Trends in Microbiology, Год журнала: 2023, Номер 32(2), С. 107 - 110
Опубликована: Ноя. 10, 2023
Язык: Английский
Metabolites, Год журнала: 2022, Номер 12(11), С. 1064 - 1064
Опубликована: Ноя. 3, 2022
The gut-brain axis is a bidirectional communication network connecting the gastrointestinal tract and central nervous system. keeps track of activities integrates them to connect gut health higher cognitive parts brain. Disruption in this connection may facilitate various neurological problems. Neurodegenerative diseases are characterized by progressive dysfunction specific populations neurons, determining clinical presentation. Misfolded protein aggregates that cause cellular toxicity aid collapse proteostasis defining characteristic neurodegenerative proteinopathies. These disorders not only caused changes neural compartment but also due other factors non-neural origin. Mounting data reveal majority (GI) physiologies mechanics governed system (CNS). Furthermore, microbiota plays critical role regulation physiological function brain, although mechanism involved has yet been fully interpreted. One emerging explanations start progression many illnesses dysbiosis microbial makeup. present understanding literature surrounding relationship between intestinal emergence certain diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis, main emphasis review. potential entry pathway pathogen-associated secretions toxins into CNS explored article at outset neuropathology. We have included possible undelaying synergistic effect infections, their metabolites, interactions based on current understanding.
Язык: Английский
Процитировано
73
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Май 24, 2024
Abstract Aging is a complex and multifaceted process involving variety of interrelated molecular mechanisms cellular systems. Phenotypically, the biological aging accompanied by gradual loss function systemic deterioration multiple tissues, resulting in susceptibility to aging-related diseases. Emerging evidence suggests that closely associated with telomere attrition, DNA damage, mitochondrial dysfunction, nicotinamide adenine dinucleotide levels, impaired macro-autophagy, stem cell exhaustion, inflammation, protein balance, deregulated nutrient sensing, altered intercellular communication, dysbiosis. These age-related changes may be alleviated intervention strategies, such as calorie restriction, improved sleep quality, enhanced physical activity, targeted longevity genes. In this review, we summarise key historical progress exploration important causes anti-aging strategies recent decades, which provides basis for further understanding reversibility phenotypes, application prospect synthetic biotechnology therapy also prospected.
Язык: Английский
Процитировано
68
Neural Regeneration Research, Год журнала: 2023, Номер 19(4), С. 833 - 845
Опубликована: Авг. 14, 2023
A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.
Язык: Английский
Процитировано
31
Gut Microbes, Год журнала: 2023, Номер 15(2)
Опубликована: Дек. 12, 2023
Aging is an inevitable natural process that impacts every individual, and understanding its effect on the gut microbiome dendritic cell (DC) functionality in elderly subjects crucial. DCs are vital antigen-presenting cells (APCs) orchestrate immune response, maintaining tolerance to self-antigens bridging innate adaptive immunity. With aging, there a shift toward nonspecific immunity, resulting decline responses. This alteration raises significant concerns about managing health of population. However, precise impact aging changes DC function their implications lung-associated diseases remain relatively understudied. To illuminate this subject, we will discuss recent advancements connections between dysbiosis, DCs, lung diseases. Emphasizing key concepts linking age-related functions, focus relevance overall response individuals. article aims improve our intricate relationship microbiome, potentially benefiting management age-associated promoting healthy aging.
Язык: Английский
Процитировано
28
Gut Microbes, Год журнала: 2024, Номер 16(1)
Опубликована: Янв. 18, 2024
Trillions of microbes live symbiotically in the host, specifically mucosal tissues such as gut. Recent advances metagenomics and metabolomics have revealed that gut microbiota plays a critical role regulation host immunity metabolism, communicating through bidirectional interactions microbiota-gut-brain axis (MGBA). The regulates both systemic contributes to neurodevelopment behaviors host. With aging, composition changes, emerging studies linked these shifts microbial populations age-related neurological diseases (NDs). Preclinical demonstrated microbiota-targeted therapies can improve behavioral outcomes by modulating microbial, metabolomic, immunological profiles. In this review, we discuss pathways brain-to-gut or gut-to-brain signaling summarize metabolites across lifespan disease. We highlight recent investigating 1) changes with aging; 2) how aging maternal microbiome affect offspring health; 3) contribution chronic (e.g., Parkinson's disease, Alzheimer's disease cerebral amyloidosis), acute brain injury, including ischemic stroke traumatic injury.
