Celiac Disease: Beyond Diet and Food Awareness

Foods, Год журнала: 2025, Номер 14(3), С. 377 - 377

Опубликована: Янв. 24, 2025

Celiac disease is attributable to a combination of genetic predisposition and exposure dietary gluten, with immune system involvement. The incidence increasing globally, the societal economic burden celiac stretches beyond cost gluten-free food. This enteropathy that affects small intestine has been related different disorders comorbidities. Thus, implications suffering from this are multidimensional need further consideration. serious condition remains under-recognized, resulting in an increased for programs better management. review aims summarize current evidence regarding diseases, special emphasis on clinical implications, diagnosis, management, socioeconomical aspects, future perspectives.

Язык: Английский

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Association Between Type 1 Diabetes Mellitus and Celiac Disease: Autoimmune Disorders With a Shared Genetic Background

Cureus, Год журнала: 2022, Номер unknown

Опубликована: Март 7, 2022

Type 1 diabetes mellitus (T1DM) and celiac disease (CD) are one of the most recognized related autoimmune disorders as they share a common genetic background that has been found in HLA genotype, more specifically DQ2 DQ8 molecules. Studies have shown environmental factors early or late exposure to cereals first months life acquired viral infections implicated risk development autoantigens. CD, cases, is asymptomatic; therefore, it goes underdiagnosed. As result, linked consequences decreased growth, delayed puberty, anemia. Also, CD considered an independent factor for nephropathy retinopathy. Therefore, T1DM patients, high-risk individuals, screening recommended, especially analyze their joint management. A gluten-free diet studied possible benefits glycemic control decreasing hypoglycemic episodes preventing bowel mucosal damage gluten well documented primary trigger these responses. This article reviewed concurrent occurrence regarding pathogenesis, clinical overlaps, screening, management options.

Язык: Английский

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Neuropsychiatric Disorders: Bridging the Gap Between Neurology and Psychiatry

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Янв. 4, 2024

Given the ongoing difficulties faced by clinicians and researchers in dealing with neuropsychiatric illnesses, it is becoming more evident that there a need to go beyond traditional disciplinary boundaries. This research consolidates existing material, examining changes history, fundamental neurobiological aspects, shared clinical manifestations between neurology psychiatry. inquiry examines historical development of neuropsychiatry, focusing on relationship early understandings mental illness later division The focus recent advancements comprehending common pathways genetic factors highlight merging these fields. highlights complexities presentations illnesses analyzing overlapping cognitive, affective, behavioral symptoms. text critiques diagnostic issues frameworks, emphasizing limitations differentiating neurological psychiatric origins. has ramifications for achieving correct diagnosis arranging appropriate treatment. paper explores developing multidisciplinary care approaches, highlighting successful collaborations neurologists psychiatrists. study carrying out plan process identifying obstacles combining different elements. It also urgent improved instruction learning smooth cooperation. therapeutic implications investigating pharmacological therapies pathways. discusses involved managing diseases occur together. non-pharmacological therapies, such as psychotherapy rehabilitation methods, part comprehensive treatment approach. Anticipating future, report identifies areas where could be forecasts influence technological improvements subject. Suggestions are put encourage additional exploration, cooperation, originality narrow divide psychiatry, ultimately augmenting our comprehension illnesses. real-time synthesis adds discussion, providing valuable insights align ever-changing field contemporary therapy.

Язык: Английский

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Celiac disease - a pluripathological model in pediatric practice

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 23, 2024

Being defined as an autoimmune, chronic pathology, frequently encountered in any age group, but especially pediatrics, celiac disease (also called gluten enteropathy), is gaining more and ground terms of diagnosis, also interest research. The data from the literature last decades attest chameleonic way its presentation, there may be both classic onset symptoms atypical symptoms. Given impact played by disease, optimal growth development children, current narrative review aims to highlight presentation methods, intended guide clinician towards inclusion pathology differential diagnosis scheme. To these we add summary general therapeutic lines regarding underlying condition existing comorbidities. In order place related information up date, performed a recent articles published international databases. We bring forward theories approaches manifestations. Among note mainly constitutional, skin or mucous, bone, neuro-psychic, renal, reproductive injuries, disorders biological constants association with multiple autoimmunities. Knowing correlating them key management patients, thus reducing subsequent burden disease.

Язык: Английский

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Vulnerability in Children with Celiac Disease: Findings from a Scoping Review

Children, Год журнала: 2024, Номер 11(6), С. 729 - 729

Опубликована: Июнь 14, 2024

(1) Background: The scientific literature highlights that children diagnosed with celiac disease (CD) are at a heightened risk of experiencing physical, psychological, and social challenges, impacting their overall healthy childhood development. However, there remains lack clear understanding regarding the factors contribute to this vulnerability. purpose study is analyze map evidence on sociopsychosomatic vulnerability these identify gaps in topic. (2) Methods: Following Joanna Briggs Institute's guidelines for scoping reviews, we executed detailed search key electronic databases explored grey capture broad spectrum studies. Our focus was identifying research looked into multiple dimensions vulnerability-physical, social-in CD. We included diverse range designs as well systematic ensuring comprehensive analysis. selection process stringent, utilizing clearly defined inclusion exclusion criteria. (3) Results: identified 61 studies met our review highlighted significant adverse health outcomes CD elucidated various individual environmental determinants influenced vulnerabilities. It also underscored assessment tools evaluate problems population. (4) Conclusions: findings underscore critical need further deepen vulnerabilities associated children. Developing targeted will be crucial stratifying risks enhancing care strategies vulnerable

