Bee Pollen Phytochemicals and Nutrients as Unequaled Pool of Epigenetic Regulators: Implications for Age-Related Diseases
Foods,
Год журнала:
2025,
Номер
14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Язык: Английский
Investigating the bidirectional interactions between senotherepeutic agents and human gut microbiota
European Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
unknown, С. 107098 - 107098
Опубликована: Апрель 1, 2025
Biological
ageing
is
a
time-dependent
process
that
has
implications
for
health
and
disease.
Cellular
senescence
key
driver
in
age-related
diseases.
Senotherapeutic
agents
have
been
shown
to
slow
biological
by
eliminating
senescent
mammalian
cells.
Given
the
increasing
awareness
of
gut
microbiome
regulating
human
health,
this
study
aimed
investigate
effects
senotherapeutic
as
pharmacological
interventions
on
microbiota.
In
study,
bidirectional
four
agents,
quercetin,
fisetin,
dasatinib,
sirolimus,
with
microbiota
sourced
from
healthy
donors
were
investigated.
The
results
revealed
quercetin
was
completely
biotransformed
within
six
hours,
while
dasatinib
most
stable
compounds.
Additionally,
metagenomic
analysis
confirmed
all
compounds
increased
abundance
bacterial
species
associated
(e.g.,
Bacteroides
fragilis,
Bifidobacterium
longum,
Veillonella
parvula),
decreased
pathogenic
bacteria
primarily
diseases
Enterococcus
faecalis
Streptococcus
spp.).
findings
provide
comprehensive
understanding
pharmacobiomics
interventions,
highlighting
potential
microbiome-targeted
senolytics
promoting
ageing.
Язык: Английский
Associations between Circulating Biomarkers of One-Carbon Metabolism and Mitochondrial D-Loop Region Methylation Levels
Epigenomes,
Год журнала:
2024,
Номер
8(4), С. 38 - 38
Опубликована: Окт. 9, 2024
One-carbon
metabolism
is
a
critical
pathway
for
epigenetic
mechanisms.
Circulating
biomarkers
of
one-carbon
have
been
associated
with
changes
in
nuclear
DNA
methylation
levels
individuals
affected
by
age-related
diseases.
More
and
more
studies
are
showing
that
even
mitochondrial
(mtDNA)
could
be
methylated.
In
particular,
the
displacement
(D-loop)
region
modulates
gene
expression
replication
mtDNA
and,
when
altered,
can
contribute
to
development
human
illnesses.
However,
no
study
until
now
has
demonstrated
an
association
between
circulating
D-loop
levels.
Язык: Английский
Senolytics Enhance the Longevity of Caenorhabditis elegans by Altering Betaine Metabolism
The Journals of Gerontology Series A,
Год журнала:
2024,
Номер
79(11)
Опубликована: Окт. 22, 2024
Abstract
Aging
triggers
physiological
changes
in
organisms
that
are
tightly
linked
to
metabolic
changes.
Senolytics
targeting
many
fundamental
aging
processes
currently
being
developed.
However,
the
host
response
natural
senescence
and
molecular
mechanism
underlying
antiaging
benefits
of
senolytics
remain
poorly
understood.
In
this
study,
we
investigated
during
based
on
Caenorhabditis
elegans
model
pinpointed
potential
biomarkers
senolytics.
These
results
suggest
age-dependent
occur
C
elegans.
Betaine
was
identified
as
a
crucial
metabolite
process.
We
explored
effects
interventions
by
administering
3
drugs—metformin,
quercetin,
minocycline—to
nematodes.
Notably,
betaine
expression
significantly
increased
under
drug
treatments.
Our
findings
demonstrated
supplementation
extends
lifespan,
primarily
through
pathways
associated
with
forkhead
box
transcription
factor
(FoxO)
signaling
pathway,
p38-mitogen-activated
protein
kinase
(MAPK)
autophagy,
longevity
regulating
target
rapamycin
(mTOR)
pathway.
addition,
autophagy
free
radicals
altered
betaine-treated
Overall,
found
is
critical
extend
lifespan
nematodes
increasing
levels
promoting
antioxidant
activity.
This
finding
suggests
could
be
novel
therapeutic
for
longevity.
Язык: Английский
Autophagy and nutrigenomics: a winning team against chronic disease and tumors
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Дек. 5, 2024
Autophagy,
a
vital
cell
process,
has
garnered
attention
for
its
role
in
various
diseases
and
potential
therapeutic
interventions.
Dysregulation
of
autophagy
contributes
to
conditions
such
as
metabolic
diseases,
neurodegenerative
disorders,
cancer.
In
diabetes,
plays
crucial
islet
β-cell
maintenance
glucose
homeostasis,
offering
targets
intervention.
Nutrigenomics,
which
explores
how
dietary
components
interact
with
the
genome,
emerged
promising
avenue
disease
management.
