EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 155, С. 113774 - 113774

Опубликована: Окт. 3, 2022

One of the malignant tumors in women that has involved both developed and developing countries is breast cancer. Similar to other types tumors, cancer cells demonstrate high metastatic nature. Besides, tumor have ability drug resistance. EMT related mechanism metastasis focus current manuscript highlighting function malignancy Breast increase their migration by induction During EMT, N-cadherin vimentin levels increase, E-cadherin decrease mediate EMT-induced invasion. Different kinds anti-cancer agents such as tamoxifen, cisplatin paclitaxel mediates chemoresistance feature cells. Furthermore, correlates with radio-resistance tumor. Clinical aspect reversing preventing chemotherapy or radiotherapy failure patients improving survival time. The anti-tumor suppress can be used for decreasing invasion increasing chemosensitivity lncRNAs, miRNAs factors modulate progression are discussed here.

Язык: Английский

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Progress in targeting PTEN/PI3K/Akt axis in glioblastoma therapy: Revisiting molecular interactions

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114204 - 114204

Опубликована: Янв. 4, 2023

Glioblastoma (GBM) is one of the most malignant cancers central nervous system and due to its sensitive location, surgical resection has high risk therefore, chemotherapy radiotherapy are utilized for treatment. However, chemoresistance radio-resistance other problems in GBM Hence, new therapies based on genes recommended treatment GBM. PTEN a tumor-suppressor operator cancer that inhibits PI3K/Akt/mTOR axis diminishing growth, metastasis drug resistance. In current review, function PTEN/PI3K/Akt progression evaluated. Mutation or depletion leads increase progression. Low expression level mediates poor prognosis by increasing proliferation invasion, promotes malignancy tumor cells. Moreover, loss signaling can result therapy resistance Activation impairs metabolism via glycolysis inhibition. contrast PTEN, PI3K/Akt oncogenic during progression, enhances. shows positive association with pathways similar signaling, regulated non-coding RNAs. upregulation inhibition anti-cancer agents be beneficial interfering This review emphasizes networks related provides insights targeting this effective

Язык: Английский

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Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents

Pharmacological Research, Год журнала: 2022, Номер 187, С. 106568 - 106568

Опубликована: Ноя. 21, 2022

Язык: Английский

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Paclitaxel and docetaxel resistance in prostate cancer: Molecular mechanisms and possible therapeutic strategies

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 160, С. 114392 - 114392

Опубликована: Фев. 15, 2023

Prostate cancer is among most malignant tumors around the world and this urological tumor can be developed as result of genomic mutations their accumulation during progression towards advanced stage. Due to lack specific symptoms in early stages prostate cancer, patients are diagnosed that cells display low response chemotherapy. Furthermore, enhance aggressiveness cells. Docetaxel paclitaxel suggested well-known compounds for chemotherapy they possess a similar function therapy based on inhibiting depolymerization microtubules, impairing balance microtubules subsequent delay cell cycle progression. The aim current review highlight mechanisms docetaxel resistance cancer. When oncogenic factors such CD133 upregulation PTEN tumor-suppressor shows decrease expression, malignancy enhances induce drug resistance. phytochemicals anti-tumor have been utilized suppressing chemoresistance Naringenin lovastatin used enhancing sensitivity. Moreover, nanostructures polymeric micelles nanobubbles delivery decreasing risk development. These subjects highlighted provide new insight reversing

Язык: Английский

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Molecular profile of metastasis, cell plasticity and EMT in pancreatic cancer: a pre-clinical connection to aggressiveness and drug resistance

Cancer and Metastasis Reviews, Год журнала: 2023, Номер 43(1), С. 29 - 53

Опубликована: Июль 15, 2023

Язык: Английский

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LncRNA-miRNA axis in tumor progression and therapy response: An emphasis on molecular interactions and therapeutic interventions

