COVID-19 associates with semen inflammation and sperm quality impairment that reverses in the short term after disease recovery

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Июль 11, 2023

Introduction: COVID-19 exerts deleterious effects on the respiratory, cardiovascular, gastrointestinal, and central nervous systems, causing more severe disease in men than women. However, cumulative reported data about putative consequences male reproductive tract fertility are controversial. Furthermore, long-term of SARS-CoV-2 infection still uncertain. Methods: In this study, we prospectively evaluated levels inflammatory cytokines leukocytes semen sperm quality parameters a cohort 231 reproductive-aged patients, unvaccinated, who had recovered from mild or 62 healthy control individuals. Sperm was assessed early (less 3 months) long (more up to 6 after having COVID-19. Interestingly, unlike most studies, available extensive background baseline patients' allowed performing accurate analysis quality. Results: Significantly higher IL-1β, TNF IFNγ were detected patients recently and/or with respect individuals indicating inflammation. Moreover, showed significantly reduced volume, lower total counts, impaired motility viability. all observed alterations returned values months recovery. Discussion: These results indicate that associates inflammation disease. seems not include detrimental potential since reversible 1-2 spermatogenesis cycles. constitute compelling evidence allowing better understanding associated sequelae, fundamental for collection assisted reproduction.

Язык: Английский

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Does COVID-19 affect sperm quality in males? the answer may be yes, but only temporarily

Virology Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 23, 2024

Abstract Background The Corona Virus Disease 2019 (COVID-19) pandemic has raised concerns regarding its potential impact on male reproductive health. However, the of COVID-19 sperm quality remains uncertain. This retrospective study aimed to investigate short-term and relatively long-term effects infection quality. Methods A total 85 males with fertility requirements, who underwent semen evaluation at Guilin People’s Hospital between June 2022 July 2023, were included in study. Changes parameters analyzed across three specific timeframes: within 6 months before infection, 3 after 3–6 recovery. Results results revealed that concentration number significantly lower compared before, while recovery period, concentration, count, progressive motility, normal morphology increased. Comparing periods, most significant difference was observed which exhibited a decrease but returned levels from COVID-19. Conclusions These findings suggest may exert some quality, particularly evidenced by decreased post-infection. Fortunately, these appear be temporary, gradual restoration further research is needed explore underlying mechanisms implications changes parameters.

Язык: Английский

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Wildfire Smoke Exposure is Associated with Decreased Sperm Concentration and Total Motile Sperm Count

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Introduction As wildfires become more prevalent, their impact on fertility warrants evaluation. We aimed to examine the of smoke exposure semen analysis (SA) parameters intrauterine insemination (IUI) patients in greater Seattle, WA area. hypothesized that wildfire was associated with a decline total motile sperm (TMC). Methods performed retrospective cohort study subjects’ SA pre- and post-exposure 2018, 2020, 2022 events. Pre-exposure diagnostic fresh sample while taken at IUI. If subjects had multiple IUIs during event, only first IUI evaluated. analyses R (Auckland, NZ) using linear mixed-effects modeling (significance p < 0.05) subject event year as random effect account for temporal variations severity. Results identified 84 who underwent across Median time between initial 4 months. observed concentration, sperm, progressively sperm. also an increase percent These trends did not differ year. Conclusions Our results are consistent prior small demonstrating is adverse quality. findings highlight need further research effects human treatments, especially exposures expected climate change. Highlights Minimal exists male demonstrate count, count three separate events corroborate those one completed another geographic location

Язык: Английский

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Seminal plasma proteomics of asymptomatic COVID-19 patients reveals disruption of male reproductive function

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Март 21, 2025

A considerable proportion of males suffer from asymptomatic SARS-CoV-2 infection, while the effect on reproductive function and underlying pathomechanisms remain unclear. The total sperm count decreased evidently after yet all semen samples were tested to be RNA negative. Through label‑free quantitative proteomic profiling, a 733 proteins further identified in seminal plasma 11 COVID-19 patients seven uninfected controls. Of 37 differentially expressed proteins, 23 upregulated 14 downregulated group compared with control. Functional annotations Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Reactome showed that these highly enriched inflammation, immunity-related pathways as well spermatogenesis-associated biological process. Four significantly correlated one or more parameters Spearman's coefficient analysis, filtered potential hub interaction network by MCODE Cytohubba algorithms. Furthermore, we verified results Western blot analysis three representative (ITLN1, GSTM2, PSAP) validation cohort. In summary, our study acute could alter protein profile without direct testicular infection consequently lead impaired quality. These novel findings should enlighten physicians about adverse effects male fertility, provide valuable resources for biologists decipher molecular functions.

