Veterinary Sciences, Год журнала: 2024, Номер 11(10), С. 480 - 480
Опубликована: Окт. 7, 2024
Equine colitis is a devastating disease with high mortality rate. Infectious pathogens associated in the adult horse include
Язык: Английский
Balkan Medical Journal, Год журнала: 2024, Номер unknown, С. 7 - 22
Опубликована: Янв. 3, 2024
Heartfailure, ischemic myocardial injuries, microvascular disease, Kounis syndrome, prolonged COVID, fibrosis, myocarditis, new-onset hypertension, pericarditis, postural orthostatic tachycardia pulmonary stroke, Takotsubo venous thromboembolism, and thrombocytopenia.In this narrative review, we describe elucidate when, where, how COVID-19 affects the human cardiovascular system in various parts of body that are vulnerable every patient category, including children athletes.
Язык: Английский
Процитировано
10
npj Science of Food, Год журнала: 2024, Номер 8(1)
Опубликована: Март 30, 2024
Язык: Английский
Процитировано
9
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Март 14, 2025
Abstract Background Infection with SARS-CoV-2, the virus responsible for COVID-19, can lead to a range of physical symptoms and mental health challenges, including stress, anxiety, depression. These effects are particularly pronounced in hospitalized patients, likely due virus’s direct indirect impact on nervous system. Gut dysbiosis, an imbalance gut microbiome, has been implicated immune dysfunction chronic inflammation COVID-19 patients. However, interactions between microbiome composition remain incompletely understood. Methods We investigated association symptoms, cytokine profiles, microbiota 124 collected data demographics, severity, indicators (stress, depression). profiling was performed using full-length 16 S rRNA gene sequencing evaluate microbial diversity composition. Results severity categorized as low (27.4%), moderate (29.8%), or critical (42.8%). Common included fever (66.1%) cough (55.6%), while somatic (27.3%), anxiety depressive (39%), stress (80.5%) were frequently self-reported. Elevated interleukin-6 levels severe cases highlighted systemic inflammation, reduced bacterial diversity, among women obese correlated higher disease severity. Notably, genus Mitsuokella associated increased distress, Granulicatella linked illness. Conclusions Our findings reveal significant associations status, dysbiosis results indicate potential microbiome-targeted therapies mitigate psychological complications improve recovery outcomes this population.
Язык: Английский
Процитировано
1
PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0313068 - e0313068
Опубликована: Фев. 10, 2025
SARS-CoV-2 can infect different organs, including the intestine. In an in vitro model of Caco-2 intestinal cell line, we previously found that modulates ACE2 receptor expression and affects molecules involved intercellular junctions. To further explore possibility epithelium serve as alternative infection route for SARS-CoV-2, used a polarized monolayers cells (or co-cultures two lines: HT29) grown on polycarbonate membrane Transwell inserts, inoculated with virus either upper or lower chamber culture to determine tropism apical basolateral pole these cells. both co-culture Caco-2/HT29 monolayer, inoculation was be much more effective establishing than inoculation. addition, triggers monolayer degeneration, shown by histological examination, measurement trans-epithelial electrical resistance, adhesion molecule expression. During infection, infectious viruses reach chamber, suggesting transcytosis mechanism from side cells, paracellular trafficking after damage junctions epithelial barrier, both. Taken together, data indicate preferential human tract suggest via lumen leads systemic infection.
Язык: Английский
Процитировано
0
Environmental Toxicology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
ABSTRACT Microplastics (MPs) have emerged as novel environmental pollutant. Their ubiquity in natural environments and the global dissemination of plastic particles through food drink led to oral ingestion these by all kinds living organism. In this investigation, male mice were subjected exposure 2 μm virgin PS‐MPs for 6 weeks. To accomplish this, 36 adult NMRI gavaged with at concentrations 0.01, 0.1, 1 mg/kg body weight. A control group was also accounted for, which received 0.1 mL distilled water. The results show that activity antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase) decreased, while level malondialdehyde increased colon liver. Additionally, findings showed can disrupt integrity intestinal barrier inhibit secretion mucus mice, mucin secretion, cause changes tissue structure Further information regarding toxicity MPs a terrestrial organism obtained study, assist evaluation potential health hazards may pose organisms.
