Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the world. The development and progression of HCC are closely correlated with abnormal regulation non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long (lncRNAs), circular (circRNAs). Important biological pathways cancer biology, cell proliferation, death, metastasis, impacted by these ncRNAs, which modulate gene expression. expression raises possibility that they could be applied new biomarkers for diagnosis, prognosis, treatment targets. Furthermore, controlling genes, miRNAs can function either tumor suppressors or oncogenes. On other hand, lncRNAs play role advancement interacting molecules within cell, which, turn, affects processes chromatin remodeling, transcription, post-transcriptional processes. importance ncRNA-driven regulatory systems being highlighted current research, sheds light on behavior therapy response. This research highlights great potential ncRNAs improve patient outcomes this difficult disease landscape augmenting present methods care through use precision medicine approaches.

Язык: Английский

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Crosstalk between m6A modification and non-coding RNAs in HCC

Cellular Signalling, Год журнала: 2024, Номер 117, С. 111076 - 111076

Опубликована: Фев. 2, 2024

Язык: Английский

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A New Understanding of Long Non-Coding RNA in Hepatocellular Carcinoma—From m6A Modification to Blood Biomarkers

Cells, Год журнала: 2023, Номер 12(18), С. 2272 - 2272

Опубликована: Сен. 14, 2023

With recent advancements in biological research, long non-coding RNAs (lncRNAs) with lengths exceeding 200 nucleotides have emerged as pivotal regulators of gene expression and cellular phenotypic modulation. Despite initial skepticism due to their low sequence conservation levels, significance various processes has become increasingly apparent. We provided an overview lncRNAs discussed defining features modes operation. then explored crucial function the hepatocarcinogenesis process, elucidating complex involvement hepatocellular carcinoma (HCC). The influential role within HCC tumor microenvironment is emphasized, illustrating potential key modulators disease dynamics. also investigated significant influence N6-methyladenosine (m6A) modification on lncRNA HCC, enhancing our understanding both roles upstream regulators. Additionally, promising biomarkers was liver cancer diagnosis, suggesting a novel avenue for future research clinical application. Finally, work underscored dual contributors pathogenesis innovative tools its diagnosis. Existing challenges prospective trajectories are discussed, emphasizing advancing research.

Язык: Английский

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Insight into the regulatory mechanism of m6A modification: From MAFLD to hepatocellular carcinoma

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 177, С. 116966 - 116966

Опубликована: Июнь 20, 2024

In recent years, there has been a significant increase in the incidence of metabolic-associated fatty liver disease (MAFLD), which attributed to increasing prevalence type 2 diabetes mellitus (T2DM) and obesity. MAFLD affects more than one-third adults worldwide, making it most prevalent globally. Moreover, is considered risk factor for hepatocellular carcinoma (HCC), with MAFLD-related HCC cases increasing. Approximately 1 6 patients are believed have MAFLD, nearly 40 % these do not progress cirrhosis, indicating direct transformation from HCC. N6-methyladenosine (m

Язык: Английский

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Deciphering the nexus between long non-coding RNAs and endoplasmic reticulum stress in hepatocellular carcinoma: biomarker discovery and therapeutic horizons

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Окт. 24, 2024

Hepatocellular carcinoma (HCC) remains a significant global health challenge with few effective treatment options. The dysregulation of endoplasmic reticulum (ER) stress responses has emerged as pivotal factor in HCC progression and therapy resistance. Long non-coding RNAs (lncRNAs) play crucial role key epigenetic modifiers this process. Recent research explored how lncRNAs influence ER which turn affects activity HCC. We systematically analyze the current literature to highlight regulatory roles modulating vice versa Our scrutinization highlights dysregulated contribute various facets HCC, including apoptosis resistance, enhanced proliferation, invasion, metastasis, all driven by stress. Moreover, we delve into emerging paradigm lncRNA-miRNA-mRNA axis, elucidating it promising avenue for developing novel biomarkers paving way more personalized options Nevertheless, acknowledge challenges future directions translating these insights clinical practice. In conclusion, our review provides complex mechanisms governing modulation

Язык: Английский

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The epigenetic regulatory network of long noncoding RNAs in hepatocellular carcinoma

Genes & Diseases, Год журнала: 2025, Номер unknown, С. 101534 - 101534

Опубликована: Янв. 1, 2025

Язык: Английский

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Emerging importance of m6A modification in liver cancer and its potential therapeutic role

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2025, Номер unknown, С. 189299 - 189299

Опубликована: Март 1, 2025

Язык: Английский

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Transcription factor KLF9 inhibits the proliferation, invasion, and migration of pancreatic cancer cells by repressing KIAA1522

Asia-Pacific Journal of Clinical Oncology, Год журнала: 2024, Номер 20(3), С. 423 - 432

Опубликована: Март 23, 2024

Pancreatic cancer (PC) has a poor prognosis and high mortality. Kruppel-like factor 9 (KLF9), transcription factor, is aberrantly expressed in various neoplasms. The current study sought to analyze the functional role of KLF9 proliferation, invasion, migration PC cells.

Язык: Английский

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