Bulletin of the Russian Military Medical Academy,
Год журнала:
2024,
Номер
26(4), С. 597 - 606
Опубликована: Дек. 16, 2024
The
study
evaluated
key
spirometric
parameters
in
patients
with
post-tuberculosis
(post-TB)
lung
sequelae
after
recovery
from
a
new
coronavirus
infection.
main
group
incliuded
14
clinically
cured
respiratory
tuberculosis
who
had
recovered
the
infection
and,
recovery,
were
sent
to
Glukhovskaya
sanatorium
for
treatment
2020-2021.
control
included
52
residual
post-TB
sequelae,
did
not
have
and
treated
at
during
same
period.
groups
comparable
terms
of
epidemiological
clinical
criteria,
except
sequelae:
13
cases
(92.9%)
minor
1
case
(7.1%)
major
36
(69.2%)
16
(30.8%)
cases,
respectively.
Pulmonary
function
tests
vital
capacity,
forced
expiratory
volume
second,
second/forced
capacity.
Tests
performed
admission
month.
At
stage
group,
capacity
second
on
average
below
predicted
level
(80%)
compared
improved
slightly.
In
initial
indicators
significantly
higher,
rates
lungs
2nd
examination,
levels
approached,
1st
they
reached
norm.
baseline,
low
ventilatory
correlated
symptoms,
as
42.8%
55.7%
controls
reported
shortness
breath.
However,
treatment,
more
often
showed
60%:
7.7%
17.3%
11.5%
while
mostly
slight
or
moderate
decrease
these
parameters.
Therefore,
has
negative
impact
functional
system,
but
also
contribute
development
disorders.
American Journal of Respiratory and Critical Care Medicine,
Год журнала:
2024,
Номер
210(8), С. 979 - 993
Опубликована: Авг. 14, 2024
Post-tuberculosis
(post-TB)
lung
disease
is
increasingly
recognized
as
a
major
contributor
to
the
global
burden
of
chronic
disease,
with
recent
estimates
indicating
that
over
half
TB
survivors
have
impaired
function
after
successful
completion
treatment.
However,
pathologic
mechanisms
contribute
post-TB
are
not
well
understood,
thus
limiting
development
therapeutic
interventions
improve
long-term
outcomes
TB.
This
report
summarizes
work
Pathogenesis
and
Risk
Factors
Committee
for
Second
International
Post-Tuberculosis
Symposium,
which
took
place
in
Stellenbosch,
South
Africa,
April
2023.
The
committee
first
identified
six
areas
high
translational
potential:
1)
tissue
matrix
destruction,
including
role
metalloproteinase
dysregulation
neutrophil
activity;
2)
fibroblasts
profibrotic
3)
granuloma
fate
cell
death
pathways;
4)
mycobacterial
factors,
pathogen
burden;
5)
animal
models;
6)
impact
key
clinical
risk
HIV,
diabetes,
smoking,
malnutrition,
alcohol.
We
share
findings
from
literature
review
those
areas,
highlighting
knowledge
gaps
where
further
research
needed.
Deleted Journal,
Год журнала:
2025,
Номер
2(1), С. 1 - 2
Опубликована: Янв. 1, 2025
One
year
on
from
the
launch
of
our
new
open
access
(OA)
journal,
IJTLD
OPEN,
we
review
its
impact.
Similar
to
flagship
IJTLD,
articles
published
in
OPEN
span
a
range
topics
related
lung
health
and
majority
focus
TB
low-
middle-income
countries
(LMICs).
Interestingly,
there
has
been
no
lag
period
readers
accessing
content,
with
downloads
for
soon
matching
exceeding
those
IJTLD.
This
demonstrates
that
OA
is
helping
us
achieve
goal
improving
knowledge
dissemination
LMICs,
where
restricted
subscription
journals.
Citation
analysis
first
few
issues
also
suggests
this
higher
level
leading
being
cited
at
an
accelerated
rate.
Pathogens and Immunity,
Год журнала:
2025,
Номер
10(2), С. 1 - 45
Опубликована: Март 2, 2025
In
the
field
of
tuberculosis
and
non-tuberculous
mycobacterial
(NTM)
disease
we
are
looking
back
on
an
exciting
year
2024
with
more
than
10,000
publications
listed
in
PubMed.
Our
aim,
to
review
scientific
literature
2024,
is
challenged
by
enormous
number
publications.
Therefore,
if
your
article
not
included
or
favorite
mycobacteriology
covered,
please
forgive
us.
"Year
Review"
very
much
clinically
oriented
lesser
emphasis
basic
science,
microbiology,
biotechnology.
Members
steering
committee
Tuberculosis
Network
European
Trials
group
(TBnet;
www.tbnet.eu)
report
139
fields
epidemiology,
prevention,
diagnosis,
treatment
NTM
diseases
published
that
found
particularly
important.
We
separately
for
children
adults
provide
a
brief
overview
newer
technologies
diagnostic
pipeline.
Furthermore,
summarize
priorities
research,
development,
implementation,
all
which
represent
perspective
our
combined
clinical
experience.