Язык: Английский
Процитировано
0
Archives of Gerontology and Geriatrics Plus, Год журнала: 2025, Номер unknown, С. 100142 - 100142
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Virology Journal, Год журнала: 2025, Номер 22(1)
Опубликована: Март 21, 2025
SARS-CoV-2 infection has been responsible of COrona VIrus Disease (COVID-19) pandemia and can cause a variety symptoms including gastrointestinal disorders, abdominal pain liver injury. The host receptor for SARS-CoV-2, ACE2, is expressed in gut could induce vascular damage immune system dysregulation, creating an inflammatory hypercoagulable state, as widely described at the lung level. This work presents case middle-aged Caucasian man admitted to Hospital Emergency Department from University Ferrara (Italy), complaining upper middle region abdomen. patient tested negative nose-oropharyngeal swab four weeks after recovering viral infection. required resection segment ileum ulcer bowel wall was recognized sampled. Previous published results had confirmed presence nucleocapsid protein, increased human leukocyte antigen (HLA-G) altered morphology microvilli ulcerated when compared non-ulcerated ileum. present study sought deepen consequences To this end, we evaluated expression co-expression Vascular Endothelial Growth Factor (VEGF) Fibronectin by immunohistochemical techniques. VEGF higher than control sample areas co-expressed with SPIKE protein. staining lower Electron microscopy analysis showed alterations integrity intestinal barrier area or sample. Although protein detected his terminal ileum, especially areas. also associated increase Fibronectin. In addition changes, junctional apparatus among epithelial cells, making tissue even more fragile thus susceptible entry pathogens development further infections.
Язык: Английский
Процитировано
0
Digestive Diseases and Sciences, Год журнала: 2025, Номер unknown
Опубликована: Май 2, 2025
Язык: Английский
Процитировано
0
OBM Neurobiology, Год журнала: 2025, Номер 09(02), С. 1 - 17
Опубликована: Май 9, 2025
The COVID-19 pandemic was an eye-opener for many medical disciplines. It highlighted viral exploitation of physiological cellular processes, including endocytosis and senescence. These pathways play essential role in cancer, neurodegenerative disorders, schizophrenia (SCZ). Oxytocin, commonly called the “love hormone,” is produced posterior hypothalamus crucial various social intelligence, sexual activity, metabolism. Many viruses, SARS-CoV-2, have been shown to inhibit release oxytocin from intestinal epithelial cells, thus hastening gut barrier Premature molecular aging at this level enables microbial migration outside lumen, triggering inflammation immunogenicity. community immunologically tolerated within gastrointestinal tract but can activate host immunity upon translocation. Immune responses displaced commensals and/or their components may contribute neuroinflammation gray matter volume reduction, a hallmark severe mental illness. Oxytocin opposes translocation into systemic circulation through several mechanisms, anti-inflammatory, tight junctions-upregulation, suppression senescence-associated secretory phenotype—the toxic secretome by senescent cells. <em>Limosilactobacillus reuterii, </em>a commensal microbe known producing oxytocin, shows antiviral anti-translocation effects, implying beneficial schizophrenia. This condition has linked dysfunctional increased suggesting that replacement therapy could benefit patients with review article summarizes current understanding oxytocin's discusses natural synthetic compounds promote homeostasis.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Май 14, 2025
Background The COVID-19 pandemic has had a significant impact on public health. However, the of infection during pregnancy microbiome mother and her newborn child still remains poorly understood. Methods This study involved 94 mother-child pairs whose mothers 44 newborns as control group recruited in 2018. Stool samples were collected from women before delivery infants at 5–7 days after birth used for 16S rRNA sequencing. Results We found that microbiomes exposed utero to showed decreased microbial diversity richness. Moreover, we observed higher inter-sample variability between infant case group, which might suggest destabilization their microbiomes. Neither alpha- nor beta-diversity metrics differed significantly groups depending trimester when contracted COVID-19. Thus, timing prenatal exposure no effect gut microbiome. Conclusion can compromise establishment presumably by disrupting mother’s
Язык: Английский
Процитировано
0