International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 14744 - 14744
Опубликована: Ноя. 25, 2022
Inherited
metabolic
disorders
(IMD)
are
rare
medical
conditions
caused
by
genetic
defects
that
interfere
with
the
body's
metabolism.
The
clinical
phenotype
is
highly
variable
and
can
present
at
any
age,
although
it
more
often
manifests
in
childhood.
number
of
treatable
IMDs
has
increased
recent
years,
making
early
diagnosis
a
better
understanding
natural
history
disease
important
than
ever.
In
this
review,
we
discuss
main
challenges
faced
applying
proteomics
to
study
IMDs,
key
advances
achieved
field
using
tandem
mass
spectrometry
(MS/MS).
This
technology
enables
analysis
large
numbers
proteins
different
body
fluids
(serum,
plasma,
urine,
saliva,
tears)
single
each
sample,
even
be
applied
dried
samples.
MS/MS
thus
emerged
as
tool
choice
for
proteome
characterization
provided
new
insights
into
many
diseases
biological
systems.
last
10
sequential
window
acquisition
all
theoretical
fragmentation
spectra
(SWATH-MS)
an
accurate,
high-resolution
technique
identification
quantification
differentially
expressed
between
healthy
controls
IMD
patients.
Proteomics
particularly
promising
approach
help
obtain
information
on
diseases,
including
biomarkers
aid
underlying
pathophysiology
guide
development
therapies.
Here,
summarize
emerging
proteomic
technologies
current
uses
limitations
identify
quantify
proteins.
Moreover,
describe
use
mechanisms
regulating
complex
phenotypes;
area
research
essential
understand
these
other
human
diseases.
Cancers,
Год журнала:
2023,
Номер
15(15), С. 3837 - 3837
Опубликована: Июль 28, 2023
The
genomics-based
concept
of
precision
medicine
began
to
emerge
following
the
completion
Human
Genome
Project.
In
contrast
evidence-based
medicine,
will
allow
doctors
and
scientists
tailor
treatment
different
subpopulations
patients
who
differ
in
their
susceptibility
specific
diseases
or
responsiveness
therapies.
current
model
was
proposed
precisely
classify
into
subgroups
sharing
a
common
biological
basis
for
more
effective
tailored
achieve
improved
outcomes.
Precision
has
become
term
that
symbolizes
new
age
medicine.
this
review,
we
examine
history,
development,
future
perspective
We
also
discuss
concepts,
principles,
tools,
applications
related
fields.
our
view,
work,
two
essential
objectives
need
be
achieved.
First,
classified
various
subtypes.
Second,
targeted
therapies
must
available
each
disease
subtype.
Therefore,
focused
review
on
progress
meeting
these
objectives.
The
simulation
of
human
intelligence
in
robots
that
are
designed
to
think
and
learn
like
humans
is
known
as
artificial
(AI).
AI
creating
a
world
has
never
been
seen
before.
By
applying
do
jobs
would
otherwise
take
long
time,
have
the
chance
improve
our
planet.
great
potential
genetic
engineering
gene
therapy
research.
powerful
tool
for
new
hypotheses
helping
with
experimental
techniques.
From
previous
data
model,
it
can
help
detection
heredity
gene-related
disorders.
developments
offer
an
excellent
possibility
rational
drug
discovery
design,
eventually
impacting
humanity.
Drug
development
depend
greatly
on
machine
learning
(ML)
technology.
Genetics
not
exception
this
trend,
ML
expected
impact
nearly
every
aspect
experience.
significantly
aided
treatment
various
biomedical
conditions,
including
In
both
basic
applied
research,
deep
-
highly
versatile
branch
enables
autonomous
feature
extraction
increasingly
exploited.
review,
we
cover
broad
spectrum
current
uses
genetics.
enormous
field
genetics,
but
its
advancement
area
may
be
hampered
future
by
lack
knowledge
about
accompanying
difficulties
could
mask
any
possible
benefits
patients.
This
paper
examines
AI's
significance
advancing
precision
disease
treatment,
provides
peek
at
use
clinical
care,
number
existing
clinician
primer
critical
aspects
these
technologies,
makes
predictions
applications
illnesses.
Current Clinical Microbiology Reports,
Год журнала:
2024,
Номер
11(1), С. 18 - 33
Опубликована: Янв. 16, 2024
Abstract
Purpose
of
Review
This
review
provides
an
overview
the
role
dysbiosis
(imbalanced
gut
microbiota)
in
maintenance
host
homeostasis
and
immune
function
summarizes
recent
evidence
connecting
microbiota
to
development
autoimmune
diseases
(ADs)
(such
as
rheumatoid
arthritis,
type
1
diabetes,
systemic
lupus
erythematosus,
multiple
sclerosis,
spondyloarthritis,
irritable
bowel
syndrome).
The
potential
mechanisms
that
underlie
host-microbiota
interaction
are
also
discussed
evaluate
manipulation
a
therapeutic
approach
managing
ADs.
Additionally,
this
addresses
current
challenges
microbiota-host
research
future
recommendations.
Recent
Findings
findings
suggested
pathogenesis
ADs
appears
be
multifaceted
involving
both
genetic
environmental
factors.
Dysbiosis
or
imbalanced
has
been
increasingly
identified
one
main
factors
can
modulate
responses
contribute
Summary
New
highlighted
significance
microbial
etiology
numerous
diseases.
