DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Nature reviews. Immunology, Год журнала: 2019, Номер 20(2), С. 95 - 112

Опубликована: Сен. 26, 2019

Язык: Английский

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The clearance of dead cells by efferocytosis

Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 21(7), С. 398 - 414

Опубликована: Апрель 6, 2020

Язык: Английский

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DAMPs and NETs in Sepsis

Frontiers in Immunology, Год журнала: 2019, Номер 10

Опубликована: Окт. 30, 2019

Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. Much has been focused on host pathogens mediated through the interaction of pathogen-associated molecular patterns (PAMPs) and pattern recognition receptors (PRRs). PRRs are also activated nuclear, mitochondrial, cytosolic proteins, known as damage-associated (DAMPs) that released from cells during sepsis. Some well described members DAMP family extracellular cold-inducible RNA-binding protein (eCIRP), high mobility group box 1 (HMGB1), histones, adenosine triphosphate (ATP). DAMPs cell inflammasome activation or passively following death. Similarly, neutrophil traps (NETs) neutrophils inflammation. NETs webs DNA decorated with myeloperoxidase, elastase. Although contribute pathogen clearance, excessive NET formation promotes inflammation tissue damage in Here, we review their crosstalk sepsis respect sources, activation, release, function. A clear understating DAMPs, crucial for understanding pathophysiology development novel therapeutics.

Язык: Английский

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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

Cell, Год журнала: 2020, Номер 180(6), С. 1115 - 1129.e13

Опубликована: Март 1, 2020

Язык: Английский

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Release mechanisms of major DAMPs

APOPTOSIS, Год журнала: 2021, Номер 26(3-4), С. 152 - 162

Опубликована: Март 13, 2021

Abstract Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment inflammation and associated with disorders in sepsis cancer. Thus, therapeutically targeting DAMPs has potential to provide novel effective treatments. When establishing anti-DAMP strategies, it is important not only focus on the as inflammatory mediators but also take into account underlying mechanisms of their release from cells tissues. can be released passively by membrane rupture due necrosis/necroptosis, although appear differ between DAMPs. Other types cell death, such apoptosis, pyroptosis, ferroptosis NETosis, contribute DAMP release. In addition, some exported actively live exocytosis secretory lysosomes or exosomes, ectosomes, activation channel pores. Here we review shared DAMP-specific reported literature for high mobility group box 1, ATP, extracellular cold-inducible RNA-binding protein, histones, heat shock proteins, RNAs cell-free DNA.

Язык: Английский

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Cell death due to electroporation – A review

Bioelectrochemistry, Год журнала: 2021, Номер 141, С. 107871 - 107871

Опубликована: Июнь 5, 2021

Exposure of cells to high voltage electric pulses increases transiently membrane permeability through electroporation. Electroporation can be reversible and is used in gene transfer enhanced drug delivery but also lead cell death. resulting death (termed as irreversible electroporation) has been successfully a new non-thermal ablation method soft tissue such tumours or arrhythmogenic heart tissue. Even though the mechanisms influence outcome electroporation-based treatments due use different pulse parameters conditions, these are not elucidated yet. We review after electroporation reported literature, injuries that may repair involved. The knowledge exposure pulses, targets field need identified optimize existing develop techniques medicine, biotechnology, food technology.

Язык: Английский

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Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment

Theranostics, Год журнала: 2021, Номер 11(18), С. 8813 - 8835

Опубликована: Янв. 1, 2021

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated remarkable achievements. However, emerging evidence has shown that chemoresistance is mediated by impairing or bypassing apoptotic cell death. Several novel types of programmed death, such as ferroptosis, necroptosis, pyroptosis, recently been reported to play significant roles in the modulation cancer progression are considered a promising strategy for treatment. Thus, switch between pyroptosis also discussed. Cancer immunotherapy gained increasing attention due breakthroughs immune checkpoint inhibitors; moreover, highly correlated with immunity tumor microenvironment. Compared necroptosis primary mechanism host defense crucial bridging innate adaptive immunity. Furthermore, exerts benefits on immunotherapies, including inhibitors (ICIs) chimeric antigen receptor T-cell therapy (CAR-T). Hence, this review, we elucidate role We summarize potential small molecules nanomaterials target pyroptotic death mechanisms their therapeutic effects cancer.

