Aging and Disease,
Journal Year:
2023,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2023
Lactic
Acid
Bacteria
(LAB)
are
beneficial
microorganisms
widely
utilized
in
food
fermentation
processes
and
as
probiotic
supplements.
They
offer
multifarious
health
benefits,
including
enhancing
digestion,
strengthening
immune
mechanisms,
mitigating
inflammation.
Recent
studies
suggest
that
LAB
might
be
instrumental
the
anti-aging
domain,
modulating
key
molecular
pathways
involved
aging
continuum,
such
IL-13,
TNF-α,
mTOR,
IFN-γ,
TGF-β,
AMPK,
GABA.
The
TLR
family,
particularly
TLR2,
appears
pivotal
during
primary
cellular
interactions
with
bacteria
their
byproducts.
Concurrently,
Sirtuin
predominantly
Sirtuin-1,
plays
diverse
roles
upon
stimuli
by
bacterial
components.
potential
benefits
postulated
include
restoring
gut
balance,
antioxidant
potential,
fortifying
cognitive
mental
faculties.
However,
current
body
of
evidence
is
still
embryonic
calls
for
expansive
human
trials
deeper
mechanistic
analyses.
safety
optimal
consumption
metrics
also
warrant
rigorous
evaluation.
Future
research
trajectories
should
identify
specific
strains
potent
properties
unravel
underlying
biological
pathways.
Given
promising
implications,
stand
dietary
contenders
to
foster
healthy
enrich
quality
life
among
elderly
population.
Metabolites,
Journal Year:
2022,
Volume and Issue:
12(11), P. 1064 - 1064
Published: Nov. 3, 2022
The
gut-brain
axis
is
a
bidirectional
communication
network
connecting
the
gastrointestinal
tract
and
central
nervous
system.
keeps
track
of
activities
integrates
them
to
connect
gut
health
higher
cognitive
parts
brain.
Disruption
in
this
connection
may
facilitate
various
neurological
problems.
Neurodegenerative
diseases
are
characterized
by
progressive
dysfunction
specific
populations
neurons,
determining
clinical
presentation.
Misfolded
protein
aggregates
that
cause
cellular
toxicity
aid
collapse
proteostasis
defining
characteristic
neurodegenerative
proteinopathies.
These
disorders
not
only
caused
changes
neural
compartment
but
also
due
other
factors
non-neural
origin.
Mounting
data
reveal
majority
(GI)
physiologies
mechanics
governed
system
(CNS).
Furthermore,
microbiota
plays
critical
role
regulation
physiological
function
brain,
although
mechanism
involved
has
yet
been
fully
interpreted.
One
emerging
explanations
start
progression
many
illnesses
dysbiosis
microbial
makeup.
present
understanding
literature
surrounding
relationship
between
intestinal
emergence
certain
diseases,
such
as
Alzheimer's
disease,
Parkinson's
Huntington's
multiple
sclerosis,
main
emphasis
review.
potential
entry
pathway
pathogen-associated
secretions
toxins
into
CNS
explored
article
at
outset
neuropathology.
We
have
included
possible
undelaying
synergistic
effect
infections,
their
metabolites,
interactions
based
on
current
understanding.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 24, 2024
Abstract
Aging
is
a
complex
and
multifaceted
process
involving
variety
of
interrelated
molecular
mechanisms
cellular
systems.
Phenotypically,
the
biological
aging
accompanied
by
gradual
loss
function
systemic
deterioration
multiple
tissues,
resulting
in
susceptibility
to
aging-related
diseases.
Emerging
evidence
suggests
that
closely
associated
with
telomere
attrition,
DNA
damage,
mitochondrial
dysfunction,
nicotinamide
adenine
dinucleotide
levels,
impaired
macro-autophagy,
stem
cell
exhaustion,
inflammation,
protein
balance,
deregulated
nutrient
sensing,
altered
intercellular
communication,
dysbiosis.
These
age-related
changes
may
be
alleviated
intervention
strategies,
such
as
calorie
restriction,
improved
sleep
quality,
enhanced
physical
activity,
targeted
longevity
genes.