It
sheds
light
on
diet
influences
gene
expression
cellular
processes,
personalized
approaches
prevention
Studies
have
showed
impact
specific
components,
polyphenols
omega-3
fatty
acids,
suggesting
their
benefits
disorders.
cancer,
autophagy's
dual
either
suppressing
tumorigenesis
or
promoting
cancer
survival
underscores
importance
understanding
modulation
through
Combined
conventional
chemotherapy
drugs,
compounds
show
synergistic
effects
treatment.
Furthermore,
phytochemicals
indicaxanthin
been
found
epigenetically
regulate
genes
involved
autophagy,
novel
insights
into
therapies.
This
comprehensive
review
aim
study
combined
view
nutrigenomics
some
molecules
maintaining
homeostasis
responding
pathological
stimuli.
Overall,
intersection
effect
bioactive
holds
promise
developing
targeted
interventions
emphasizing
significance
Язык: Английский
The role of glycans in personalization of preventive health care
Croatian Medical Journal,
Год журнала:
2024,
Номер
65(3), С. 293 - 297
Опубликована: Июнь 1, 2024
Язык: Английский
Trophic transfer of carbon-14 from algae to zebrafish lead its blending in biomolecules and dysregulating metabolism via isotope effect
National Science Review,
Год журнала:
2024,
Номер
12(1)
Опубликована: Сен. 29, 2024
ABSTRACT
Carbon-14
(C-14)
has
been
a
major
contributor
to
the
human
radioactive
exposure
dose,
as
it
is
released
into
environment
from
nuclear
industry
in
larger
quantities
compared
other
radionuclides.
This
most
abundant
nuclide
enters
biosphere
organically
bound
C-14
(OBC-14),
posing
potential
threat
public
health.
Yet,
remains
unknown
how
this
relatively
low
radiotoxic
induces
health
risks
via
chemical
effects,
such
isotope
effect.
By
establishing
trophic
transfer
model
involving
algae
(Scenedesmus
obliquus),
daphnia
(Daphnia
magna)
and
zebrafish
(Danio
rerio),
we
demonstrate
that
rapid
incorporation
transformation
of
inorganic
by
OBC-14
facilitates
blending
biomolecules
zebrafish.
We
find
internalized
persistently
retained
brain
zebrafish,
affecting
DNA
methylation
causing
alterations
neuropathology.
Global
tracing
metabolomics
with
further
reveals
involvement
various
critical
metabolic
pathways,
including
one-carbon
metabolism
nucleotide
metabolism.
thus
characterize
kinetic
effects
for
12C/14C
key
reactions
these
pathways
through
experiments
density
functional
theory
computations,
showing
isotopic
substitution
carbon
biochemicals
regulates
disrupting
reaction
ratios
effects.
Our
results
suggest
discharged
can
be
biotransformed
impact
providing
new
insights
understanding
risk
C-14,
which
traditionally
considered
nuclide.
Язык: Английский
Evaluating the connection between diet quality, EpiNutrient intake and epigenetic age: an observational study
American Journal of Clinical Nutrition,
Год журнала:
2024,
Номер
120(5), С. 1143 - 1155
Опубликована: Окт. 11, 2024
DNA
methylation
(DNAm)
has
unique
properties
which
makes
it
a
potential
biomarker
for
lifestyle-related
exposures.
Epigenetic
clocks,
particularly
DNAm-based
biological
age
predictors
[epigenetic
(EA)],
represent
an
exciting
new
area
of
clinical
research
and
deviations
EA
from
chronological
acceleration
(EAA)]
have
been
linked
to
overall
health,
age-related
diseases,
environmental
Язык: Английский
Senolytics enhance longevity inCaenorhabditis elegansby altering betaine metabolism
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 20, 2023
ABSTRACT
Aging
triggers
physiological
changes
in
organisms,
which
are
tightly
interlinked
to
metabolic
changes.
Senolytics
being
developed.
However,
responses
natural
senescence
and
the
molecular
intricacies
of
how
senolytics
confer
antiaging
benefits
remain
enigmatic.
We
performed
a
metabolomics
study
on
based
C.elegans
model.
The
results
suggest
that
age-dependent
aging
occur
C.
elegans
.
Betaine
was
identified
as
crucial
metabolite
process.
To
explore
common
pathway
coregulated
by
different
prolonging
nematodes’
lifespan,
we
fed
nematodes
three
drugs
metformin,
quercetin,
minocycline.
Our
data
show
pathways
associated
with
include
forkhead
box
transcription
factor
(FoxO),
p38-mitogen-activated
protein
kinase
(MAPK)
target
rapamycin
(mTOR)
signaling
pathway,
etc.
Three
raised
betaine
levels,
consistent
high
levels
younger
nematode.
Supplement
prolonged
lifespan
via
stimulating
autophagy
improving
antioxidant
capacity.
Altogether,
our
support
proof-of-concept
evidence
at
appropriate
concentrations
can
extend
nematodes.
Язык: Английский