International Journal of Biomedicine,
Год журнала:
2023,
Номер
13(4)
Опубликована: Дек. 5, 2023
Background:
This
study
aimed
to
estimate
the
levels
of
C-reactive
protein
(CRP)
and
prolactin
(PRL)
in
SARS-CoV2
infection
their
association
with
severity
COVID-19
among
patients
Ajman,
UAE.Methods
Results:
cross-sectional
was
conducted
Thumbay
Hospital
from
2020
2021.The
included
71
(55
males
16
females)
positive
SARS-CoV-2
test
results.Nasal
swab
specimens
were
collected
for
on
day
admission
or
after
one
admission.COVID-19
diagnoses
determined
according
New
Coronavirus
Pneumonia
Prevention
Control
Program
(7th
edition)
published
by
National
Health
Commission
China
(2020).Serum
samples
upon
admission.The
PRL
level
using
immune
chemiluminescent
method
DXI
800
Beckman
Coulter
analyzer.The
CRP
immunoturbidimetric
DXC
700
AU
chemistry
analyzer.Among
patients,
great
majority
men
55(77.5%),38(53.5%)being
Indian
nationality.In
this
study,
most
participants
(50.7%)
had
no
history
chronic
illnesses.In
terms
severity,
24(33.8%)
mild
cases,
27(38.0%)had
moderate
20(28.2%)had
severe
cases.Twenty
(28.2%)
transferred
ICU,
19(26.8%)were
intubated.The
patients'
average
age
47.58±13.63,CRP
-74.30±71.46mg/L,
-205.1946±168.52ng/mL.The
mean
highest
compared
a
statistically
significant
difference
between
groups
(P=0.000)
(P=0.004).The
cases
cases;
however,
differences
not
significant.CRP
greater
ICU
than
non-ICU
only
CRP.We
found
correlation
(r=0.458,P=0.000);
weak
(r=0.201,P=0.093).A
(r=0.461,P=0.03)
significant.
Conclusion:The
current
implies
that
serum
might
be
an
important
indication
development
severity.A
more
extensive
larger
sample
size
is
needed
validate
significance
disease
severity.
Endocrine,
Год журнала:
2024,
Номер
85(1), С. 44 - 66
Опубликована: Фев. 12, 2024
Studies
investigating
the
effects
of
SARS-CoV-2
on
male
reproductive
function
are
few
and
heterogeneous,
results
often
conflicting.
This
systematic
review
meta-analysis
was
carried
out
studies
conducted
in
men
with
active
or
anamnestic
infection
to
evaluate
its
consequences
sex
hormone
profile
semen
parameters.
Abstract
Background
The
Corona
Virus
Disease
2019
(COVID-19)
pandemic
has
raised
concerns
regarding
its
potential
impact
on
male
reproductive
health.
However,
the
of
COVID-19
sperm
quality
remains
uncertain.
This
retrospective
study
aimed
to
investigate
short-term
and
relatively
long-term
effects
infection
quality.
Methods
A
total
85
males
with
fertility
requirements,
who
underwent
semen
evaluation
at
Guilin
People’s
Hospital
between
June
2022
July
2023,
were
included
in
study.
Changes
parameters
analyzed
across
three
specific
timeframes:
within
6
months
before
infection,
3
after
3–6
recovery.
Results
results
revealed
that
concentration
number
significantly
lower
compared
before,
while
recovery
period,
concentration,
count,
progressive
motility,
normal
morphology
increased.
Comparing
periods,
most
significant
difference
was
observed
which
exhibited
a
decrease
but
returned
levels
from
COVID-19.
Conclusions
These
findings
suggest
may
exert
some
quality,
particularly
evidenced
by
decreased
post-infection.
Fortunately,
these
appear
be
temporary,
gradual
restoration
further
research
is
needed
explore
underlying
mechanisms
implications
changes
parameters.
Reproductive Medicine and Biology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 1, 2025
Abstract
Background
As
the
COVID‐19
pandemic
nears
resolution
in
2024,
mechanisms
by
which
SARS‐CoV‐2
and
other
viral
infections
induce
spermatogenic
dysfunction
remain
poorly
understood.
This
review
examines
infections,
particularly
COVID‐19,
disrupt
spermatogenesis
highlights
implications
for
male
reproductive
health.
While
reports
suggest
that
caused
is
mild
transient,
these
findings
may
have
broader
applications
understanding
treating
future
infections.
Methods
The
PubMed
database
was
searched
to
identify
original
articles
investigating
SARS‐CoV‐2,
contribute
dysfunction.
Main
Findings
affects
testis
through
multiple
mechanisms,
including
ACE2
receptor‐mediated
entry,
direct
damage,
inflammatory
response,
blood–testis
barrier
disruption,
hormonal
imbalance,
oxidative
stress,
impaired
spermatogenesis.
combination
of
factors
can
testicular
function
complexity
effects
on
Conclusion
infection,
systemic
inflammation,
stress.