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 154, С. 113609 - 113609

Опубликована: Авг. 27, 2022

Epigenetic factors are critical regulators of biological and pathological mechanisms they could interact with different molecular pathways. Targeting epigenetic has been an idea approach in disease therapy, especially cancer. Accumulating evidence highlighted function long non-coding RNAs (lncRNAs) as cancer initiation development focused on their association downstream targets. microRNAs (miRNAs) the most well-known targets lncRNAs present review focuses lncRNA-miRNA axis malignancy therapy resistance tumors. LncRNA-miRNA regulates cell death such apoptosis autophagy cancers. This affects tumor metastasis via regulating EMT MMPs. Besides, determines sensitivity cells to chemotherapy, radiotherapy immunotherapy. Based studies, can be affected by drugs genetic tools this may affect expression level miRNAs targets, leading suppression/progression. LncRNAs have both tumor-promoting tumor-suppressor functions unique complicated implication therapy. also other signaling networks PI3K/Akt, STAT3, Wnt/β-catenin EZH2 among others. Notably, lncRNA/miRNA considered a signature for diagnosis prognosis

Язык: Английский

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FGFR families: biological functions and therapeutic interventions in tumors

MedComm, Год журнала: 2023, Номер 4(5)

Опубликована: Сен. 23, 2023

Abstract There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When FGFR binds to its ligand, (FGF), it dimerizes and autophosphorylates, thereby activating several key downstream pathways that play an important role in normal physiology, such as the Ras/Raf/mitogen‐activated protein kinase kinase/extracellular signal‐regulated kinase, phosphoinositide 3‐kinase (PI3K)/AKT, phospholipase C gamma/diacylglycerol/protein c, signal transducer activator of transcription pathways. Furthermore, oncogene, genetic alterations were found 7.1% tumors, these include gene amplification, mutations, fusions or rearrangements. Therefore, rearrangements, considered potential biomarkers therapeutic response for tyrosine inhibitors (TKIs). However, is worth noting with increased use, resistance TKIs inevitably develops, well‐known gatekeeper mutations. Thus, overcoming development drug becomes a serious problem. This review mainly outlines family functions, related pathways, agents tumors aim obtaining better outcomes cancer patients changes. The information provided this may provide additional ideas tumor abnormalities.

Язык: Английский

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Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation

ACS Nano, Год журнала: 2023, Номер 17(22), С. 22240 - 22258

Опубликована: Ноя. 15, 2023

Sorafenib, a first-line molecular-target drug for advanced hepatocellular carcinoma (HCC), has been shown to be potent ferroptosis inducer in HCC. However, we found that there was lower level of sorafenib-resistant HCC samples than sorafenib-sensitive samples, suggesting sorafenib resistance may result suppression. Recent reports have long noncoding RNAs (lncRNAs) are involved programmed cell death (PCD), including apoptosis and ferroptosis. This study aimed investigate the roles underlying molecular mechanisms lncRNAs sorafenib-induced cells. Using lncRNA sequencing, identified ferroptosis-related lncRNA, URB1-antisense RNA 1 (AS1), which highly expressed predicted poor survival Furthermore, URB1-AS1 mitigates by inducing ferritin phase separation reducing cellular free iron content. Hypoxia inducible factor (HIF)-1α as key promoting expression Notably, specifically inhibiting with N-acetylgalactosamine (GalNAc)-small interfering (si)URB1-AS1 successfully enhanced sensitivity cells an vivo tumor model. Our uncovered critical role repression ferroptosis, targeting represent potential approach overcome

Язык: Английский

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A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF-κB signaling in inflammatory lung diseases

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 253, С. 126951 - 126951

Опубликована: Сен. 19, 2023

Язык: Английский

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STAT3 signaling in prostate cancer progression and therapy resistance: An oncogenic pathway with diverse functions

Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 158, С. 114168 - 114168

Опубликована: Янв. 3, 2023

The categorization of cancers demonstrates that prostate cancer is the most common malignancy in men and it causes high death annually. Prostate patients are diagnosed mainly via biomarkers such as PSA test show poor prognosis. cells rapidly diffuse into different parts body their metastasis also a reason for death. Current therapies include chemotherapy, surgery radiotherapy well targeted therapy. progression regulated by factors STAT3 signaling among them. Growth cytokines IL-6 can induce shows carcinogenic impact. Activation occurs promotes malignant behavior tumor cells. Induction increases glycolysis proliferation prevents apoptosis. Furthermore, induces EMT mechanism increasing metastasis. stimulates drug resistance limitation current works lack experiment related to role radio-resistance tumor. Calcitriol, capsazepine β-elemonic compounds capable targeting its inhibition In addition natural products, small molecules have been developed

Язык: Английский

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