Foods,
Год журнала:
2024,
Номер
13(11), С. 1725 - 1725
Опубликована: Май 31, 2024
Long-term
hepatic
damage
is
associated
with
human
morbidity
and
mortality
owing
to
numerous
pathogenic
factors.
A
variety
of
studies
have
focused
on
improving
liver
health
using
natural
products
herbal
medicines.
We
aimed
investigate
the
effect
enzyme-treated
Zizania
latifolia
ethanol
extract
(ETZL),
which
increases
content
tricin
via
enzymatic
hydrolysis,
for
8
weeks
liver-related
outcomes,
lipid
metabolism,
antioxidant
activity,
fatigue
compared
a
placebo.
Healthy
Korean
adult
males
aged
19–60
years
were
randomized
into
ETZL
treatment
placebo
groups,
alcohol
consumption
was
24.96
28.64
units/week,
respectively.
Alanine
transaminase,
blood
marker
cell
injury,
significantly
decreased
after
baseline
in
group
(p
=
0.004).
After
weeks,
showed
significant
changes
levels
high-density
lipoprotein
steatosis
index
0.028
p
0.004,
respectively).
tended
reduce
antioxidant-activity-related
factors,
total
status,
malondialdehyde,
but
there
no
difference.
In
multidimensional
scale,
reduction
general
total-fatigue-related
values
0.012
0.032,
Taken
together,
8-week
demonstrated
positive
effects
mental
without
adverse
safety-related
parameters.
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 602 - 602
Опубликована: Май 14, 2024
Reactive
oxygen
species
(ROS)
are
highly
reactive
derivatives
that
include
free
radicals
such
as
superoxide
anion
radical
(O2•−)
and
hydroxyl
(HO•),
well
non-radical
molecules
hydrogen
peroxide
(H2O2),
peroxynitrite
(ONOO−),
hypochlorous
acid
(HOCl)
[...]
World Journal of Hepatology,
Год журнала:
2023,
Номер
15(6), С. 755 - 774
Опубликована: Июнь 25, 2023
Liver
fibrosis
accompanies
the
progression
of
chronic
liver
diseases
independent
etiologies,
such
as
hepatitis
viral
infection,
alcohol
consumption,
and
metabolic-associated
fatty
disease.
It
is
commonly
associated
with
injury,
inflammation,
cell
death.
characterized
by
abnormal
accumulation
extracellular
matrix
components
that
are
expressed
myofibroblasts
collagens
alpha-smooth
actin
proteins.
Activated
hepatic
stellate
cells
contribute
to
major
population
myofibroblasts.
Many
treatments
for
have
been
investigated
in
clinical
trials,
including
dietary
supplementation
(e.g.,
vitamin
C),
biological
treatment
simtuzumab),
drug
pegbelfermin
natural
herbs),
genetic
regulation
non-coding
RNAs),
transplantation
stem
hematopoietic
cells).
However,
none
these
has
approved
Food
Drug
Administration.
The
efficacy
can
be
evaluated
histological
staining
methods,
imaging
serum
biomarkers,
well
scoring
systems,
fibrosis-4
index,
aspartate
aminotransferase
platelet
ratio,
non-alcoholic
disease
score.
Furthermore,
reverse
slowly
frequently
impossible
advanced
or
cirrhosis.
To
avoid
life-threatening
stage
fibrosis,
anti-fibrotic
treatments,
especially
combined
behavior
prevention,
treatment,
drugs
herb
medicines,
needed.
This
review
summarizes
past
studies
current
future
fibrosis.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 14, 2024
Abstract
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
has
emerged
as
a
predominant
worldwide,
lacking
approved
drugs
for
clinical
intervention
at
present.
The
composite
dietary
antioxidant
index
(CDAI)
is
used
to
assess
the
anti-inflammatory
properties
of
diets,
with
higher
CDAI
indicating
greater
exposure
antioxidants.
Therefore,
our
study
aimed
explore
relationship
between
and
MASLD
in
order
identify
potential
therapeutic
approaches.
We
collected
data
from
12,286
participants
National
Health
Nutrition
Examination
Survey
(NHANES)
database
2017
2020
analysis.
correlation
status,
controlled
attenuation
parameter
(CAP),
stiffness
measurement
(LSM)
was
evaluated
by
adjusting
confounding
variables
using
weighted
binary
logistic
regression
model,
linear
restricted
cubic
spline
(RCS)
regression.
median
this
−
0.3055
(interquartile
range
[IQR],
2.299
2.290).
population
characterized
being
young,
female,
income,
absence
diabetes,
non-MASLD.
After
multivariable
adjustment,
results
model
suggested
that
may
be
associated
decrease
CAP
values;
RCS
indicated
significant
non-linear
relationships
CAP,
LSM,
CDAI.
corresponding
inflection
points
curves
were
0.349,
0.699,
0.174,
respectively.
further
stratification
gender,
we
found
significantly
females,
whereas
males,
it
non-linear,
values
males
1.325
0.985,
decreased
values,
particularly
suggesting
intake
complex
antioxidants
ameliorate
hepatic
steatosis
reduce
occurrence
MASLD.
promoting
patterns
rich
an
appropriate
strategy
incidence
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
277, С. 116343 - 116343
Опубликована: Апрель 23, 2024
Curcumin
(CUR)
is
a
compound
extracted
from
turmeric
that
has
variety
of
functions
including
antioxidant
and
anti-inflammatory.
As
an
estrogen-like
mycotoxin,
zearalenone
(ZEN)
not
only
attacks
the
reproductive
system,
but
also
toxic
effects
on
liver.
However,
whether
CUR
can
alleviate
ZEN-induced
liver
injury
remains
unclear.