This
Year
Review
provides
concise
summary
relevant
highlights
2024.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 7, 2025
It
is
estimated
that
more
than
150
million
individuals
alive
in
2020
had
survived
tuberculosis
(TB).
A
portion
of
this
large
population
continues
to
experience
chronic
respiratory
abnormalities,
with
or
without
symptoms,
due
previous
active
pulmonary
TB.
This
condition
known
as
Post-TB
Lung
Disease
(PTLD),
involves
a
complex
interaction
between
pathogen,
host
and
environmental
factors.
These
interactions
are
believed
drive
hyperinflammatory
process
the
lungs
during
TB,
resulting
tissue
damage,
which
may
lead
radiological
sequelae,
impaired
function,
clinical
such
cough,
dyspnea,
hemoptysis,
infections.
Such
complications
impose
significant
health,
financial,
social
burdens,
remain
poorly
understood
inadequately
addressed
by
health
care
systems.
Given
heterogeneity
immune
cells
their
products
infiltrating
airways
lung
parenchyma
acute
inflammation
caused
Mycobacterium
infection,
it
evident
TB
immunopathology
multifactorial.
Among
various
components
involved,
neutrophils
have
recently
emerged
critical
contributors
deleterious
response
against
leading
severe
damage.
In
translational
narrative
review,
we
aim
summarize
role
primary
-
proteases
(such
elastase),
matrix
metalloproteinases
extracellular
traps
(NETs)
We
highlight
new
concepts
emerging
evidence
neutrophil
involvement
disease,
translating
these
insights
from
"bench
bedside"
facilitate
dialogue
fundamental
researchers
practitioners.
Additionally,
present
potential
targets
for
future
treatment
strategies
could
mitigate
even
prevent
PTLD.
Deleted Journal,
Год журнала:
2025,
Номер
2(5), С. 248 - 250
Опубликована: Май 9, 2025
Although
much
attention
is
given
to
diagnosis
and
treatment
for
TB,
recent
evidence
highlights
the
suffering
that
occurs
after
patients
are
‘cured’.
This
issue
of
IJTLD
Open
includes
two
studies
improve
our
understanding
long-term
impact
TB.
First,
a
study
in
Kenya,
Uganda,
Zambia
Zimbabwe
evaluated
feasibility
assessing
referring
TB
comorbidities,
risk
factors
disabilities
within
national
programmes.
Second,
who
successfully
completed
China
sheds
light
on
sequelae
The
combined
findings
reinforce
need
integrate
care
strategies
into
programmes
address
these
health
challenges.
Health and Quality of Life Outcomes,
Год журнала:
2024,
Номер
22(1)
Опубликована: Окт. 29, 2024
Abstract
Background
Health-related
quality
of
life
(HRQoL)
is
a
crucial
patient-centred
outcome
for
developing
policy.
However,
there
lack
appropriate
HRQoL
measures
young
children
(0-5-years),
who
are
particularly
vulnerable
to
respiratory
illnesses
like
pulmonary
tuberculosis
(PTB)
and
other
infections,
especially
in
low-
middle-income
countries
(LMICs).
We
aimed
develop
disease-specific
item
bank
with
acute
chronic
illnesses.
Methods
An
exploratory
sequential
design
three
phases
was
used
bank.
The
content
validity
the
evaluated
by
local
international
experts
specialising
child
health.
group
included
paediatric
pulmonologists,
researchers
expertise
illnesses,
scale
development.
Cognitive
interviews
37
caregivers
TB,
pneumonia,
adenovirus
infection,
lower
tract
reactive
airway
disease,
protracted
bronchitis
Cape
Town,
South
Africa,
consultations
22
stakeholders
were
conducted
final
revisions.
progressively
refined
at
each
phase
study.
Findings
Delphi
recommended
dividing
into
two
age
groups
(0-2-years
3-5-years)
using
5-point
Likert
scale.
Overall,
41
items
(42%)
met
predetermined
>
70%
threshold
inclusion
confirmed
that
domains
relevant.
Minor
modifications
made
five
cohort
1
(0-2-years)
seven
2
(3-5-years),
8
(13%)
14
(22%)
excluded.
Phase
3
emphasised
importance
including
all
expanding
cover
early
childhood
development,
play,
social
interactions,
care
routines.
includes
versions
both
incorporates
these
refinements.
Conclusion
developed
as
first
step
comprehensive
tool
an
LMIC.
Input
from
creating
banks
tailored
developmental
differences
between
0
3-5-year
groups.
Their
contributions
ensured
effectively
captures
age-appropriate
aspects
HRQoL.
Future
studies
should
focus
on
assessing
reliability
banks.
Deleted Journal,
Год журнала:
2024,
Номер
1(12), С. 531 - 532
Опубликована: Дек. 1, 2024
It
is
now
well
understood
that
the
effect
of
TB
does
not
always
end
when
a
patient
completes
successful
course
treatment.
Successful
treatment
by
definition
microbiological
cure,
but
people
may
continue
to
suffer
consequences
for
months
or
years
after
For
example,
ongoing
health
challenges
can
present
in
form
post-TB
lung
disease
(PTLD),
and
there
high
incidence
TB-related
symptoms
associated
with
disability
other
domains.
We
discuss
an
article
this
issue