In
this
review,
we
summarise
key
historical
progress
exploration
important
causes
anti-aging
strategies
recent
decades,
which
provides
basis
for
further
understanding
reversibility
phenotypes,
application
prospect
synthetic
biotechnology
therapy
also
prospected.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(4), P. 833 - 845
Published: Aug. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
Gut Microbes,
Journal Year:
2023,
Volume and Issue:
15(2)
Published: Dec. 12, 2023
Aging
is
an
inevitable
natural
process
that
impacts
every
individual,
and
understanding
its
effect
on
the
gut
microbiome
dendritic
cell
(DC)
functionality
in
elderly
subjects
crucial.
DCs
are
vital
antigen-presenting
cells
(APCs)
orchestrate
immune
response,
maintaining
tolerance
to
self-antigens
bridging
innate
adaptive
immunity.
With
aging,
there
a
shift
toward
nonspecific
immunity,
resulting
decline
responses.
This
alteration
raises
significant
concerns
about
managing
health
of
population.
However,
precise
impact
aging
changes
DC
function
their
implications
lung-associated
diseases
remain
relatively
understudied.
To
illuminate
this
subject,
we
will
discuss
recent
advancements
connections
between
dysbiosis,
DCs,
lung
diseases.
Emphasizing
key
concepts
linking
age-related
functions,
focus
relevance
overall
response
individuals.
article
aims
improve
our
intricate
relationship
microbiome,
potentially
benefiting
management
age-associated
promoting
healthy
aging.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 18, 2024
Trillions
of
microbes
live
symbiotically
in
the
host,
specifically
mucosal
tissues
such
as
gut.
Recent
advances
metagenomics
and
metabolomics
have
revealed
that
gut
microbiota
plays
a
critical
role
regulation
host
immunity
metabolism,
communicating
through
bidirectional
interactions
microbiota-gut-brain
axis
(MGBA).
The
regulates
both
systemic
contributes
to
neurodevelopment
behaviors
host.
With
aging,
composition
changes,
emerging
studies
linked
these
shifts
microbial
populations
age-related
neurological
diseases
(NDs).
Preclinical
demonstrated
microbiota-targeted
therapies
can
improve
behavioral
outcomes
by
modulating
microbial,
metabolomic,
immunological
profiles.
In
this
review,
we
discuss
pathways
brain-to-gut
or
gut-to-brain
signaling
summarize
metabolites
across
lifespan
disease.
We
highlight
recent
investigating
1)
changes
with
aging;
2)
how
aging
maternal
microbiome
affect
offspring
health;
3)
contribution
chronic
(e.g.,
Parkinson's
disease,
Alzheimer's
disease
cerebral
amyloidosis),
acute
brain
injury,
including
ischemic
stroke
traumatic
injury.
Experimental Gerontology,
Journal Year:
2024,
Volume and Issue:
194, P. 112497 - 112497
Published: June 27, 2024
The
gut
microbiome
plays
a
crucial
role
in
host
health
throughout
the
lifespan
by
influencing
brain
function
during
aging.
microbial
diversity
of
human
decreases
aging
process
and,
as
consequence,
several
mechanisms
increase,
such
oxidative
stress,
mitochondrial
dysfunction,
inflammatory
response,
and
dysbiosis.
Moreover,
evidence
indicates
that
neurodegeneration
are
closely
related;
consequently,
may
serve
novel
marker
elderly.
In
this
narrative
study,
we
investigated
how
changes
composition
occur
influence
to
various
neuropathological
disorders,
mild
cognitive
impairment
(MCI),
dementia,
Alzheimer's
disease
(AD),
Parkinson's
(PD);
which
possible
govern
relationship
between
impairment.
addition,
studies
suggest
be
potential
target
improve
hallmarks
promote
healthy
cognition;
therefore,
current
future
therapeutic
interventions
have
been
also
reviewed.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(6), P. 852 - 852
Published: March 15, 2024
Background:
The
gut
microbiota
in
healthy
older
individuals
typically
show
a
decrease
beneficial
bacteria
like
Bifidobacterium
and
Lactobacillus,
alongside
an
increase
pro-inflammatory
microbes
such
as
Enterobacteriaceae
Clostridia.
These
changes
contrast
with
younger
middle-aged
appear
to
correlate
cognitive
status.
Although
there
is
extensive
research
on
functions
cognitively
impaired
elderly
individuals,
its
impact
populations
has
not
been
extensively
studied.
Method:
A
comprehensive
literature
search
was
conducted
across
PubMed,
EBSCO,
Web
of
Science,
Scopus
databases
identify
studies
exploring
the
relationship
between
composition
functioning
adults.
