Immunologic aspects of infertility in chronic endometritis
Russian Medical Inquiry,
Год журнала:
2024,
Номер
8(3)
Опубликована: Янв. 1, 2024
Over
the
past
decades,
chronic
endometritis
(CE)
has
been
focus
of
scientists
and
infertility
specialists
due
to
its
potential
association
with
reproductive
disorders.
The
pathogenesis
CE
is
conventionally
associated
impairment
endometrial
commensal
microbiota
pathogenic
microflora
entering
uterus
through
cervical
canal.
A
necessary
prerequisite
for
preserving
female
health
balance
between
local
immunity
endometrium.
To
date,
no
unified
concept
immunopathogenesis
established,
which
precludes
ability
fully
resolve
disorders
arising
from
this
condition.
An
analysis
current
published
data
on
losses
illustrates
necessity
expand
ideas
about
role
immune
in
possibility
optimizing
diagnostic
tools
using
systemic
indicators.
In
light
aforementioned
considerations,
aim
paper
provide
a
comprehensive
review
recent
endometrium
both
healthy
chronically
inflamed
states,
as
well
elucidate
immunological
mechanisms
underlying
CE.
KEYWORDS:
endometrium,
immunity,
endometritis,
infertility,
losses.
FOR
CITATION:
Kolesnikova
N.V.,
Filippov
E.F.
Immunologic
aspects
endometritis.
Russian
Medical
Inquiry.
2024;8(3):155–162
(in
Russ.).
DOI:
10.32364/2587-6821-2024-8-3-6.
Язык: Английский
Personalized approach to pre-graduate preparation in women with chronic endometritis. Case report
GYNECOLOGY,
Год журнала:
2024,
Номер
26(3), С. 275 - 281
Опубликована: Сен. 20, 2024
Over
the
past
few
decades,
attention
of
gynecologists
and
reproductive
specialists
has
been
drawn
to
key
causes
female
infertility,
among
which
chronic
endometritis
(CE)
dominates.
The
aim
paper
is
inform
about
need
for
a
comprehensive
approach
(considering
comorbidities)
diagnose
treat
CE
using
medical
physiotherapeutic
treatment
methods.
article
presents
prospective
review
pregravid
preparation,
considering
features
examination,
verification
diagnosis,
two
patients
with
history
losses
due
CE.
presented
clinical
cases
demonstrate
importance
multidirectional
diagnosis
CE,
mandatory
morphological
examination
verify
as
well
feasibility
prescribing
complex
therapy
both
drug
(antimicrobial
therapy,
immunomodulatory,
hormonal,
combined
broad-spectrum
agents)
methods
treatment.
Язык: Английский
Modulation of female rats steroidogenesis in the application of balneotherapy in an experimental model of chronic endometritis
Fundamental and Clinical Medicine,
Год журнала:
2024,
Номер
9(4), С. 20 - 28
Опубликована: Дек. 25, 2024
Aim.
Assess
steroidogenesis
modulation
efficacy
of
balneotherapy
in
experimental
chronic
endometritis
model.
Materials
and
Мethods.
The
was
induced
laboratory
Wistar
line
rats
(n
=
30)
inoculated
with
intra-uterine
self-fecal
suspension.
Starting
the
3nd
day
experiment,
all
animals
have
recieved
wide-spectrum
antibiotic
within
7
days;
from
41–
group
(n=10)
applying
10
procedures
radon
therapy
one
a
lasting
15
minutes.
Comparison
10)
received
peloid
mud
according
to
regimen.
Control
no
treatment.
venous
estradiol
progesterone
levels
were
analyzed
by
enzyme-linked
immunosorbent
assay.
Histological
verification
conducted
endometrium
histology
study.
Results
.
In
control
it
found
maximal
endometrial
diffuse
infiltrate
180.7
±
9.0
immunocompetent
cells.
During
treatment
density
inflammatory
lower
125.4
8.1
(by
30.7%
vs.
group;
p
0.002),
whereas
comparison
infiltration
minimal
(reduced
88.7
%
compared
<
0.001)
reached
20.5
1.8
Most
pronounced
rise
serum
level
had
resulted
during
(p
0.008),
meanwhile
featured
significant
change
(р
0.95).
Conclusion.
is
accompanied
significantly
increased
decreased
along
markers
regression
which
can
be
used
future
prospective
studies
for
confirming
its
effectiveness
patients
reproductive
system
patology
including
diseases
hyperestrogenism.
Язык: Английский
Diagnosis and methods of treatment of chronic endometritis in women of reproductive age
Women s Health and Reproduction,
Год журнала:
2024,
Номер
61(1)
Опубликована: Янв. 1, 2024
Aim.
To
study
the
controversial
issues
of
diagnosis
and
treatment
chronic
endometritis
(CE)
its
impact
on
fertility,
according
to
foreign
domestic
authors.
Key
points.
Although
immunohistochemical
for
plasma
cells
is
considered
gold
standard
diagnosing
CE,
it
has
limitations.
The
need
achieve
consensus
diagnostic
criteria
cholecystitis
was
noted
in
order
exclude
influence
heterogeneity
studies
assessment
results.
An
integrated
approach
based
knowledge
about
pathogenesis
CE
facilitates
selection
adequate
treatment.
positive
role
antibacterial
therapy
resolving
undoubted.
In
recent
years,
restore
immune
defense
been
widely
discussed.
importance
a
complex
natural
antimicrobial
peptides
cytokines
restoring
fertility
improving
pregnancy
outcomes
already
proven
several
publications.
Physiotherapeutic
methods
continue
be
studied,
most
popular
currently
are
cavitated
solutions,
peloids,
electropulse
magnetic
therapy.
Conclusion.
require
clear
definition.
Treatment
should
include
broad-spectrum
antibiotic
therapy,
immunomodulatory
physiotherapy.
Keywords:
endometritis,
infertility,
recurrent
miscarriage,
antibiotics,
immunomodulators,
peloid
ultrasonic
cavitation,
interference
magnetotherapy,
laser
Язык: Английский