Язык: Английский

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COVID-19 infection was associated with poor sperm quality: a cross-sectional and longitudinal clinical observation study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 3, 2025

To ascertain whether COVID-19 infection affects sperm quality and measure the scale of effects. A cross sectional study a longitudinal were conducted during SARS-CoV-2 pandemic (from September 7th 2022 to late January 2023) in China. 604 patients participated study; 140 with 149 unaffected natural controls. The included participants who produce semen sample after COVID-19. positive could provide samples before infection. In addition, by two consecutive over same period as controls for study. Conventional parameters including count, motility, morphology more recent such DNA fragmentation index (DFI) chromatin immaturity observed. study, exposure group demonstrated significantly lower total count (159.58 × 106 vs. 185.42 106, P = 0.042), percentage grade sperms (5.37% 8.45%, 0.009), progressive motility (24.74 ± 14.96% 28.73 16.65%, 0.023), (32.04 18.03% 36.91 20.86%, 0.022), higher DFI (17.50% 11.75%, 0.030) than infection, showed (131.80 173.63 Δd -20.49 0.018 ), ( 2.61% 8.50%, -3.18%, < 0.001), (19.82 13.68% 24.88 14.97%, -5.07 11.94%, 0.001) (26.64 17.35% 32.25 18.69%, -5.62 14.30%, (32.10 21.30% 26.49 18.54%, 5.61 13.71%, 0.039) while negative opposite changes. Finally, 59.29% deteriorated concentration, 57.86% 71.43% Grade sperm, 65.00% 69.29% 75.00% DFI, changes all less 40% (P 0.002). was associated poor quality. findings would be useful clinicians manage men fertility problems suffered

Язык: Английский

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Mild COVID-19 Was Not Associated with Impaired IVF Outcomes or Early Pregnancy Loss in IVF Patients

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(18), С. 5265 - 5265

Опубликована: Сен. 6, 2022

Data collection regarding the effects of COVID-19 on reproduction is ongoing. This study examined effect IVF cycle parameters and early pregnancy outcomes. It included two arms: first compared non-exposed cycles to post-SARS-CoV-2 cycles. Sperm were also compared. The second, prospective arm outcomes among patients who contracted during those did not. None vaccinated against SARS-CoV-2. 60 treatment women with confirmed COVID-19, (either same patient before exposure or matched patients). not differ significantly between exposed groups, including number oocytes, endometrial thickness, fertilization rate top-quality embryos. In 11 cycles, male partner had recently recovered: sperm concentration was lower post-exposure: 6.27 million/mL vs. 16.5 pre-exposure (p = 0.008). 189 IVF-achieved pregnancies, loss hospital admissions groups. appears be unaffected by SARS-CoV-2 disease, despite a minor decline in recent recoverees.

Язык: Английский

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COVID-19 and Semen Fluid Parameters, a Retrospective Study from Infertility Clinics

Life, Год журнала: 2022, Номер 12(12), С. 2076 - 2076

Опубликована: Дек. 10, 2022

The study of the effects SARS-CoV-2 infection and/or vaccination on semen fluid analysis (SFA) parameters is still incomplete. aim this to assess effect COVID-19 and sperm for a sample individuals visiting multi-infertility clinics in Jordan. SFA records were collected retrospectively between September November 2021 analyzed using Jamovi software (version 2.2.5 Windows); p-values < 0.05 considered statistically significant. Sperm concentration, progressive motility, normal morphology, liquefaction time, volume, viscosity compared among two data categories. In first category data, from 354 participants separated into four groups: only vaccinated, infected neither nor infected. other category, 49 subjects before their after classified same mentioned groups analyzed. There no significant differences studied second. Nevertheless, concentration was higher vaccinated unvaccinated ones (p = 0.04). It concluded that vaccines have negative parameters.

Язык: Английский

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Effect of SARS-CoV-2 on semen parameters: A meta-analysis of 39 articles from 15 countries

Journal of Global Health, Год журнала: 2024, Номер 14

Опубликована: Авг. 30, 2024

Declining birth rates during the pandemic have led to concerns about potential impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on fertility among men. As previous studies had inconsistent conclusions, we conducted a meta-analysis evaluate effects SARS-CoV-2 semen parameters.

Язык: Английский

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Update on andrological effects of SARS‐CoV‐2 infection and COVID‐19: An overview review

Andrology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Evidence indicates a wide range of andrological alterations in patients with the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection and Coronavirus Disease 2019 (COVID-19).

Язык: Английский

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SARS-CoV-2 infection (COVID-19) and male fertility: Something we should be worried about?

Urologia Journal, Год журнала: 2023, Номер 90(4), С. 726 - 734

Опубликована: Июнь 5, 2023

As of 2021, roughly 5 million deaths were linked to SARS-CoV-2 infection based on World Health Organization estimates. The pandemic takes its staggering death toll, severely affecting the healthcare systems and leading detrimental implications globally. While severe impact respiratory system is well-established, exact effect male reproduction still largely uncharted territory. When it comes gender, men appear more vulnerable compared women. Increasing evidence suggests that COVID-19 adversely affects spermatogenesis hormonal balance in diverse ways. Semen parameters seem be compromised at least temporarily, while long-term worsening needs clarified studies with extended follow-up. For time being, no data support adverse vaccines a male’s reproductive health. In present article, we examine available literature briefly discuss virus fertility. We further provide comprehensive overview current status vaccination potential Ultimately, address need for future well-designed large-scale trials before drawing definite conclusions fecundity.

Язык: Английский

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