Cellular ROS and Antioxidants: Physiological and Pathological Role

Antioxidants, Год журнала: 2024, Номер 13(5), С. 602 - 602

Опубликована: Май 14, 2024

Reactive oxygen species (ROS) are highly reactive derivatives that include free radicals such as superoxide anion radical (O2•−) and hydroxyl (HO•), well non-radical molecules hydrogen peroxide (H2O2), peroxynitrite (ONOO−), hypochlorous acid (HOCl) [...]

Язык: Английский

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Treatment of liver fibrosis: Past, current, and future

World Journal of Hepatology, Год журнала: 2023, Номер 15(6), С. 755 - 774

Опубликована: Июнь 25, 2023

Liver fibrosis accompanies the progression of chronic liver diseases independent etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated fatty disease. It is commonly associated with injury, inflammation, cell death. characterized by abnormal accumulation extracellular matrix components that are expressed myofibroblasts collagens alpha-smooth actin proteins. Activated hepatic stellate cells contribute to major population myofibroblasts. Many treatments for have been investigated in clinical trials, including dietary supplementation (e.g., vitamin C), biological treatment simtuzumab), drug pegbelfermin natural herbs), genetic regulation non-coding RNAs), transplantation stem hematopoietic cells). However, none these has approved Food Drug Administration. The efficacy can be evaluated histological staining methods, imaging serum biomarkers, well scoring systems, fibrosis-4 index, aspartate aminotransferase platelet ratio, non-alcoholic disease score. Furthermore, reverse slowly frequently impossible advanced or cirrhosis. To avoid life-threatening stage fibrosis, anti-fibrotic treatments, especially combined behavior prevention, treatment, drugs herb medicines, needed. This review summarizes past studies current future fibrosis.

Язык: Английский

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Association between the composite dietary antioxidant index and metabolic dysfunction-associated steatotic liver disease in adults: a cross-sectional study from NHANES 2017–2020

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 14, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a predominant worldwide, lacking approved drugs for clinical intervention at present. The composite dietary antioxidant index (CDAI) is used to assess the anti-inflammatory properties of diets, with higher CDAI indicating greater exposure antioxidants. Therefore, our study aimed explore relationship between and MASLD in order identify potential therapeutic approaches. We collected data from 12,286 participants National Health Nutrition Examination Survey (NHANES) database 2017 2020 analysis. correlation status, controlled attenuation parameter (CAP), stiffness measurement (LSM) was evaluated by adjusting confounding variables using weighted binary logistic regression model, linear restricted cubic spline (RCS) regression. median this − 0.3055 (interquartile range [IQR], 2.299 2.290). population characterized being young, female, income, absence diabetes, non-MASLD. After multivariable adjustment, results model suggested that may be associated decrease CAP values; RCS indicated significant non-linear relationships CAP, LSM, CDAI. corresponding inflection points curves were 0.349, 0.699, 0.174, respectively. further stratification gender, we found significantly females, whereas males, it non-linear, values males 1.325 0.985, decreased values, particularly suggesting intake complex antioxidants ameliorate hepatic steatosis reduce occurrence MASLD. promoting patterns rich an appropriate strategy incidence

Язык: Английский

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Curcumin alleviates zearalenone-induced liver injury in mice by scavenging reactive oxygen species and inhibiting mitochondrial apoptosis pathway

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 277, С. 116343 - 116343

Опубликована: Апрель 23, 2024

Curcumin (CUR) is a compound extracted from turmeric that has variety of functions including antioxidant and anti-inflammatory. As an estrogen-like mycotoxin, zearalenone (ZEN) not only attacks the reproductive system, but also toxic effects on liver. However, whether CUR can alleviate ZEN-induced liver injury remains unclear. This paper aims to investigate protective effect against in mice explore molecular mechanism involved. BALB/c were randomly divided into control (CON) group, group (200 mg/kg b. w. CUR), ZEN (40 ZEN) CUR+ZEN CUR+40 ZEN). 28 d after exposure treatment, blood samples collected for subsequent testing. The results showed reversed hepatocyte swelling necrosis mice. It significantly reduced serum alkaline phosphatase (ALP), alanine aminotransferase (ALT) aspartate (AST) levels (p < 0.05). In addition, hepatic ROS, malondialdehyde, hydrogen peroxide apoptosis Quantitative RT-PCR Western blot expression Bax Caspase3, increase Nrf2, HO-1 NQO1 induced by conclusion, alleviated scavenging ROS inhibiting mitochondrial apoptotic pathway.

