Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives

Redox Biology, Год журнала: 2024, Номер 73, С. 103208 - 103208

Опубликована: Май 24, 2024

Recently, numerous studies have reported the interaction between senescence and oxidative stress in cancer. However, there is a lack of comprehensive understanding precise mechanisms involved.

Язык: Английский

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Scientific Advancements in Drug Development and Trials for Urothelial Carcinoma: Insights From the 2023 ASCO-GU Cancers Symposium

Aging and Disease, Год журнала: 2023, Номер 14(6), С. 1953 - 1953

Опубликована: Янв. 1, 2023

Язык: Английский

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Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Numerous research works have emphasized the critical role that circadian rhythm plays in tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment clinical settings is a continuous endeavor. Consequently, to enhance use time-based pharmaceutical therapies oncology, combining existing knowledge on rhythms' roles within TME essential. This perspective elucidates functions rhythms across various stages development, progression, and metastasis. Specifically, aging, angiogenesis, inflammation are implicated modulating TME. Furthermore, exerts profound influence current treatments thereby generates chronotheray manage tumors. From perspective, offers promising opportunities prevention treatment; nevertheless, further study needed address unanswered scientific problems.

Язык: Английский

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CXCL14 in prostate cancer: complex interactions in the tumor microenvironment and future prospects

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 4, 2025

CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles both physiological and pathological processes, including immune regulation tumorigenesis. Recently, the role of tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding effects on tumors, particularly concerning its expression levels tumor tissues influence phenotypes cancer cells. This variability believed to stem from context-dependent nature CXCL14, as different sources secretion within distinct microenvironments may mediate diverse biological effects. Such phenomena also been observed prostate research. Despite foundational understanding cancer, there remains lack comprehensive reviews summarizing specific this systematically analyzing reasons behind complex Therefore, article aims discuss microenvironment explore future research directions potential applications.

Язык: Английский

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Establishment of cancer-associated fibroblasts-related subtypes and prognostic index for prostate cancer through single-cell and bulk RNA transcriptome

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Июнь 3, 2023

Abstract Current evidence indicate that cancer-associated fibroblasts (CAFs) play an important role in prostate cancer (PCa) development and progression. In this study, we identified CAF-related molecular subtypes prognostic index for PCa patients undergoing radical prostatectomy through integrating single-cell bulk RNA sequencing data. We completed analyses using software R 3.6.3 its suitable packages. Through analysis, NDRG2, TSPAN1, PTN, APOE, OR51E2, P4HB, STEAP1 ABCC4 were used to construct gene (CRGPI). These genes could clearly divide the into two TCGA database BCR risk of subtype 1 was 13.27 times higher than 2 with statistical significance. Similar results observed MSKCC2010 GSE46602 cohorts. addtion, molucular independent factor patients. orchestrated CRGPI based on above divided 430 high- low- groups according median value score. found high-risk group had significant low-risk (HR: 5.45). For functional protein secretion highly enriched while snare interactions vesicular transport 1. terms tumor heterogeneity stemness, showd levels TMB 2. addition, activated dendritic cell score Based eight genes, developed constructed a index, which predict prognosis very well.

Язык: Английский

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SKA3 targeted therapies in cancer precision surgery: bridging bench discoveries to clinical applications – review article

International Journal of Surgery, Год журнала: 2024, Номер 110(4), С. 2323 - 2337

Опубликована: Янв. 18, 2024

Spindle and kinetochore-associated complex subunit 3 (SKA3) is a microtubule-binding subcomplex of the outer kinetochore, which plays vital role in proper chromosomal segregation cell division. Recently, SKA3 have been demonstrated its oncogenic tumorigenesis development cancers. In this review, authors comprehensively deciphered human cancer from various aspects, including bibliometrics, pan-cancer analysis, narrative summary. The also provided top 10 predicted drugs targeting SKA3. proposed that was potential target brought new therapeutic opportunities for patients.

Язык: Английский

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A pan-cancer analysis of the oncogenic and immunological roles of transglutaminase 1 (TGM1) in human cancer

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(3)

Опубликована: Март 12, 2024

Abstract Background There is currently a limited number of studies on transglutaminase type 1 (TGM1) in tumors. The objective this study to perform comprehensive analysis across various types cancer determine the prognostic significance TGM1 tumors and investigate its role immune environment. Method Pan-cancer mutational data were retrieved from TCGA database analyzed using R (version 3.6.4) associated software package. expression difference prognosis examined, along with correlation tumor heterogeneity, stemness, mutation landscape, RNA modification. Additionally, relationship between immunity was investigated TIMER method. Results expressed differently normal samples overall survival progression-free time KIRC, ACC, SKCM, LIHC, STES. In LICH, we found negative 6 indicators stemness. frequencies BLCA, KIRC 1.7%, 0.3%, 0.3% respectively. BLCA BRCA, there significant infiltration CD4 + T cells, CD8 neutrophils, dendritic cells. Conclusion has potential serve as both marker drug target.

