Diabetic Retinopathy: Current Understanding, Mechanisms and Treatment Strategies
Mohd Amjad,
Harsh K. Gupta,
Anamika Anamika
и другие.
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(2), С. 252 - 260
Опубликована: Май 25, 2024
Researchers
have
been
assuming
about
the
possible
connection
between
eye
and
central
nervous
system
(CNS)
for
a
considerable
amount
of
time.
This
is
primarily
due
to
fact
that
considered
be
an
extension
brain,
which
reasonable
assumption.
The
neural
tube
beginning
both
structures,
neurons
are
building
blocks
structures.
Retinal
ganglionic
cells,
also
known
as
RGCs,
specific
type
cell
found
in
retina.
These
cells
responsible
receiving
light
signals
from
environment
around
them
then
transmitting
photoreceptors,
involved
process
vision.
retina,
inside
eye,
converting
into
electrical
impulses,
sent
brain
through
optic
nerve.
Glaucoma,
age-related
macular
degeneration
(AMD),
diabetic
retinopathy
only
few
illnesses
can
caused
by
chronic
progressive
neurodegeneration
more
prevalent
older
people.
It
elderly
who
most
likely
affected
these
disorders;
nevertheless,
younger
people
susceptible
may
experience
permanent
vision
loss
or
reduction
their
eyesight.
In
cases,
neurodegenerative
disorders
characteristic
CSN
characterised
common
symptoms
cause
partially
understood.
Although
certain
risk
factors
identified,
they
do
not
account
all
instances.
On
other
hand,
according
number
studies,
several
(CNS),
such
Alzheimer's
disease
(AD)
Parkinson's
(PD),
significant
mortality
morbidity
on
global
scale,
display
distinctive
alterations
at
ocular
level.
helpful
aware
potential
linkages
order
better
understanding
mechanics
onset
occurs.
addition,
experts
yet
reached
consensus
regarding
various
disorders.
this
overview,
discussed
detail,
with
particular
focus
interaction
eye.
At
some
point
future,
in-depth
could
assistance
development
innovative
treatments
help
reduce
prevent
blindness
improve
quality
life.
Язык: Английский
Therapeutic Approaches of Nutraceuticals in Neurological Disorders: A Review
Vipul Kumar,
Harsh K. Gupta,
Anamika Anamika
и другие.
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(2), С. 261 - 281
Опубликована: Май 25, 2024
A
big
problem
in
healthcare
around
the
world
is
neurological
illnesses.
There
a
huge
and
financial
burden
on
society
worldwide
due
to
dramatically
increased
risk
of
chronic
sickness
diseases
linked
with
posed
lifestyle
changes.
Fine
treatment
for
sick
illnesses
few
known
adverse
effects
goal
research.
number
functional
food
studies
have
been
launched
last
decades
an
effort
identify
meals
enhanced
therapeutic
activity
reduced
effects.
As
result,
research
into
nutraceutical
therapy
illness
prevention
various
extraction
procedures
disorders
has
underway.
Progressive
memory
loss
characterises
Alzheimer's
disease
(AD),
neurodegenerative
disorder.
The
pharmaceutical
options
available
today
are
expensive,
come
unwanted
side
effects,
short
supply.
Scientists
researchers
noticed
that
nutraceuticals
impact.
anti-Alzheimer's
efficacy
was
examined
clinical
preclinical
investigations.
study
new
targets,
such
as
pathophysiological
mechanisms
unique
cascades,
resulted
from
growing
understanding
AD
pathogenesis.
Therefore,
most
effective
well-known
will
be
showcased
present
development,
together
brief
involving
antioxidants,
autophagy
control,
anti-inflammatory,
mitochondrial
homeostasis,
more.
Nutraceuticals
real-world
impacts,
getting
your
hands
phytochemicals
other
vital
bioactive
ingredients
therapeutically
active
foods
top
priority.
Because
this,
term
"functional
foods"
muddied
replaced
similar
ones
"pharmafoods,"
"medifoods,"
"vita
foods,"
or
"medicinal
foods."
high
demand
counteract
interventions,
there
urgent
need
stick
healthy
options.
may
play
preventative
role
therapies
demonstrated
correlation
between
dietary
patterns
factors
neurodegeneration.
Examining
high-quality
trials
focus
study,
which
touches
several
important
topics.
In
light
nutraceuticals'
promise
multi-targeted
disease,
it
critical
assess
them
promising
lead
molecules
development
drugs.
Prospective
should,
according
authors'
understanding,
take
account
blood-brain
barrier
permeability
alteration,
bioavailability,
features
randomised
trials.
