Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2024, Номер 3(2), С. 233 - 241

Опубликована: Май 25, 2024

The objective of this study is to improve the safety, efficacy, and rate action existing molecule by utilising novel techniques administration medication. This will be accomplished application approaches. Orally disintegrating pills containing rizatriptan benzoate were made direct compression technique in order provide migraine sufferers with a more expedient manner gaining relief from their condition. For purpose inquiry, 32-factororial design method was utilised, eight different formulations examined for each super disintegrants that explored. There number tests performed on batches tablets manufactured. These included weight variation, hardness, friability, wetting time, invitro dispersion drug content, dissolution. A UV spectrophotometric approach easy, sensitive, rapid, accurate, cost-effective, repeatable created identify dose form Rizatriptan Benzoate tablets. designed determine form. It has been determined maximum absorbance at wavelength 225 nm, its molar absorption measured 1.619 Ao. According Beer's law, law observed between 1 10 μg/ml. In validate conclusions investigation, statistical analysis recovery studies carried out. method, various criteria utilised. linearity, accuracy, limit detection (LOD), quantification (LOQ), Sandell's sensitivity, specificity among practice determining regular dosage both tablet bulk forms found one accurate precise via utilisation preferred method. identified through recommended time period ranging fifteen thirty seconds required optimised formulation distributed throughout body. Furthermore, it demonstrated greater water ratio released 99.60% medication over two minutes seconds. addition everything else shown.

Язык: Английский