This
paper
aims
to
investigate
protective
effect
against
in
mice
explore
molecular
mechanism
involved.
BALB/c
were
randomly
divided
into
control
(CON)
group,
group
(200
mg/kg
b.
w.
CUR),
ZEN
(40
ZEN)
CUR+ZEN
CUR+40
ZEN).
28
d
after
exposure
treatment,
blood
samples
collected
for
subsequent
testing.
The
results
showed
reversed
hepatocyte
swelling
necrosis
mice.
It
significantly
reduced
serum
alkaline
phosphatase
(ALP),
alanine
aminotransferase
(ALT)
aspartate
(AST)
levels
(p
<
0.05).
In
addition,
hepatic
ROS,
malondialdehyde,
hydrogen
peroxide
apoptosis
Quantitative
RT-PCR
Western
blot
expression
Bax
Caspase3,
increase
Nrf2,
HO-1
NQO1
induced
by
conclusion,
alleviated
scavenging
ROS
inhibiting
mitochondrial
apoptotic
pathway.
Metabolites,
Год журнала:
2024,
Номер
14(6), С. 325 - 325
Опубликована: Июнь 8, 2024
Epigenetic
and
metabolic
reprogramming
alterations
are
two
important
features
of
tumors,
their
reversible,
spatial,
temporal
regulation
is
a
distinctive
hallmark
carcinogenesis.
Epigenetics,
which
focuses
on
gene
regulatory
mechanisms
beyond
the
DNA
sequence,
new
entry
point
for
tumor
therapy.
Moreover,
drives
hepatocellular
carcinoma
(HCC)
initiation
progression,
highlighting
significance
metabolism
in
this
disease.
Exploring
inter-regulatory
relationship
between
epigenetic
modification
has
become
one
hot
directions
current
research.
As
viral
etiologies
have
given
way
to
dysfunction-associated
steatotic
liver
disease
(MASLD)-induced
HCC,
it
urgent
that
complex
molecular
pathways
linking
them
hepatocarcinogenesis
be
explored.
However,
how
aberrant
crosstalk
modifications
affects
MASLD-induced
HCC
lacks
comprehensive
understanding.
A
better
understanding
linkages
necessary
improve
treatment
strategies.
For
reason,
review
examines
interwoven
landscape
carcinogenesis
context
focusing
regulating
development
interactions
while
also
updating
advances
modification-based
therapeutic
drugs
HCC.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 9, 2024
Due
to
the
pathological
production
of
liver
disease
in
utility
particularly
complexity,
morbidity
and
mortality
including
viral
hepatitis,
fibrosis/cirrhosis
hepatocellular
carcinoma
(HCC)
are
rapidly
increasing
worldwide.
Considering
its
insidious
onset,
rapid
progression
drug
resistance,
finding
an
effective
therapy
is
worthwhile.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(10), С. 7273 - 7286
Опубликована: Июль 17, 2024
Abstract
Nonalcoholic
fatty
liver
disease
(NAFLD)
is
a
growing
public
health
concern
characterized
by
fat
accumulation
and
severe
disorders
like
nonalcoholic
steatohepatitis
(NASH),
which
are
influenced
obesity,
inflammatory
processes,
metabolic
pathways.
This
research
investigates
the
potential
of
silymarin‐supplemented
cookies
in
managing
NAFLD
evaluating
their
impact
on
enzyme
activity,
markers,
lipid
profiles.
A
clinical
trial
Lahore,
Pakistan,
involved
64
patients.
Participants
were
divided
into
placebo
three
treatment
groups,
with
latter
receiving
for
3
months.
The
study
assessed
levels
at
baseline
after
intervention,
utilizing
statistical
analyses
to
evaluate
differences.
profile
renal
function
test
(RFT)
also
measured
months
each
group
safety
assessment.
After
months,
groups
indicated
more
significant
decreases
enzymes
compared
(
p
≤
.05).
Treatment
showed
reductions
alanine
aminotransferase
(ALT)
(64.39–49.38
U/L)
aspartate
(AST)
(61.53–45.38
U/L).
improvements
alkaline
phosphatase
(ALP)
AST/ALT
ratio.
Additionally,
demonstrated
reduction
markers.
decrease
C‐reactive
protein
(CRP)
(6.32–3.39
mg/L)
erythrocyte
sedimentation
rate
(ESR)
(38.72–23.86
mm/h),
indicating
that
individuals
may
benefit
from
intervention's
benefits
lowering
inflammation.
revealed
an
intervention
significantly
improved
enzymes,
profiles
participants,
suggesting
health.
Immunometabolism,
Год журнала:
2024,
Номер
6(1), С. e00037 - e00037
Опубликована: Янв. 1, 2024
Immunologic
and
metabolic
signals
regulated
by
gut
microbiota
relevant
metabolites
mediate
bidirectional
interaction
between
the
liver.
Gut
dysbiosis,
due
to
diet,
lifestyle,
bile
acids,
genetic
environmental
factors,
can
advance
progression
of
chronic
liver
disease.
Commensal
bacteria
have
both
pro-
anti-inflammatory
effects
depending
on
their
species
relative
abundance
in
intestine.
Components
derived
from
microbiota–diet
regulate
hepatic
innate
adaptive
immune
cells,
as
well
parenchymal
significantly
impacting
inflammation.
In
this
mini
review,
recent
findings
specific
bacterial
with
functions
regulating
inflammation
are
first
reviewed.
addition,
socioeconomic
hormones,
genetics
that
shape
profile
microbial
components
function
priming
or
dampening
discussed.
Finally,
current
clinical
trials
evaluating
factors
manipulate
treat
disease
Overall,
discussion
mediators
contributing
will
help
direct
our
future
studies