Язык: Английский
Role of Essential Oil Used Pharmaceutical Cosmetic Product
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(3), С. 147 - 157
Опубликована: Июнь 19, 2023
When
it
comes
to
choosing
which
cosmetics
buy,
consumers
typically
identify
the
smell
as
factor
that
is
most
important
them.
uncovered,
fatty
acids,
oils,
and
surfactants
are
frequently
included
in
cosmetic
formulations
can
all
contribute
production
of
odours
unpleasant.
Essential
oils
used
a
wide
variety
products
because,
addition
fragrant
contributions
they
make,
serve
preservatives,
active
agents,
additions
helpful
skin.
In
addition,
growing
demand
for
natural
components
has
significantly
contributed
revival
interest
plant
derivatives,
particularly
essential
industries
health.
Popular
companies
have
been
forced
promote
fragrances
pick
minimally
processed
materials
result
potential
health
concerns
related
with
artificial
compounds,
major
cosmetics.
As
this
pressure,
industry
whole
moved
towards
fragrances.
Some
highly
regarded
utilised
creation
include
citrus,
lavender,
eucalyptus,
tea
tree,
other
flower
oils.
prized
scent
various
linalool,
geraniol,
limonene,
citronellol,
citral.
fields
cosmeceuticals,
applications,
including
use
source
The
purpose
review
was
shed
light
on
those
applications.
Origins
commercial
viability
chemical
makeup
fragrance
classification,
olfactory
character
authenticity,
safety
will
receive
attention
deserve.
Язык: Английский
Clinical Features Present, Past & Future Prospective of Monkey Pox: A Orthopoxvirus
Siddhartha Shukla,
Naveen Rawat,
Sarthak Rana
и другие.
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(3), С. 134 - 146
Опубликована: Июнь 21, 2023
Some
issues
regarding
the
potential
spread
of
monkeypox
have
arisen
just
as
international
world
is
beginning
to
recover
from
initial
alarm
that
was
caused
by
probable
coronavirus
disease
2019
(COVID-19).
Despite
fact
parts
Africa
traditionally
been
more
susceptible
than
other
regions
world,
majority
new
cases
linked
outbreak
began
in
2022
reported
countries
located
Europe
and
western
hemisphere.
a
great
number
organisations
are
working
on
contact-tracing
activities
at
moment,
origin
this
still
unknown
time.
The
virus
belongs
family
viruses
known
Poxviridae
genus
Orthopoxvirus.
Following
eradication
smallpox
across
globe
1970s,
news
widespread
worry
globe.
Through
vaccination
with
virus,
individuals
were
able
develop
cross-immunity
against
monkeypox.
After
distribution
vaccine
discontinued,
outbreaks
rose.
epidemic
occurred
United
States
2003
first
time
gained
extensive
notice
media.
In
spite
its
name,
not
transmitted
monkeys.
Although
different
kinds
rodents
small
mammals
suggested
primal
hosts
virus's
true
lineage
mystery.
causes
identified
macaque
monkeys,
which
where
seen.
When
does
transfer
one
person
another,
it
often
so
through
person's
mucocutaneous
lesions
or
respiratory
droplets
they
expel.
However,
only
happens
very
infrequently.
supporting
therapy
can
be
given
reduce
symptoms,
medications
such
tecovirimat
may
administered
really
severe
cases.
At
time,
there
no
specific
treatment
for
patients
who
infected
virus;
however,
supportive
treatments
given.
It
debatable
whether
these
successful
reducing
symptoms
because
concrete
guidelines
follow
regard.
Язык: Английский
Recent Advancement in Ocular Drug Delivery System: A Systematic Review
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(3), С. 238 - 249
Опубликована: Июль 10, 2023
Recent
scientific
and
technological
advancements
have
made
ophthalmology
a
top
priority
for
the
study
of
therapeutic
products,
including
creation,
preclinical
testing,
clinical
evaluation
novel
medications,
medical
devices,
drug-medical
device
combinations.
In
order
to
decrease
metabolism
elimination
increase
residence
time
in
ocular
tissues
compartments,
sustained-release
drug
delivery
systems
such
as
liposomes,
micelles,
nano-emulsions,
nanoparticles
with
colloidal
structures,
intraocular
implants
been
developed.
Research
is
also
being
conducted
area
cutting-edge
medicines,
those
based
on
gene
or
cell
systems,
both
which
are
considered
high-risk
products
because
their
intricate
structures.
Regarding
definition
(medicinal
product)
recent
changes
regulation,
this
article
reviews
ophthalmic
drug,
gene,
cellular
related
goods
well
breakthroughs
advanced
medicinal
Products.
