Formulation & Evaluation of Anti Migrane Mouth Dissolving Tablet DOI Creative Commons

Jyotsna Upadhyay,

Amle Vandana Sonaji,

Farha Naaz

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(2), P. 233 - 241

Published: May 25, 2024

The objective of this study is to improve the safety, efficacy, and rate action existing molecule by utilising novel techniques administration medication. This will be accomplished application approaches. Orally disintegrating pills containing rizatriptan benzoate were made direct compression technique in order provide migraine sufferers with a more expedient manner gaining relief from their condition. For purpose inquiry, 32-factororial design method was utilised, eight different formulations examined for each super disintegrants that explored. There number tests performed on batches tablets manufactured. These included weight variation, hardness, friability, wetting time, invitro dispersion drug content, dissolution. A UV spectrophotometric approach easy, sensitive, rapid, accurate, cost-effective, repeatable created identify dose form Rizatriptan Benzoate tablets. designed determine form. It has been determined maximum absorbance at wavelength 225 nm, its molar absorption measured 1.619 Ao. According Beer's law, law observed between 1 10 μg/ml. In validate conclusions investigation, statistical analysis recovery studies carried out. method, various criteria utilised. linearity, accuracy, limit detection (LOD), quantification (LOQ), Sandell's sensitivity, specificity among practice determining regular dosage both tablet bulk forms found one accurate precise via utilisation preferred method. identified through recommended time period ranging fifteen thirty seconds required optimised formulation distributed throughout body. Furthermore, it demonstrated greater water ratio released 99.60% medication over two minutes seconds. addition everything else shown.

Language: Английский

Review on Nasal Drug Delivery System and Their Application DOI Creative Commons

Kanchan Tariyal

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(1), P. 281 - 285

Published: March 19, 2024

Nasal drug delivery has received a great deal of attention as convenient, reliable, and promising method for the systemic administration drugs. It is especially those molecules which are ineffective orally only effective if administered by injection. The nasal route advantages over other alternative systems non-invasive administration. present review an attempt to provide some information concerning system such limitations, advantages, mechanism absorption, anatomy cavity, factors affecting delivery, strategies enhance extend duration formulations within leading improved novel formulations, sorts with uses in various diseases, recent advancement systems.

Language: Английский

Citations

0
Formulation & Evaluation of Anti Migrane Mouth Dissolving Tablet DOI Creative Commons

Jyotsna Upadhyay,

Amle Vandana Sonaji,

Farha Naaz

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(2), P. 233 - 241

Published: May 25, 2024

The objective of this study is to improve the safety, efficacy, and rate action existing molecule by utilising novel techniques administration medication. This will be accomplished application approaches. Orally disintegrating pills containing rizatriptan benzoate were made direct compression technique in order provide migraine sufferers with a more expedient manner gaining relief from their condition. For purpose inquiry, 32-factororial design method was utilised, eight different formulations examined for each super disintegrants that explored. There number tests performed on batches tablets manufactured. These included weight variation, hardness, friability, wetting time, invitro dispersion drug content, dissolution. A UV spectrophotometric approach easy, sensitive, rapid, accurate, cost-effective, repeatable created identify dose form Rizatriptan Benzoate tablets. designed determine form. It has been determined maximum absorbance at wavelength 225 nm, its molar absorption measured 1.619 Ao. According Beer's law, law observed between 1 10 μg/ml. In validate conclusions investigation, statistical analysis recovery studies carried out. method, various criteria utilised. linearity, accuracy, limit detection (LOD), quantification (LOQ), Sandell's sensitivity, specificity among practice determining regular dosage both tablet bulk forms found one accurate precise via utilisation preferred method. identified through recommended time period ranging fifteen thirty seconds required optimised formulation distributed throughout body. Furthermore, it demonstrated greater water ratio released 99.60% medication over two minutes seconds. addition everything else shown.

Language: Английский

Citations

0