Язык: Английский
Процитировано
17
Experimental Gerontology, Год журнала: 2024, Номер 194, С. 112497 - 112497
Опубликована: Июнь 27, 2024
The gut microbiome plays a crucial role in host health throughout the lifespan by influencing brain function during aging. microbial diversity of human decreases aging process and, as consequence, several mechanisms increase, such oxidative stress, mitochondrial dysfunction, inflammatory response, and dysbiosis. Moreover, evidence indicates that neurodegeneration are closely related; consequently, may serve novel marker elderly. In this narrative study, we investigated how changes composition occur influence to various neuropathological disorders, mild cognitive impairment (MCI), dementia, Alzheimer's disease (AD), Parkinson's (PD); which possible govern relationship between impairment. addition, studies suggest be potential target improve hallmarks promote healthy cognition; therefore, current future therapeutic interventions have been also reviewed.
Язык: Английский
Процитировано
13
Nutrients, Год журнала: 2024, Номер 16(6), С. 852 - 852
Опубликована: Март 15, 2024
Background: The gut microbiota in healthy older individuals typically show a decrease beneficial bacteria like Bifidobacterium and Lactobacillus, alongside an increase pro-inflammatory microbes such as Enterobacteriaceae Clostridia. These changes contrast with younger middle-aged appear to correlate cognitive status. Although there is extensive research on functions cognitively impaired elderly individuals, its impact populations has not been extensively studied. Method: A comprehensive literature search was conducted across PubMed, EBSCO, Web of Science, Scopus databases identify studies exploring the relationship between composition functioning adults. During screening process, each record initially assessed by title, abstract, keywords exclude articles that did align scope this review. Three authors independently screened retrieved records. inclusion criteria included: (1) publication peer-reviewed journals; (2) involving neurologically, cognitively, medically populations; (3) participants identified adults, defined for review aged 45 years due limited number records; (4) analysis microbiota; (5) assessment function. Subsequently, full texts were analyzed determine eligibility. exclusion encompassed: incorrect type; inappropriate sample population; unsuitable study design; absence one or more criteria; based animal research. risk bias performed included using Joanna Briggs Institute (JBI) checklist, ensuring all selected met established quality standards. Results: total 6 eligible from possible 1752 published until March 2024 included. We categorized into two groups their focus: taxonomic alpha diversity, which variety organisms within sample. Additionally, methods assessing cognition: neuropsychological tests physiological measurements, notably electroencephalography (EEG). varying results regarding abundance specific bacterial taxa associations. Notably, certain cognition may vary when at different levels, phylum versus family. Conclusions: Changes elderly, even without impairment diagnosis, could potentially serve early biological markers Alzheimer’s disease other dementias before mild appears.
Язык: Английский
Процитировано
11
Neural Regeneration Research, Год журнала: 2024, Номер 20(4), С. 990 - 1008
Опубликована: Апрель 16, 2024
With the rapidly aging human population, age-related cognitive decline and dementia are becoming increasingly prevalent worldwide. Aging is considered main risk factor for acts through alterations in composition of gut microbiota, microbial metabolites, functions astrocytes. The microbiota–gut–brain axis has been focus multiple studies closely associated with function. This article provides a comprehensive review specific changes that occur microbiota metabolites older individuals discusses how astrocytes reactive astrocytosis related to neurodegenerative diseases. also summarizes components affect astrocyte function, mainly vagus nerve, immune responses, circadian rhythms, metabolites. Finally, this mechanism by which microbiota–astrocyte plays role Alzheimer’s Parkinson’s Our findings have revealed critical decline, aiding deeper understanding potential microbiome-based adjuvant therapy strategies condition.
Язык: Английский
Процитировано
11
Aging Cell, Год журнала: 2024, Номер 23(8)
Опубликована: Май 9, 2024
Abstract Aging is associated with low‐grade inflammation that increases the risk of infection and disease, yet underlying mechanisms remain unclear. Gut microbiota composition shifts age, harboring microbes varied immunogenic capacities. We hypothesized gut acts as an active driver during aging. Microbiome patterns in aged mice strongly signs bacterial‐induced barrier disruption immune infiltration, including marked increased levels circulating lipopolysaccharide (LPS)‐binding protein (LBP) colonic calprotectin. Ex vivo immunogenicity assays revealed both contents mucosa harbored capacity to activate toll‐like receptor 4 (TLR4) whereas TLR5 signaling was unchanged. found elevated innate inflammatory (colonic Il6 , Tnf Tlr4 ) endotoxemia (circulating LBP) young germ‐free after weeks colonization intestinal from compared counterparts, thus providing a direct link between aging‐induced host inflammation. Additionally, we discovered exhibited unique responses broad‐spectrum antibiotic challenge (Abx), sustained elevation Escherichia (Proteobacteria) altered 7 days post‐Abx cessation. Together, these data indicate old age results differentially on TLR pathways system. age‐associated signatures are less resilient linked status. should be considered critical factors mediating chronic diseases disproportionally impacting older populations.
Язык: Английский
Процитировано
10
Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102515 - 102515
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
10