Язык: Английский
Recent Approaches of Intranasal to Brain Drug Delivery System
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(3), С. 173 - 182
Опубликована: Июнь 30, 2023
While
the
intranasal
administration
of
drugs
to
brain
has
been
gaining
both
research
attention
and
regulatory
success
over
past
several
years,
key
fundamental
translational
challenges
remain
fully
leveraging
promise
this
drug
delivery
pathway
for
improving
treatment
various
neurological
psychiatric
illnesses.
In
response,
review
highlights
current
state
understanding
nose-to-brain
how
biological
clinical
barriers
transport
using
can
addressed,
as
illustrated
by
demonstrations
currently
approved
sprays
leverage
these
pathways
enable
design
successful
therapies.
Moving
forward,
aiming
better
exploit
pathway,
we
also
outline
development
nanoparticle
systems
that
show
improvement
in
delivering
engineered
formulations
could
aid
breakthroughs
terms
emerging
therapeutics
while
avoiding
systemic
adverse
effects.
Язык: Английский
Plant & its Bioactive Components Uses in Cardio-Potential Diseases: A Sectional Study for Different Herbs
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2023,
Номер
2(5), С. 61 - 71
Опубликована: Окт. 25, 2023
Thirty
percent
of
all
deaths
that
occur
each
year
can
be
attributed
to
heart
disease,
stroke,
and
other
forms
cardiovascular
disease.
The
World
Health
Organisation
(WHO)
predicts
by
the
2030,
annual
death
toll
from
diseases
will
have
increased
22.2
million,
up
present
total
17.9
million.
Mortality
rates
tend
go
in
populations
as
they
get
older.
chance
dying
disease
is
significantly
higher
for
females
(51%)
than
it
males
(42%).
majority
people
treat
prevent
using
plant-based
medications
(also
known
phytochemicals),
either
addition
or
instead
pharmaceuticals
are
readily
available
on
market.
In
this
study,
efficacy
treating
illness
evaluated
92
different
plants,
including
15
terrestrial
plants.
A
number
medicinal
herbs,
Daucus
carota,
Nerium
oleander,
Amaranthus
Viridis,
Ginkgo
biloba,
Terminalia
arjuna,
Picrorhiza
kurroa,
Salvia
miltiorrhiza,
Tinospora
cordifolia,
Mucuna
pruriens,
Hydrocotyle
asiatica,
Bombax
ceiba,
Andrographis
paniculate,
utilised
There
a
variety
active
phytochemicals
found
these
some
which
include
flavonoids,
polyphenols,
plant
sterols,
sulphur
compounds,
terpenoids.
Flavonoids,
general,
increase
vasodilation
inhibiting
oxidation
low-density
lipoprotein
(LDL).
Plant
sterols
reduce
amount
cholesterol
blood,
turn
protects
against
compounds
protect
their
role
activation
nuclear
factor-erythroid
factor
2-related
2
(Nrf2)
inhibition
formation.
incidence
reduced
increasing
synthesis
ATP
mitochondria,
terpenoids
diminish
atherosclerotic
lesion
aortic
valve.
Even
though
several
physiologically
with
acknowledged
biological
functions
been
wide
prevalence
continues
rise,
making
imperative
effective
CVD
prevention
treatment
strategies
developed.
More
research
required
understand
both
mechanism
individual
plants
CVD.
GRAPHICAL
ABSTRACT
Язык: Английский
Tinospora cordifolia (Giloy): A Review of the Various Pharmacological Pathways of a Highly Potential Medicinal Ayurveda Plant
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(5), С. 267 - 278
Опубликована: Ноя. 25, 2024
Tinospora
cordifolia,
often
known
as
"Amrita"
or
"Guduchi,"
is
a
medication
that
played
significant
role
in
Indian
systems
of
medicine
(ISM)
and
has
been
utilised
the
treatment
many
ailments
since
beginning
time.
The
term
"guduchi"
comes
from
Sanskrit
language
translates
to
"which
protects
body
diseases."
There
another
name
for
this
herb,
"Amrita,"
which
reference
celestial
elixir
described
Hindu
mythology.
well-known
bitter
used
variety
conditions,
including
fevers,
diabetes,
dyspepsia,
jaundice,
urinary
issues,
skin
illnesses,
frequent
diarrhoea
dysentery.
Furthermore,
it
demonstrated
be
effective
cardiovascular
disorders,
leprosy,
helminthiasis,
rheumatoid
arthritis
syndrome.
In
addition
being
medicine,
preparations,
Satva,
Ghrita,
Tail,
Swarasa,
all
these.
An
examination
Charaka
Samhita,
Sushruta
Ashtanga
Hridaya,
Sangraha,
Bhavprakash
Nighantu,
Raj
Dhanvantari
Shaligrama
Priya
Kaiydev
Madanpal
Shodhal
well
internet
contemporary
medical
literature,
have
examined
review
article.
was
widespread
recognition
cordifolia
plant
possessed
high
degrees
medicinal,
therapeutic,
curative,
healing,
alleviating
properties.