Язык: Английский

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Comprehensive genomics analysis of aging related gene signature to predict the prognosis and drug resistance of colon adenocarcinoma

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Фев. 28, 2023

Background: Colon adenocarcinoma (COAD) is a heterogeneous tumor and senescence crucial in the occurrence of cancer. This study aimed to identify senescence-based subtypes construct prognostic signature predict prognosis guide immunotherapy or chemotherapy decisions for COAD patients. Methods: Based on single-cell RNA sequencing (scRNA-seq) data 13 samples from Gene Expression Omnibus (GEO) database, we assessed cellular characteristics. Transcriptome data, copy number variations (CNVs) single nucleotide (SNVs) were obtained The Cancer Genome Atlas (TCGA) database. GSE39582 GSE17537 used validation. Senescence identified using unsupervised consensus clustering analysis, was developed univariate Cox analysis least absolute shrinkage selection operator (LASSO). Response risk groups predicted half-maximal inhibitory concentration (IC50) values. We further analyzed relationship between gene expression methylation level. prediction performance by nomogram. Results: Senescence-related pathways highly enriched malignant cells bulk RNA-seq verified senescence. Three identified, which patients clust3 had poorest higher T stage, accompanied with mutation burden (TMB) mutations, activated inflammatory response, more immune cell infiltration, escape tendency. A 11 genes (MFNG, GPRC5B, TNNT1, CCL22, NOXA1, PABPC1L, PCOLCE2, MID2, CPA3, HSPA1A, CALB1) established, accurately lower high Its robustness validated external cohort. Low sensitive small molecule drugs including Erlotinib, Sunitinib, MG-132, CGP-082996, AZ628, Sorafenib, VX-680, Z-LLNle-CHO. Risk score an independent factor nomogram confirmed its reliability. Four (CALB1, TNNT1) significant positive correlation their level, while six (CCL22, MFNG, PCOLCE2) negatively correlated Conclusion: provides novel understanding heterogeneity perspective senescence, develops signatures COAD.

Язык: Английский

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A pan-cancer analysis of the oncogenic and immunological roles of apolipoprotein F (APOF) in human cancer

European journal of medical research, Год журнала: 2023, Номер 28(1)

Опубликована: Июнь 14, 2023

Apolipoprotein F (APOF) has been less studied in cancers. Thus, we aimed to perform a pan-cancer analysis of the oncogenic and immunological effects APOF on human cancer.A standardized TCGA dataset was downloaded. Differential expression, clinical prognosis, genetic mutations, immune infiltration, epigenetic modifications, tumor stemness heterogeneity were analyzed. We conducted all analyses through software R (version 3.6.3) its suitable packages.Overall, found that common cancers differentially expressed between normal samples prognostic-associated BRCA, PRAD, KIRP, LIHC terms overall survival (OS), disease-free (DFS) progression-free (PFS). The Spearman showed mRNA expression negatively correlated with four indexes (DMPss, DNAss, ENHss, EREG-METHss) statistical significance for PRAD positively LIHC. In BRCA patients, negative correlation TMB, MSI, neo, HRD LOH. mutation frequencies 0.3%. infiltration purity patients. associated most TILs LIHC, B cells, CD4+ T neutrophils, macrophages dendritic but CD8+ cells.Our study offered relatively comprehensive understanding roles

Язык: Английский

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Targeting Prolyl 4-Hydroxylase Subunit Beta (P4HB) in Cancer: New Roads to Travel

Aging and Disease, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Prolyl 4-hydroxylase subunit beta (P4HB) can catalyze the formation, breakage and rearrangement of disulfide bonds through two thioredoxin domains, which is important for maintenance oxidizing environment in endoplasmic reticulum. Recently, P4HB has been demonstrated its oncogenic role tumorigenesis development cancers. Therefore, we comprehensively deciphered human cancer from various aspects, including pan-cancer analysis narrative summary. We also provided some possible interacted molecules top 10 predicted drugs targeting to contribute future research. proposed that was a potential target brought new therapeutic opportunities patients.

Язык: Английский

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