During
screening
process,
each
record
initially
assessed
by
title,
abstract,
keywords
exclude
articles
that
did
align
scope
this
review.
Three
authors
independently
screened
retrieved
records.
inclusion
criteria
included:
(1)
publication
peer-reviewed
journals;
(2)
involving
neurologically,
cognitively,
medically
populations;
(3)
participants
identified
adults,
defined
for
review
aged
45
years
due
limited
number
records;
(4)
analysis
microbiota;
(5)
assessment
function.
Subsequently,
full
texts
were
analyzed
determine
eligibility.
exclusion
encompassed:
incorrect
type;
inappropriate
sample
population;
unsuitable
study
design;
absence
one
or
more
criteria;
based
animal
research.
risk
bias
performed
included
using
Joanna
Briggs
Institute
(JBI)
checklist,
ensuring
all
selected
met
established
quality
standards.
Results:
total
6
eligible
from
possible
1752
published
until
March
2024
included.
We
categorized
into
two
groups
their
focus:
taxonomic
alpha
diversity,
which
variety
organisms
within
sample.
Additionally,
methods
assessing
cognition:
neuropsychological
tests
physiological
measurements,
notably
electroencephalography
(EEG).
varying
results
regarding
abundance
specific
bacterial
taxa
associations.
Notably,
certain
cognition
may
vary
when
at
different
levels,
phylum
versus
family.
Conclusions:
Changes
elderly,
even
without
impairment
diagnosis,
could
potentially
serve
early
biological
markers
Alzheimer’s
disease
other
dementias
before
mild
appears.
Neural Regeneration Research,
Journal Year:
2024,
Volume and Issue:
20(4), P. 990 - 1008
Published: April 16, 2024
With
the
rapidly
aging
human
population,
age-related
cognitive
decline
and
dementia
are
becoming
increasingly
prevalent
worldwide.
Aging
is
considered
main
risk
factor
for
acts
through
alterations
in
composition
of
gut
microbiota,
microbial
metabolites,
functions
astrocytes.
The
microbiota–gut–brain
axis
has
been
focus
multiple
studies
closely
associated
with
function.
This
article
provides
a
comprehensive
review
specific
changes
that
occur
microbiota
metabolites
older
individuals
discusses
how
astrocytes
reactive
astrocytosis
related
to
neurodegenerative
diseases.
also
summarizes
components
affect
astrocyte
function,
mainly
vagus
nerve,
immune
responses,
circadian
rhythms,
metabolites.
Finally,
this
mechanism
by
which
microbiota–astrocyte
plays
role
Alzheimer’s
Parkinson’s
Our
findings
have
revealed
critical
decline,
aiding
deeper
understanding
potential
microbiome-based
adjuvant
therapy
strategies
condition.
Aging Cell,
Journal Year:
2024,
Volume and Issue:
23(8)
Published: May 9, 2024
Abstract
Aging
is
associated
with
low‐grade
inflammation
that
increases
the
risk
of
infection
and
disease,
yet
underlying
mechanisms
remain
unclear.
Gut
microbiota
composition
shifts
age,
harboring
microbes
varied
immunogenic
capacities.
We
hypothesized
gut
acts
as
an
active
driver
during
aging.
Microbiome
patterns
in
aged
mice
strongly
signs
bacterial‐induced
barrier
disruption
immune
infiltration,
including
marked
increased
levels
circulating
lipopolysaccharide
(LPS)‐binding
protein
(LBP)
colonic
calprotectin.
Ex
vivo
immunogenicity
assays
revealed
both
contents
mucosa
harbored
capacity
to
activate
toll‐like
receptor
4
(TLR4)
whereas
TLR5
signaling
was
unchanged.
found
elevated
innate
inflammatory
(colonic
Il6
,
Tnf
Tlr4
)
endotoxemia
(circulating
LBP)
young
germ‐free
after
weeks
colonization
intestinal
from
compared
counterparts,
thus
providing
a
direct
link
between
aging‐induced
host
inflammation.
Additionally,
we
discovered
exhibited
unique
responses
broad‐spectrum
antibiotic
challenge
(Abx),
sustained
elevation
Escherichia
(Proteobacteria)
altered
7
days
post‐Abx
cessation.
Together,
these
data
indicate
old
age
results
differentially
on
TLR
pathways
system.
age‐associated
signatures
are
less
resilient
linked
status.
should
be
considered
critical
factors
mediating
chronic
diseases
disproportionally
impacting
older
populations.