By
virtue
its
anti-toxic,
anti-inflammatory,
anti-pyretic,
anti-oxidant
qualities,
guduchi
possesses
potential
therapeutic
application.
Moreover,
there
no
evidence
suggest
Guduchi
contains
any
hazardous
substances
adverse
effects,
further
demonstrates
safe
use.
Concluding
remarks:
medicinal
characteristics
(Giloy)
confirmed
by
studies
were
presented
review.
These
focus
on
safety
features
they
demonstrate
can
prevent
diseases
abnormalities
naturally
boosting
immunity
human
bodies.
Язык: Английский
A Review on Phytochemical and Ethano Pharmacology of Mallotus Philippnensis
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(5), С. 293 - 302
Опубликована: Окт. 31, 2024
Mallotus
philippinensis
(Lam.)
M
Arg
is
a
threatened
plant
species
in
the
central
ecoregion.
It
member
of
Euphorbiaceae
family.
Muell.
Arg.
(Family:
Euphorbiaceae)
significant
perennial
utilised
traditional
medicine.
primarily
prevalent
tropical
and
subtropical
climates
globally.
Despite
its
herbal
origin,
it
classified
within
one
eight
Sadharana
rasa
categories
[Glands
hairs
(Kampillaka),
Arsenic
(Somala),
Ammonium
Chloride
(Navasagara),
Cowri
(Kaparda),
Amber
(Agnijaara),
Red
Oxide
Mercury
(Girisindoora),
Cinnabar
(Hingula),
Litharge
(Muddaarashringa)]
Rasa-shastra,
Ayurvedic
study
minerals
metals.
M.
included
Virecana
ghana,
group
medicinal
plants
or
items
purgation
therapy
Primarily,
roots,
fruits
(including
fruit
powder),
leaves
are
for
therapeutic
applications.
The
possess
bitter
flavour
exhibit
cooling,
appetising
quality.
glands
advised
cutaneous
issues.
To
date,
research
investigations
have
been
conducted
to
validate
examine
pharmacological
properties
philippinensis.
This
document
aims
summarise
distribution,
morphology,
applications,
scientific
about
Researchers
empirically
demonstrated
antimicrobial,
hepatoprotective,
anti-leukemic,
anti-HIV,
anti-inflammatory,
anti-filarial,
analgesic,
hypnotic,
antiproliferative,
antifertility,
purgative,
anthelmintic,
antiallergic
activities
various
parts
Язык: Английский
Review on Phytochemical, Pharmacological and Marketed Product of Alovera Extract
Journal for Research in Applied Sciences and Biotechnology,
Год журнала:
2024,
Номер
3(6), С. 94 - 103
Опубликована: Дек. 28, 2024
Aloe
vera
has
historically
been
utilised
for
the
treatment
of
skin
injuries
(such
as
burns,
cuts,
insect
bites,
and
dermatitis)
digestive
issues
due
to
its
anti-inflammatory,
antibacterial,
wound-healing
attributes.
The
research
on
this
medicinal
plant
focusses
substantiating
traditional
applications
elucidating
mechanism
action,
well
identifying
chemicals
responsible
these
effects.
Similarly,
novel
effects
have
explored
active
constituents,
particularly
emphasising
potential
a
cytotoxic,
antitumoural,
anticancer,
antidiabetic
drug.
Over
past
six
years,
majority
pharmacological
comprised
in
vitro
vivo
trials.
In
predominantly
focus
antitumor,
protective
It
is
important
highlight
that
various
studies
assess
preventive
bone
disorders,
including
osteoporosis.
findings
protection
are
encouraging;
however,
it
essential
do
further
with
experimental
animals
humans.
designed
cardioprotective
effects,
cytotoxicity,
antitumor
anticancer
activities,
efficacy.
Clinical
trials
constrained
comparison
testing,
concentrating
mostly
dermal
Furthermore,
clinical
solely
vera,
excluding
isolated
components;
hence,
would
be
pertinent
investigate
therapeutic
significant
metabolites
across
human
diseases
illnesses.
Research
over
years
concentrated
principal
compounds:
aloe-emodin,
aloin,
aloesin,
amodin,
acemannan.
Aloe-emodin
aloin
most
extensively
researched
among
compounds.
emerged
drug
antidiabetic,
cardioprotective,
properties
investigations,
anti-inflammatory
research.
Aloin
shown
efficacy
inflammatory
processes
illnesses
(in
studies)
cancer
cardiovascular
studies).
encouraging
outcomes
fundamental
promote
an
increased
number
evaluate
application
primary
especially
regarding
protection,
cancer,
diabetes.
Язык: Английский