Chronic exposure to E-cigarette aerosols potentiates atherosclerosis in a sex-dependent manner

Toxicology and Applied Pharmacology, Год журнала: 2024, Номер 492, С. 117095 - 117095

Опубликована: Сен. 6, 2024

Язык: Английский

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Mulberroside A attenuates cigarette smoke-induced atherosclerosis in ApoE−/− mice via the Sirt1-HIF-1α axis

Cellular Signalling, Год журнала: 2024, Номер unknown, С. 111400 - 111400

Опубликована: Сен. 1, 2024

Язык: Английский

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Vascular Stress Markers Following Inhalation of Heated Tobacco Products: A Study on Extracellular Vesicles

Cardiovascular Toxicology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract The advent of heated tobacco products (HTPs) has introduced new variables in the study nicotine delivery systems and their health implications. Amidst concerns over cardiovascular effects, this aims to elucidate acute impact HTP inhalation on extracellular vesicles (EV) levels young, healthy individuals. In controlled, exposure study, 23 volunteers were subjected inhalation. EV endothelial platelet origin quantified through flow cytometry before after exposure. Data analysis was performed using multiple measures ANOVA assess changes concentrations. Our findings reveal a significant increase EVs following short-term with nicotine. Notably, no change observed leukocyte- neutrophil-derived EVs. This suggests vascular stress, peak 4 h post-exposure. rise platelet-derived aligns documented responses injury, paralleling effects seen traditional cigarette e-cigarette use. Despite HTPs being marketed as safer alternatives, our results indicate that nicotine-containing may still pose risks. These contribute growing body evidence cautioning against perceived safety reinforce importance regulatory oversight public initiatives targeting technologies. Trial Registrations: ClinicalTrials.gov ID: NCT04824495, registered 2021–01-07.

Язык: Английский

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Functional Foods in Preventing Human Blood Platelet Hyperactivity-Mediated Diseases—An Updated Review

Nutrients, Год журнала: 2024, Номер 16(21), С. 3717 - 3717

Опубликована: Окт. 30, 2024

Backgrounds/Objectives: Abnormal platelet functions are associated with human morbidity and mortality. Platelets have emerged as critical regulators of numerous physiological pathological processes beyond their established roles in hemostasis thrombosis. Maintaining function is essential to preventing platelet-associated diseases such cardiovascular disease, cancer metastasis, immune disorders, hypertension, diabetes, sickle cell inflammatory bowel sepsis, rheumatoid arthritis, myeloproliferative Alzheimer's disease. become hyperactive obesity, a sedentary lifestyle, pollution, smokers. Platelets, upon activation, can trawl leukocytes progenitor cells the vascular sites. release various proinflammatory, anti-inflammatory, angiogenic factors shed microparticles circulation, thus promoting reactions. These platelet-released also maintain sustained further impacting these disease processes. Although mechanisms unknown, multiple stimuli induce hyperreactivity but involve early pathways activation. The exact how platelets contribute still unclear, antiplatelet strategies inevitable for diseases. Reducing during stages could significantly impact However, while this potentially worthwhile intervention, using drugs limit apparently healthy individuals without not recommended due increased risk internal bleeding, resistance, other side effects. challenge therapeutic intervention identifying that preferentially block specific targets involved platelets' complex contribution leaving hemostatic at least partially intact. Since aspirin primary preventives, it use alternative safe inhibitors

Язык: Английский

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Atherosclerosis: Progression, risk factors, diagnosis, treatment, probiotics and synbiotics as a new prophylactic hope

The Microbe, Год журнала: 2024, Номер 5, С. 100212 - 100212

Опубликована: Ноя. 28, 2024

Язык: Английский

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