Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 739, С. 150946 - 150946
Опубликована: Ноя. 6, 2024
Язык: Английский
Neurochemical Research, Год журнала: 2024, Номер 49(4), С. 815 - 833
Опубликована: Янв. 3, 2024
Язык: Английский
Процитировано
6
Molecular Neurobiology, Год журнала: 2024, Номер 61(9), С. 6997 - 7008
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
6
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111331 - 111331
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116761 - 116761
Опубликована: Май 23, 2024
The discovery of regulatory cell death processes has driven innovation in cardiovascular disease (CVD) therapeutic strategies. Over the past decade, ferroptosis, an iron-dependent form regulated by excessive lipid peroxidation, been shown to drive development multiple CVDs. This review provides insights into evolution concept similarities and differences with traditional modes programmed (e.g., apoptosis, autophagy, necrosis), as well core mechanisms ferroptosis (including cystine/glutamate transporter blockade, imbalance iron metabolism, peroxidation). In addition, it not only a detailed role its potential widely studied CVDs such coronary atherosclerotic heart disease, myocardial infarction, ischemia/reperfusion injury, failure, cardiomyopathy, aortic aneurysm but also overview phenomenon perspectives lesser-addressed cardiac valvulopathy, pulmonary hypertension, sickle disease. article aims integrate this knowledge provide comprehensive view wide range progress strategies field.
Язык: Английский
Процитировано
4
Neuroscience Bulletin, Год журнала: 2025, Номер unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Abstract The initiation of calcium oxalate (CaOx) kidney stone formation is highly likely to stem from injury the renal tubular epithelial cells (RTECs) induced by stimulation an aberrant urinary environment. CHAC1 plays a critical role in stress response mechanisms regulating glutathione metabolism. Endoplasmic reticulum (ER) and ferroptosis are demonstrated be involved formation. This study attempted elucidate mechanism ER stress‐dependent CaOx stones. Here, expression performed vivo vitro models. These findings indicated that 4‐Phenylbutyric acid (4‐PBA)treatment deficiency alleviated ferroptotic status, including restoring GSH content, suppressing Fe 2+ lipid peroxidation accumulation, as well ferroptosis‐related proteins. Notably, 4‐PBA treatment both attenuated oxidative damage, improved function, importantly, decreased crystal deposition. Additionally, ChIP‐seq ChIP‐qPCR analyses vital downstream target gene ATF4. results ATF4 depletion inhibited upregulation pro‐ferroptotic Ox stimulation. Overall, ATF4/CHAC1 axis mediating may promising research direction for identifying potential strategy prevent treat
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 149, С. 114150 - 114150
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 21, 2025
Colorectal cancer (CRC) is a serious threat to human health with the third morbidity and second cancer-related mortality worldwide. It urgent explore more effective strategy for CRC because of acquired treatment resistance from non-surgical conventional therapies, including radiation, chemotherapy, targeted therapy immunotherapy. Ferroptosis novel form programmed cell death characterized by iron-dependent lipid peroxidation species (ROS) accumulation has been identified as promising target treatment, especially those resistance. In this review, we mainly summarize recent studies on influence regulation ferroptosis which (including gut microbiota) modulating metabolism iron, amino acid lipid. Thus analysis may provide potential targets inducing shed lights future application in CRC.
Язык: Английский
Процитировано
0
Cell Biology and Toxicology, Год журнала: 2025, Номер 41(1)
Опубликована: Март 25, 2025
Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation lipid peroxides, which has been implicated in pathogenesis various diseases, and therapeutic agents targeting ferroptosis are emerging as promising tools for cancer treatment. Current research reveals that ferroptosis-targeted therapies can effectively inhibit tumor progression or delay development. Notably, natural product-derived compounds-such artemisinin, baicalin, puerarin, quercetin, kaempferol, apigenin-have demonstrated ability to modulate ferroptosis, offering potential anti-cancer benefits. Mechanistically, exhibits negative glutathione peroxidase 4 (GPX4) regulation demonstrates a positive correlation with plasma membrane polyunsaturated fatty acid (PUFA) abundance. Moreover, labile iron pool (LIP) serves redox engine ferroptosis. This review systematically analyzes hallmarks, signaling pathways, molecular mechanisms focus on how small molecules regulate this process. It further evaluates their inducers inhibitors anti-tumor therapy, providing foundation future clinical translation.
Язык: Английский
Процитировано
0
Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111777 - 111777
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0