Язык: Английский

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Persistence of anemia in patients with Celiac disease despite a gluten free diet: a retrospective study

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Март 3, 2025

Язык: Английский

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Celiac Disease Genetics, Pathogenesis, and Standard Therapy for Japanese Patients

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2075 - 2075

Опубликована: Янв. 20, 2023

Celiac disease is an autoimmune primarily affecting the small intestine that caused by ingestion of gluten in genetically susceptible individuals. The development celiac based on a complex immune response to proteins. global average prevalence general population about 1%. In recent years, it has become clear not less common Asian countries than Western but often remains undiagnosed. Although number patients with Asia expected increase improving recognition and advances diagnostic techniques, there remain few reports Far East region Asia, especially Japan. this paper, we outline epidemiology, diagnosis, treatment disease. addition, summarize reported Japanese cases overview

Язык: Английский

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Celiac Disease Deep Learning Image Classification Using Convolutional Neural Networks

Journal of Imaging, Год журнала: 2024, Номер 10(8), С. 200 - 200

Опубликована: Авг. 16, 2024

Celiac disease (CD) is a gluten-sensitive immune-mediated enteropathy. This proof-of-concept study used convolutional neural network (CNN) to classify hematoxylin and eosin (H&E) CD histological images, normal small intestine control, non-specified duodenal inflammation (7294, 11,642, 5966 respectively). The trained classified with high performance (accuracy 99.7%, precision 99.6%, recall 99.3%, F1-score 99.5%, specificity 99.8%). Interestingly, when the same (already for 3 class images), analyzed adenocarcinoma (3723 new images were as in 63.65%, control 34.73%, 1.61% of cases; was retrained using 4 subtypes, above 99% 97% adenocarcinoma. Finally, model added 13,043 Crohn’s include other inflammatory bowel diseases; comparison between different CNN architectures performed, gradient-weighted activation mapping (Grad-CAM) technique understand why deep learning made its classification decisions. In conclusion, CNN-based system 5 diagnoses performance. Narrow artificial intelligence (AI) designed perform tasks that typically require human intelligence, but it operates within limited constraints task-specific.

Язык: Английский

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Allergic and immunologic evaluation of children with celiac disease

Frontiers in Pediatrics, Год журнала: 2025, Номер 13

Опубликована: Апрель 9, 2025

Celiac disease (CD) and allergic diseases are immune-mediated disorders with overlapping clinical immunologic features. The association between CD selective immunoglobulin (Ig) A deficiency (sIgAD) is well-established, but limited data exist on the relationship CD, other antibody deficiencies, in children. This study aimed to evaluate prevalence of manifestations abnormalities children CD. prospective included biopsy-confirmed followed at a gastroenterology clinic from August 2022 February 2023. Participants underwent comprehensive evaluation, including serum levels, vaccine responses, lymphocyte subgroup analysis, allergy testing as clinically indicated. cohort 76 patients median age 11 years diagnosis 5.8 years. Allergic aeroallergen sensitivity (22.4%), rhinitis (15.8%), conjunctivitis (13.2%), food (5.3%), asthma eczema (3.9% each). Immunologic evaluations revealed normal profiles 69.7% patients, while partial IgM (6.6%), unclassified hypogammaglobulinemia sIgAD (2.6%), transient infancy (2.6%). Elevated IgE levels were observed 13.2% patients. highlighted significant extending beyond commonly recognized sIgAD. These findings underscore importance evaluation

Язык: Английский

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Interleukin-15 gene polymorphism in children with celiac disease: a single-center experience

European Journal of Pediatrics, Год журнала: 2025, Номер 184(5)

Опубликована: Апрель 23, 2025

Abstract The purpose of this study is to evaluate the demographics, clinical presentation, laboratory findings, and gastrointestinal endoscopic findings in children with CD assess their relationship interleukin-15 (IL-15) single-nucleotide polymorphism (SNP) (rs2857261) serum IL-15 levels. This case–control prospective cohort included 54 newly diagnosed pediatric patients attending Gastroenterology Clinic at Alexandria University Children’s Hospital 44 age- sex-matched healthy controls. Demographics, data, tests, Marsh classification, SNP genotypes were analyzed. Follow-up after 9 months on a gluten-free diet (GFD) was conducted. mean age controls 8.62 ± 4.4 8.07 4.7 years, respectively, no significant difference ( p = 0.55). Male representation 48.1% 47.7% 0.97). most common presenting symptoms abdominal distension (61.11%) failure thrive (59.26%). Laboratory showed that anti-tissue transglutaminase immunoglobulin A 103 168 U/ml, anti-endomysium positive 51.85% patients. Histopathological assessment revealed 3C as finding (37%), while 37% without biopsy. analysis significantly higher prevalence A/A genotype compared < 0.0001). A/G G/G protective against CD, odds ratios 0.088 0.079, respectively. No associations observed between clinical, laboratory, or histological variables. After 6 GFD, did not influence symptom resolution > 0.05). Conclusions : Serum levels are elevated associated increased susceptibility appear protective. These highlight potential biomarker therapeutic target CD. Further large-scale studies warranted validate these explore applications. What Known: • Celiac disease an immune-mediated enteropathy linked HLA-DQ2/DQ8 alleles, playing key role its pathogenesis. Variability genetic polymorphisms has been suggested but remains underexplored populations. New: identifies risk factor for Elevated target.

Язык: Английский

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