DOI

Mohamed J. Saadh,

Omer Qutaiba B. Allela,

Radhwan Abdul Kareem

et al.

Current Research in Translational Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103510 - 103510

Published: March 1, 2025

Language: Английский

Citations

0
Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis DOI Creative Commons
Beier Jiang, Y.C. Dong, Yu Xiong

et al.

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: April 10, 2025

Background Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 decades remain lacking. Objective To comprehensively analyze literature development trends, scientific priorities, their evolution inflammaging from 2005 to 2024 using bibliometric analysis. Methods Academic was retrieved Web Science Core Collection. CiteSpace software used tool annual publication contributing countries/regions, leading research institutions, primary journals, keyword co-occurrence, including clustering burst analysis field. Results The study included 1,800 eligible articles, demonstrating consistent growth publications 20 years. United States Italy were principal contributors. University Bologna had highest publication. Professor Claudio Franceschi has been figure Journal shows that themes predominantly focus molecular biology/immunology medicine/clinical fields. Keyword identifies major hotspots “inflammaging,” “Crohn’s disease,” “periodontitis,” “immunosenescence,” “skeletal muscle,” “gut microbiota,” “Parkinson’s disease.” Emerging term indicates shift specific inflammatory diseases broader aging immune modulation studies. Conclusion This first systematic assessment reveals sustained academic an increasingly deep focus.

Language: Английский

Citations

0
The immune health assessment technique of the elderly population and its application and promotion in the prevention and treatment of common aged diseases DOI
Qing Li, Ling‐bing Meng

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(4), P. 93 - 100

Published: Dec. 1, 2024

Immunosenescence refers to the phenomenon in which human immune system gradually degrades structure and function with increase of age. The mechanism immunosenescence is complex, involving systematic changes multiple cell populations molecular markers. At present, there a significant lack data on characteristics whole population China, limits comprehensive understanding law elderly formulation effective coping strategies. To accurately assess health status population, integrated application multiomics technology informatics can help scientists understand age detail depict characteristic map immunosenescence, not only helps aging but also provides potential targets for development intervention measures age-related diseases. Moreover, it provide scientific basis management formulate more prevention treatment strategies, solid public policies our country future.

Language: Английский

Citations

0