Язык: Английский

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Macrophages: The Good, the Bad, and the Gluttony

Frontiers in Immunology, Год журнала: 2021, Номер 12

Опубликована: Авг. 12, 2021

Macrophages are dynamic cells that play critical roles in the induction and resolution of sterile inflammation. In this review, we will compile interpret recent findings on plasticity macrophages how these contribute to development non-infectious inflammatory diseases, with a particular focus allergic autoimmune disorders. The inflammation then be examined, emphasizing ability clear apoptotic immune cells. Rheumatoid arthritis (RA) is chronic autoimmune-driven spectrum diseases where persistent results synovial hyperplasia excessive cell accumulation, leading remodeling reduced function affected joints. central pathophysiology RA, driving episodic cycles tissue destruction. RA patients have increased numbers active M1 polarized pro-inflammatory few or inactive M2 type This imbalance macrophage homeostasis main contributor mediators resulting continual activation stromal populations accelerated remodeling. Modulation phenotype remains key therapeutic goal for treatment disease. Intriguingly, intervention glucocorticoids other DMARDs promotes re-polarization an anti-inflammatory phenotype; reprogramming dependent metabolic changes promote phenotypic switching. Allergic asthma associated Th2-polarised airway inflammation, structural large airways, hyperresponsiveness. Macrophage polarization has profound impact pathogenesis, as response allergen exposure regulated by intricate interplay between local factors including cytokines, chemokines danger signals from neighboring Th2-polarized environment characteristic asthma, high levels IL-4 produced locally infiltrating innate lymphoid helper T acquisition alternatively activated M2a macrophages, myriad effects structure. Targeting regulators currently being pursued diseases. re-balancing responses towards pro-resolution thus success response. It long been established apoptosis supports monocyte recruitment sites facilitating subsequent corpse clearance. drives mediates switch polarity macrophages. However, role cell-derived extracellular vesicles (ACdEV) control received remarkably little attention. ACdEV powerful intercellular communication, carrying wealth lipid protein may modulate phenotype, cargo immune-modulating enzymes. such interactions result repair disease different contexts. discuss origin, characterization, activity underlying mechanisms via clearance, order provide new insights into strategies could exploit capabilities agile responsive

Язык: Английский

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Sex differences in severity and mortality from COVID-19: are males more vulnerable?

Biology of Sex Differences, Год журнала: 2020, Номер 11(1)

Опубликована: Сен. 18, 2020

Abstract Coronavirus disease 2019 (COVID-19) has shown high infection and mortality rates all over the world, despite global efforts, there is so far no specific therapy available for COVID-19. Interestingly, while severity of COVID-19 are higher in males than females, underlying molecular mechanisms unclear. In this review, we explore sex-related differences that may be contributing factors to observed male-biased from Males considered weaker sex aspects related endurance control. Studies show viral RNA clearance delayed with A recent study indicated testis can harbor coronavirus, consequently, clearance. However, role involvement needs further research. females a distinct difference immune system responses eliciting stronger pathogens. This major factor load, severity, mortality. addition, hormone milieus could also determinant infections as estrogen immunoenhancing effects testosterone immunosuppressive effects. The sex-specific indicates research on understanding needed. Inclusion both basic clinical trials required provide critical information help better understand outcome therapy.

Язык: Английский

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Mitochondrial dysfunction: mechanisms and advances in therapy

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Май 15, 2024

Abstract Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation disease progression. Particularly, mitochondrial dysfunctions identified many common pathologies, including cardiovascular diseases, neurodegeneration, metabolic syndrome, cancer. However, the multifaceted nature elusive phenotypic threshold dysfunction complicate our understanding contributions to diseases. Nonetheless, these complexities do not prevent mitochondria from being among most important therapeutic targets. In recent years, strategies targeting have continuously emerged transitioned clinical trials. Advanced intervention such as using healthy replenish or replace damaged mitochondria, has shown promise preclinical trials various Mitochondrial components, mtDNA, mitochondria-located microRNA, associated proteins can be potential agents augment function immunometabolic diseases tissue injuries. Here, we review current knowledge pathophysiology concrete examples We also summarize treat perspective dietary supplements targeted therapies, well translational situation related pharmacology agents. Finally, this discusses innovations applications transplantation an advanced promising treatment.

Язык: Английский

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