On the trail of pulmonary tuberculosis based on rib lesions: Results from the human identified skeletal collection from the Museu Bocage (Lisbon, Portugal)
American Journal of Physical Anthropology,
Год журнала:
2005,
Номер
130(2), С. 190 - 200
Опубликована: Дек. 19, 2005
Abstract
In
the
last
20
years,
studies
on
human
identified
skeletal
collections
have
revealed
a
significant
relationship
between
new
bone
formation
visceral
surface
of
ribs
and
pulmonary
tuberculosis
(TB).
To
improve
methods
differential
diagnosis
respiratory
diseases
in
archaeological
skeletons,
an
investigation
was
conducted
197
individuals
from
Human
Identified
Skeletal
Collection
Museu
Bocage
(Lisbon,
Portugal).
This
sample
included
109
males
88
females
who
lived
during
19th–20th
centuries,
with
ages
at
death
ranging
13–88
years.
The
skeletons
were
grouped
according
to
cause
death:
1)
TB
(N
=
84);
2)
non‐TB
49);
3)
control
group
64)
composed
randomly
selected
among
extrapulmonary
causes
death.
ribs,
sterna,
scapulae,
clavicles
macroscopically
observed.
New
recorded
90.5%
(76/84)
died
TB,
36.7%
(18/49)
disease
as
death,
25.0%
(16/64)
group.
These
differences
statistically
(
P
<
0.001).
Furthermore,
bony
lesions
presented
mainly
lamellar
vertebral
end
upper
middle
thoracic
rib
cage.
Proliferative
alterations
also
occurred
one
sternum
nine
eight
scapulae.
work
strongly
supports
results
similar
performed
other
documented
collections,
suggesting
that
although
not
pathognomonic,
is
useful
criterion
for
TB.
Am
J
Phys
Anthropol,
2006.
©
2005
Wiley‐Liss,
Inc.
Язык: Английский
Molecular evidence for different stages of tuberculosis in ancient bone samples from Hungary
American Journal of Physical Anthropology,
Год журнала:
2000,
Номер
113(3), С. 293 - 304
Опубликована: Янв. 1, 2000
This
paleomicrobiologic
study
was
conducted
on
osseous
tissue
specimens
from
ancient
Hungarian
skeletal
samples
the
7–8th
and
17th
centuries
AD
with
typical
macromorphologic
evidence
of
tuberculosis
(n
=
3),
morphologic
alterations
probably
due
to
6),
or
nontypical
changes
vertebral
bodies
suggestive
inflammatory
reaction
5).
From
these
bone
samples,
DNA
extracted
amplified
by
polymerase
chain
(PCR)
using
various
primer
pairs
recognizing
segments
different
mycobacterial
species.
To
confirm
specificity
analysis,
amplification
products
several
were
subjected
restriction
enzyme
digestion
and/or
direct
sequencing.
Of
analyzed
14
cases,
8
unambiguously
positive
for
Mycobacterium
complex,
as
shown
IS6110
sequence.
In
13
cases
we
found
a
PCR
product
primers
specific
65-kDa
antigen
gene,
including
2
without
genomic
DNA.
We
conclude
that
application
other
may
reveal
contamination
bones
atypical
saprophytic
mycobacteria.
A
result
mycobacteria
seen
in
3
signs
amplifiable
DNA,
6
probable
but
also
changes.
indicates
minor
reactions
surface
be
due—at
least
cases—to
infections
bacteria
M.
complex.
disease
have
proceeded
rapidly,
represent
"early"
stages
tuberculous
infection
vertebrae.
Am
J
Phys
Anthropol
113:293–304,
2000.
©
2000
Wiley-Liss,
Inc.
Язык: Английский
Using ancient DNA analysis in palaeopathology: a critical analysis of published papers, with recommendations for future work
International Journal of Osteoarchaeology,
Год журнала:
2008,
Номер
18(6), С. 600 - 613
Опубликована: Май 2, 2008
Abstract
Despite
an
observable
increase
in
the
number
of
studies
using
ancient
DNA
analysis
to
diagnose
disease
human
remains,
there
remain
issues
be
addressed
about
quality
resulting
publications.