Язык: Английский

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Polysaccharide of Atractylodes macrocephala Koidz alleviates NAFLD-induced hepatic inflammation in mice by modulating the TLR4/MyD88/NF-κB pathway

International Immunopharmacology, Год журнала: 2024, Номер 141, С. 113014 - 113014

Опубликована: Авг. 26, 2024

Язык: Английский

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Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A New Sight

Metabolites, Год журнала: 2024, Номер 14(6), С. 325 - 325

Опубликована: Июнь 8, 2024

Epigenetic and metabolic reprogramming alterations are two important features of tumors, their reversible, spatial, temporal regulation is a distinctive hallmark carcinogenesis. Epigenetics, which focuses on gene regulatory mechanisms beyond the DNA sequence, new entry point for tumor therapy. Moreover, drives hepatocellular carcinoma (HCC) initiation progression, highlighting significance metabolism in this disease. Exploring inter-regulatory relationship between epigenetic modification has become one hot directions current research. As viral etiologies have given way to dysfunction-associated steatotic liver disease (MASLD)-induced HCC, it urgent that complex molecular pathways linking them hepatocarcinogenesis be explored. However, how aberrant crosstalk modifications affects MASLD-induced HCC lacks comprehensive understanding. A better understanding linkages necessary improve treatment strategies. For reason, review examines interwoven landscape carcinogenesis context focusing regulating development interactions while also updating advances modification-based therapeutic drugs HCC.

Язык: Английский

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A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Авг. 9, 2024

Due to the pathological production of liver disease in utility particularly complexity, morbidity and mortality including viral hepatitis, fibrosis/cirrhosis hepatocellular carcinoma (HCC) are rapidly increasing worldwide. Considering its insidious onset, rapid progression drug resistance, finding an effective therapy is worthwhile.

Язык: Английский

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Unravelling bisphenol A-induced hepatotoxicity: Insights into oxidative stress, inflammation, and energy dysregulation

Environmental Pollution, Год журнала: 2024, Номер unknown, С. 124922 - 124922

Опубликована: Сен. 1, 2024

Язык: Английский

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Impact of silymarin‐supplemented cookies on liver enzyme and inflammatory markers in non‐alcoholic fatty liver disease patients

Food Science & Nutrition, Год журнала: 2024, Номер 12(10), С. 7273 - 7286

Опубликована: Июль 17, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD) is a growing public health concern characterized by fat accumulation and severe disorders like nonalcoholic steatohepatitis (NASH), which are influenced obesity, inflammatory processes, metabolic pathways. This research investigates the potential of silymarin‐supplemented cookies in managing NAFLD evaluating their impact on enzyme activity, markers, lipid profiles. A clinical trial Lahore, Pakistan, involved 64 patients. Participants were divided into placebo three treatment groups, with latter receiving for 3 months. The study assessed levels at baseline after intervention, utilizing statistical analyses to evaluate differences. profile renal function test (RFT) also measured months each group safety assessment. After months, groups indicated more significant decreases enzymes compared ( p ≤ .05). Treatment showed reductions alanine aminotransferase (ALT) (64.39–49.38 U/L) aspartate (AST) (61.53–45.38 U/L). improvements alkaline phosphatase (ALP) AST/ALT ratio. Additionally, demonstrated reduction markers. decrease C‐reactive protein (CRP) (6.32–3.39 mg/L) erythrocyte sedimentation rate (ESR) (38.72–23.86 mm/h), indicating that individuals may benefit from intervention's benefits lowering inflammation. revealed an intervention significantly improved enzymes, profiles participants, suggesting health.

Язык: Английский

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Gut microbiota and metabolite interface-mediated hepatic inflammation

Immunometabolism, Год журнала: 2024, Номер 6(1), С. e00037 - e00037

Опубликована: Янв. 1, 2024

Immunologic and metabolic signals regulated by gut microbiota relevant metabolites mediate bidirectional interaction between the liver. Gut dysbiosis, due to diet, lifestyle, bile acids, genetic environmental factors, can advance progression of chronic liver disease. Commensal bacteria have both pro- anti-inflammatory effects depending on their species relative abundance in intestine. Components derived from microbiota–diet regulate hepatic innate adaptive immune cells, as well parenchymal significantly impacting inflammation. In this mini review, recent findings specific bacterial with functions regulating inflammation are first reviewed. addition, socioeconomic hormones, genetics that shape profile microbial components function priming or dampening discussed. Finally, current clinical trials evaluating factors manipulate treat disease Overall, discussion mediators contributing will help direct our future studies

Язык: Английский

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