Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(12)
Опубликована: Дек. 25, 2024
With
advances
in
therapies
to
reduce
cardiovascular
events
and
improvements
coronary
imaging,
an
increasing
number
of
clinical
trials
have
demonstrated
that
treatments
artery
disease
are
associated
with
favorable
effects
on
atherosclerotic
plaque
size
characteristics.
It
has
been
observed
various
drugs
may
induce
regression
enhance
stability
after
formation.
Numerous
conducted
verify
the
occurrence
stabilization
their
beneficial
events.
Using
invasive
imaging
techniques
such
as
intravascular
ultrasound
(IVUS)
optical
coherence
tomography
(OCT),
researchers
able
gather
evidence
supporting
existence
regression.
In
this
review,
we
explore
possible
mechanisms
regression,
summarize
features
assemble
from
studies
used
different
observational
endpoints.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Май 30, 2025
Introduction
Atherosclerosis
(AS),
a
prevalent
cardiovascular
condition
characterized
by
cholesterol
accumulation,
inflammation,
and
fibrous
tissue
proliferation
within
arterial
walls,
remains
major
global
health
challenge.
Traditional
Chinese
Medicine
(TCM)
identifies
earthworm
(Lumbricus)
as
an
effective
treatment
for
blood
stasis
syndromes.
Some
studies
have
identified
lumbricus-derived
extracts
being
rich
in
collagenase
fibrinolytic
enzymes,
which
has
significant
effects
dissolving
clots,
improving
circulation,
preventing
thrombosis.
Therefore,
the
present
study,
novel
formulation,
fast
tablets
of
lumbricus
protein
(abbreviated
as:
LP-FDT),
was
developed
part
upcoming
new
drug
research
development,
we
used
multi-modal
ultrasonic
technique
combined
with
routine
biochemical
histopathological
analysis
methods
to
evaluate
its
efficacy
on
AS.
By
leveraging
advantages
LP-FDT
adhering
principle
3Rs
(replacement,
reduction,
refinement),
this
offers
sustainable
therapeutic
strategy
managing
The
findings
from
study
are
expected
provide
valuable
insights
into
development
patient-friendly
treatments
AS,
bridging
gap
between
traditional
therapies
modern
pharmaceutical
innovations.
Methods
Animal
model
established
ApoE-/-
feeding
high-fat
diet
8
weeks.
Multimodal
ultrasound,
along
analyses,
employed
assess
effects.
Results
significantly
reduced
plaque
size
inflammation
while
enhancing
collagen
remodeling
plaques.
Although
no
substantial
impact
serum
lipid
profiles
observed,
downregulated
MMP-2
MMP-9
expression,
suggesting
immunomodulatory
mechanism
extracellular
matrix
degradation
stabilization.
Discussion
In
confirmed
AS
multimodal
analyses.
At
same
time,
principles
minimized
animal
use
suffering
maximizing
experimental
reliability.
indicate
that
LP-FDT,
innovative
formulation
combining
TCM
technologies,
holds
promise
prevention
providing
pathway
integration
contemporary
approaches
health.
Further
investigation
molecular
mechanisms
is
warranted.
Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(12)
Опубликована: Дек. 25, 2024
With
advances
in
therapies
to
reduce
cardiovascular
events
and
improvements
coronary
imaging,
an
increasing
number
of
clinical
trials
have
demonstrated
that
treatments
artery
disease
are
associated
with
favorable
effects
on
atherosclerotic
plaque
size
characteristics.
It
has
been
observed
various
drugs
may
induce
regression
enhance
stability
after
formation.
Numerous
conducted
verify
the
occurrence
stabilization
their
beneficial
events.
Using
invasive
imaging
techniques
such
as
intravascular
ultrasound
(IVUS)
optical
coherence
tomography
(OCT),
researchers
able
gather
evidence
supporting
existence
regression.
In
this
review,
we
explore
possible
mechanisms
regression,
summarize
features
assemble
from
studies
used
different
observational
endpoints.