This
paper
describes
qualitative
published
papers
that
describe
detection
pathogenic
skeletal
and
mummified
remains
from
archaeological
sites.
Its
ultimate
goal
is
provide
overview
main
problematic
relationship
standards
developed
molecular
biology
make
recommendations
for
future
work.
Sixty‐five
between
1993
2006
were
surveyed
each
was
assessed
15
criteria.
Interesting
results
emerged.
Of
particular
note
high
did
not
acknowledge
use
even
basic
contamination
control
(90%)
or
procedures
validate
independently
(85%).
study
illustrates
attention
authentication
needed
research,
if
confidence
aDNA
palaeopathology
increased.
Additionally,
methods
must
described
ensure
transparency
processes
utilised
generate
data.
Copyright
©
2008
John
Wiley
&
Sons,
Ltd.
Язык: Английский
The Categorisation of Occupation in Identified Skeletal Collections: A Source of Bias?
International Journal of Osteoarchaeology,
Год журнала:
2012,
Номер
23(2), С. 186 - 196
Опубликована: Окт. 15, 2012
ABSTRACT
Identified
skeletal
collections,
that
is,
skeletons
for
which
sex,
age
at
death
and
occupation
are
known,
have
been
used
to
test
methods
recording
entheseal
changes
(EC).
By
testing
on
identified
the
sensitivity
of
EC
activity
levels
can
be
ascertained
prior
applying
hypotheses
in
archaeological
contexts.
However,
definition
occupational
categories
this
research
may,
itself,
a
source
bias.
The
aim
study
was
how
categorising
affected
interpretation
EC.
Male
(
n
=
211)
from
two
Portuguese
collections
were
used.
Three
occupations,
all
previously
published,
each
dividing
occupations
into
five,
three
categories,
respectively.
Fibrocartilaginous
entheses
recorded
scored
as
present/absent.
Results
showed
method
frequencies
found
specific
entheses.
Frequencies
significantly
different
between
one
not
necessarily
significant
others.
This
demonstrates
categorisation
does
affect
results.
using
logistic
regression,
we
greater
effect
than
occupation.
These
results
demonstrate
need
standardised
well
importance
considering
age.
Copyright
©
2012
John
Wiley
&
Sons,
Ltd.
Язык: Английский
Investigation of the link between visceral surface rib lesions and tuberculosis in a Medieval skeletal series from England using ancient DNA
American Journal of Physical Anthropology,
Год журнала:
2002,
Номер
119(1), С. 27 - 36
Опубликована: Авг. 14, 2002
Abstract
Seven
human
skeletons
from
a
large
assemblage
rural
English
Medieval
burial
site
show
lesions,
predominantly
proliferative
in
nature,
on
the
visceral
surfaces
of
ribs.
In
order
to
investigate
whether
these
rib
lesions
were
regularly
associated
with
tuberculous
infection,
individuals,
together
group
age‐
and
sex‐matched
control
without
bony
signs
subjected
polymerase
chain
reaction
(PCR)
assays
aimed
at
detecting
traces
DNA
infecting
microorganisms
Mycobacterium
tuberculosis
complex.
The
results
provided
no
evidence
for
any
regular
association
between
surface
presence
M.
complex
study
group.
significance
findings
paleopathological
interpretation
is
discussed.
Am
J
Phys
Anthropol
119:27–36,
2002.
©
2002
Wiley‐Liss,
Inc.
Язык: Английский
Leprosy and tuberculosis in Iron Age Southeast Asia?
American Journal of Physical Anthropology,
Год журнала:
2004,
Номер
125(3), С. 239 - 256
Опубликована: Янв. 12, 2004
Abstract
The
recent
excavation
of
a
sample
120
human
skeletons
from
an
Iron
Age
site
in
the
valley
Mun
River,
tributary
Mekong
River
on
Khorat
Plateau
northeast
Thailand,
has
provided
largest
this
period
region
to
date.