Understanding
relationship
between
host,
however,
goes
beyond
taxonomic
concerns,
demanding
multidisciplinary
efforts
design
new
approaches
take
individual
variances
into
account.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1168 - 1168
Опубликована: Янв. 18, 2024
Alzheimer’s
Disease
(AD)
is
the
most
common
neurodegenerative
disease
which
manifests
with
progressive
cognitive
impairment,
leading
to
dementia.
Considering
noninvasive
collection
of
saliva,
we
designed
systematic
review
answer
question
“Are
salivary
biomarkers
reliable
for
diagnosis
Disease?”
Following
inclusion
and
exclusion
criteria,
30
studies
were
included
in
this
(according
PRISMA
statement
guidelines).
Potential
include
mainly
proteins,
metabolites
even
miRNAs.
Based
on
meta-analysis,
AD
patients,
levels
beta-amyloid42
p-tau
significantly
increased,
t-tau
lactoferrin
decreased
at
borderline
statistical
significance.
However,
according
pooled
AUC,
showed
a
significant
predictive
value
salivary-based
diagnosis.
In
conclusion,
potential
markers
such
as
beta-amyloid42,
tau
can
be
detected
saliva
could
reliably
support
early
disease.
Biomedicines,
Год журнала:
2024,
Номер
12(1), С. 221 - 221
Опубликована: Янв. 18, 2024
This
comprehensive
review
article
delves
into
the
critical
role
of
human
microbiota
in
development
and
management
endocrine-related
diseases.
We
explore
complex
interactions
between
endocrine
system,
emphasizing
implications
dysbiosis
for
onset
progression
various
disorders.
The
aims
to
synthesize
current
knowledge,
highlighting
recent
advancements
potential
novel
therapeutic
approaches
targeting
microbiota-endocrine
interactions.
Key
topics
include
impact
on
hormone
regulation,
its
pathologies,
promising
avenues
modulation
through
diet,
probiotics,
prebiotics,
fecal
transplantation.
underscore
importance
this
research
advancing
personalized
medicine,
offering
insights
more
tailored
effective
treatments
The Scientific World JOURNAL,
Год журнала:
2024,
Номер
2024, С. 1 - 13
Опубликована: Фев. 17, 2024
Biomedical
researchers
tirelessly
seek
cutting-edge
technologies
to
advance
disease
diagnosis,
drug
discovery,
and
therapeutic
interventions,
all
aimed
at
enhancing
human
animal
well-being.
Within
this
realm,
proteomics
stands
out
as
a
pivotal
technology,
focusing
on
extensive
studies
of
protein
composition,
structure,
function,
interactions.
Proteomics,
with
its
subdivisions
expression,
structural,
functional
proteomics,
plays
crucial
role
in
unraveling
the
complexities
biological
systems.
Various
sophisticated
techniques
are
employed
including
polyacrylamide
gel
electrophoresis,
mass
spectrometry
analysis,
NMR
spectroscopy,
microarray,
X-ray
crystallography,
Edman
sequencing.
These
methods
collectively
contribute
comprehensive
understanding
proteins
their
roles
health
disease.
In
biomedical
field,
finds
widespread
application
cancer
research
stem
cell
studies,
diagnosis
both
infectious
noninfectious
diseases.
addition,
it
discovery
emerging
frontier
personalized
medicine.
The
versatility
allows
delve
into
intricacies
molecular
mechanisms,
paving
way
for
innovative
approaches.
As
diseases
continue
emerge
field
expands,
significance
becomes
increasingly
evident.
Keeping
abreast
latest
developments
applications
paramount
development
therapeutics,
translational
research,
study
diverse
This
review
aims
provide
overview
offering
concise
outline
current
domain.
By
doing
so,
seeks
advancement
emphasizing
shaping
future
interventions.
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1586 - 1586
Опубликована: Июль 17, 2024
Fibroblasts
are
typical
mesenchymal
cells
widely
distributed
throughout
the
human
body
where
they
(1)
synthesise
and
maintain
extracellular
matrix,
ensuring
structural
role
of
soft
connective
tissues;
(2)
secrete
cytokines
growth
factors;
(3)
communicate
with
each
other
cell
types,
acting
as
signalling
source
for
stem
niches;
(4)
involved
in
tissue
remodelling,
wound
healing,
fibrosis,
cancer.
This
review
focuses
on
developmental
heterogeneity
dermal
fibroblasts,
their
ability
to
sense
changes
biomechanical
properties
surrounding
aging,
skin
repair,
pathologic
conditions
tumour
development.
Moreover,
we
describe
use
fibroblasts
different
models
(e.g.,
vivo
animal
vitro
systems
from
2D
6D
cultures)
bioengineering
informative
potential
high-throughput
assays
study
under
disease
contexts
personalized
healthcare
regenerative
medicine
applications.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(6), С. 5777 - 5793
Опубликована: Июнь 11, 2024
Traditional
methodologies
often
fall
short
in
addressing
the
complexity
of
biological
systems.
In
this
regard,
system
biology
omics
have
brought
invaluable
tools
for
conducting
comprehensive
analysis.
Current
sequencing
capabilities
revolutionized
genetics
and
genomics
studies,
as
well
characterization
transcriptional
profiling
dynamics
several
species
sample
types.
Biological
systems
experience
complex
biochemical
processes
involving
thousands
molecules.
These
occur
at
different
levels
that
can
be
studied
using
mass
spectrometry-based
(MS-based)
analysis,
enabling
high-throughput
proteomics,
glycoproteomics,
glycomics,
metabolomics,
lipidomics
Here,
we
present
most
up-to-date
techniques
utilized
completion
Additionally,
include
some
interesting
examples
applicability
multi
to
a
variety