Ongoing
research,
vaccination
efforts,
clinical
vigilance
are
essential
address
challenges
develop
effective
treatment
prevention
strategies.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Апрель 3, 2025
To
ascertain
whether
COVID-19
infection
affects
sperm
quality
and
measure
the
scale
of
effects.
A
cross
sectional
study
a
longitudinal
were
conducted
during
SARS-CoV-2
pandemic
(from
September
7th
2022
to
late
January
2023)
in
China.
604
patients
participated
study;
140
with
149
unaffected
natural
controls.
The
included
participants
who
produce
semen
sample
after
COVID-19.
positive
could
provide
samples
before
infection.
In
addition,
by
two
consecutive
over
same
period
as
controls
for
study.
Conventional
parameters
including
count,
motility,
morphology
more
recent
such
DNA
fragmentation
index
(DFI)
chromatin
immaturity
observed.
study,
exposure
group
demonstrated
significantly
lower
total
count
(159.58
×
106
vs.
185.42
106,
P
=
0.042),
percentage
grade
sperms
(5.37%
8.45%,
0.009),
progressive
motility
(24.74
±
14.96%
28.73
16.65%,
0.023),
(32.04
18.03%
36.91
20.86%,
0.022),
higher
DFI
(17.50%
11.75%,
0.030)
than
infection,
showed
(131.80
173.63
Δd
-20.49
0.018
),
(
2.61%
8.50%,
-3.18%,
<
0.001),
(19.82
13.68%
24.88
14.97%,
-5.07
11.94%,
0.001)
(26.64
17.35%
32.25
18.69%,
-5.62
14.30%,
(32.10
21.30%
26.49
18.54%,
5.61
13.71%,
0.039)
while
negative
opposite
changes.
Finally,
59.29%
deteriorated
concentration,
57.86%
71.43%
Grade
sperm,
65.00%
69.29%
75.00%
DFI,
changes
all
less
40%
(P
0.002).
was
associated
poor
quality.
findings
would
be
useful
clinicians
manage
men
fertility
problems
suffered
Translational Andrology and Urology,
Год журнала:
2024,
Номер
13(9), С. 1835 - 1846
Опубликована: Сен. 1, 2024
As
the
Omicron
variant
became
dominant
coronavirus
disease
2019
(COVID-19)
strain
and
threat
to
human
health
decreased,
impact
of
COVID-19
on
male
reproductive
semen
quality
may
have
changed.
In
this
prospective
observational
study,
we
aimed
investigate
changes
in
sexual
function
before
after
infection
by
self-controlled
study
explore
influence
health.
Evidence
indicates
a
wide
range
of
andrological
alterations
in
patients
with
the
Severe
Acute
Respiratory
Syndrome
CoronaVirus
2
(SARS-CoV-2)
infection
and
Coronavirus
Disease
2019
(COVID-19).
Andrology,
Год журнала:
2023,
Номер
12(5), С. 1078 - 1095
Опубликована: Окт. 24, 2023
Abstract
Background
The
implications
of
SARS‐CoV‐2
infection
on
male
fertility
remain
largely
unknown.
Besides
their
well‐known
pro‐
and
anti‐inflammatory
actions,
prostaglandins
polyamines
are
present
in
semen,
where
they
play
key
roles
sperm
quality.
Objectives
To
analyze
semen
parameters,
oxidative
profile
the
seminal
fluid
prostaglandin
polyamine
systems
samples
collected
from
individuals
without
coronavirus
disease
2019
diagnosis
men
who
recovered
2019.
Materials
methods
This
study
compared
positive
with
obtained
1–6
months
7–30
post
infection.
Semen
thiobarbituric
acid
reactive
substances,
cyclooxygenase
2
expression
by
fluorescence
immunocytochemistry
immunoblotting,
levels
enzyme
immunoassay,
ornithine
decarboxylase
activity
a
radioactive
assay,
acetylated
thin‐layer
chromatography
were
assessed.
Results
In
both
groups
men,
vitality,
total
progressive
motility,
putrescine
significantly
decreased
when
uninfected
group.
contrast,
lipid
peroxidation,
leukocyte‐associated
expression,
D2
higher
than
individuals.
While
concentration
morphology,
activity,
N‐acetylputrescine
statistically
diminished
up
to
6
after
recovery,
these
parameters
remained
unchanged
recovery.
Coronavirus
vaccination
did
not
show
negative
effects
any
evaluated.
Discussion
conclusion
Our
work
provides
insights
into
detrimental
impact
several
some
cases,
even
more
year
infection,
which
would
be
accompanied
alterations
profiles.
Therefore,
future
treatments
targeting
pathways
could
lead
successful
reinstatement
parameters.