This
paper
reviews
three
individuals
with
pathological
changes
for
which
differential
diagnosis
includes
systemic
infectious
disease.
In
two
these,
both
males
lesions
hands
and
feet,
leprosy
psoriatic
arthritis
are
discussed
as
diagnoses,
most
probable.
third,
female
spine,
tuberculosis
nonspecific
osteomyelitis.
Tuberculosis
is
probable
diagnosis.
Although
focus
presentation
evidence
disease
at
Noen
U‐Loke,
significance
diagnoses
mycobacterial
diseases
history
prehistory
mainland
Southeast
Asia
also
briefly
discussed.
Am
J
Phys
Anthropol,
2004.
©
2004
Wiley‐Liss,
Inc.
Язык: Английский
Genotyping of ancientMycobacterium tuberculosis strains reveals historic genetic diversity
Proceedings of the Royal Society B Biological Sciences,
Год журнала:
2014,
Номер
281(1781), С. 20133236 - 20133236
Опубликована: Фев. 26, 2014
The
evolutionary
history
of
the
Mycobacterium
tuberculosis
complex
(MTBC)
has
previously
been
studied
by
analysis
sequence
diversity
in
extant
strains,
but
not
addressed
direct
examination
strain
genotypes
archaeological
remains.
Here,
we
use
ancient
DNA
sequencing
to
type
11
single
nucleotide
polymorphisms
and
two
large
MTBC
strains
present
10
samples
from
skeletons
Britain
Europe
dating
second-nineteenth
centuries
AD.
results
enable
us
assign
groupings
lineages
recognized
MTBC.
We
show
that
at
least
during
eighteenth-nineteenth
AD,
M.
belonging
different
genetic
groups
were
same
time,
possibly
even
a
location,
evidence
for
mixed
infection
one
individual.
Our
study
shows
typing
applied
multiple
can
provide
sufficiently
detailed
information
contribute
both
knowledge
tuberculosis.
Язык: Английский
Skeletal evidence of tuberculosis in a modern identified human skeletal collection (Certosa cemetery, Bologna, Italy)
American Journal of Physical Anthropology,
Год журнала:
2015,
Номер
157(3), С. 389 - 401
Опубликована: Фев. 24, 2015
The
diagnosis
of
tuberculosis
(TB)
in
osteoarcheological
series
relies
on
the
identification
osseous
lesions
caused
by
disease.
study
identified
skeletal
collections
provides
opportunity
to
investigate
distribution
relation
this
aim
was
examine
evidence
for
TB
late
adolescent
and
adult
individuals
from
human
collection
Certosa
cemetery
Bologna
(Italy,
19th-20th
c.).
sample
group
consists
244
(138
males,
106
females)
ranging
17
88
years
age.
divided
into
three
groups
basis
recorded
cause
death:
(N
=
64),
pulmonary
non-TB
29),
other
diseases
151).
Skeletal
reported
be
related
were
analyzed.
vertebral
classified
types:
enlarged
foramina
(EnF,
vascular
with
diameter
3-5
mm),
erosions
(ER),
(OtF,
cavities
various
shapes
>
3
mm).
A
CT
scan
analysis
also
performed
bodies.
Some
seldom
present
our
(e.g.,
tuberculous
arthritis).
OtF
(23.7%)
subperiosteal
new
bone
formation
ribs
(54.2%)
are
significantly
more
frequent
respect
groups.
showed
that
vertebrae
who
have
died
may
internal
absence
external
lesions.
These
traits
represent
useful
elements
paleopathological
TB.
Язык: Английский
The association between skeletal lesions and tuberculosis diagnosis using a probabilistic approach
International Journal of Paleopathology,
Год журнала:
2019,
Номер
27, С. 88 - 100
Опубликована: Янв. 18, 2019
Язык: Английский
A Late Neolithic Case of Pott's Disease from Hungary
International Journal of Osteoarchaeology,
Год журнала:
2012,
Номер
24(6), С. 697 - 703
Опубликована: Май 28, 2012
Язык: Английский
