Adjusting to dementia as part of life: an actantial analysis of agency reconstruction following diagnosis of young onset dementia DOI Creative Commons
Katja Hautsalo, Jari Pirhonen,

Ikka Pietilä

и другие.

Ageing and Society, Год журнала: 2024, Номер unknown, С. 1 - 27

Опубликована: Ноя. 22, 2024

Abstract The agency of a person with young onset dementia (YOD) changes owing to individual symptoms, uncertainty about the speed progression and severity YOD. Dementia usually greatly interrupts life reduces agency. Previous studies show that some people families integrate cope better than others. This study aimed find out how YOD who has it what family members’ role is in forming their data were collected Finland semi-structured interviews 14 15 members, year after diagnosis. These two sets analysed narrative method, actantial analysis. A wide variety elements, both human non-human factors, found promote undermine It was need integrity flexibility reconstruct own Resources support them this process reconstruction, hinderers interrupt process. combination flexibility, resources hinderers, generates recount future, aims they set Other people, especially are part dynamic when relationship cohesive, parties increases. participants used ideal burdensome storylines narrate factors supported or interrupted Based on our findings, narrating one’s situation is, for coping, not only means but its very basis.

Язык: Английский

Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study DOI
Shuai Yuan, Lintao Dan, Yao Zhang

и другие.

American Journal of Preventive Medicine, Год журнала: 2023, Номер 66(3), С. 516 - 525

Опубликована: Окт. 31, 2023

Язык: Английский

Процитировано

9
Electroencephalography in young onset dementia DOI Creative Commons
C Brown, Huei-Yang Chen, Peter K. Panegyres

и другие.

BMC Neurology, Год журнала: 2023, Номер 23(1)

Опубликована: Май 23, 2023

Abstract Background Young onset dementia (YOD) is a major diagnostic and management problem. Methods We set out to explore if electroencephalography (EEG) might be useful in the diagnosis of young Alzheimer’s disease (YOAD) frontotemporal (YOFTD). The ARTEMIS project 25-year prospective study YOD based Perth, Western Australia. 231 participants were included: YOAD: n = 103, YOFTD: 28, controls: 100. EEGs performed prospectively, with 30-minute recording time for each subject, without knowledge or other data. Results 80.9% patients had abnormal ( P < 0.00001). Slow wave changes more frequent YOAD that YOFTD 0.00001), but no difference frequency epileptiform activity 0.32), 38.8% 28.6% having activity. generalized 0.001). not sensitive YOD, highly specific (97–99%). absence slow 100% negative predictive value likelihood radio 0.14 0.62 respectively, meaning those low probability YOD. No relationship was established between EEG findings patient’s presenting Eleven developed seizures during study, only one YOFTD. Conclusions phenomena making unlikely, diagnosis.

Язык: Английский

Процитировано

6
Cell primitive-based biomimetic nanomaterials for Alzheimer's disease targeting and therapy DOI Creative Commons
Tong Yin, Yan Liu, Bin He

и другие.

Materials Today Bio, Год журнала: 2023, Номер 22, С. 100789 - 100789

Опубликована: Сен. 1, 2023

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which not just confined to the older population. Although developments have been made in AD treatment, various limitations remain be addressed. These are partly contributed by biological hurdles, such as blood–brain barrier and peripheral side effects, well lack of carriers that can efficiently deliver therapeutics brain while preserving their therapeutic efficacy. The increasing prevalence unavailability effective treatments encouraged researchers develop improved, convenient, affordable therapies. Functional materials based on primitive cells nanotechnology emerging attractive treatment. Cell primitives possess distinct functions, including long-term circulation, lesion site targeting, immune suppression. This review summarizes challenges delivery drugs recent advances cell primitive–based for Various primitives, cells, extracellular vesicles, membranes, presented together with distinctive functions construction strategies. Moreover, future research directions discussed basis foreseeable perspectives.

Язык: Английский

Процитировано

6
Peer Support for Caregivers of People Living with Posterior Cortical Atrophy in Melbourne, Australia: A Feasibility Study DOI Open Access

A. R. K. Mitchell,

Wendy Kelso, Camille Paynter

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(4), С. 513 - 513

Опубликована: Апрель 22, 2024

Posterior Cortical Atrophy (PCA) is a rare form of young-onset dementia that causes early visuospatial and visuoperceptual deficits. The symptom profile leads to very specific care needs for those affected, who often rely on informal caregivers (including friends family). Rare support groups can be useful both patients their assist with knowledge sharing, psychoeducation, the provision psychosocial support. Despite this, few such exist. purpose this study was examine PCA group individuals living PCA. We held structured psychoeducation comprised four sessions aim being provide education, strategies management disease, peer Caregivers’ mental health quality life were assessed. results our showed participation positive experience assisted increasing fostering social connections. suggest may beneficial people caregivers. recommend future quantitative qualitative research conducted further assess health-promotion benefits caregivers, development implementation in different contexts.

Язык: Английский

Процитировано

1
Heat-related illness and dementia: a study integrating epidemiological and experimental evidence DOI Creative Commons
Wan-Yin Kuo, Chien–Cheng Huang, Chi‐An Chen

и другие.

Alzheimer s Research & Therapy, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 3, 2024

Abstract Background Heat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We conducted a population-based cohort study animal experiment to evaluate whether HRI associated with dementia later in life. Methods The Taiwan National Health Insurance Research Database was used the epidemiological study. identified newly diagnosed patients between 2001 2015, but excluded those any pre-existing dementia, as cohort. Through matching by age, sex, index date cohort, we selected individuals without comparison at 1:4 ratio. followed each member until end of 2018 compared risk two cohorts using Cox proportional hazards regression models. In experiment, rat model assess cognitive functions histopathological changes hippocampus after heat stroke event. Results study, consisted 70,721 282,884 HRI. After adjusting for confounders, had higher (adjusted hazard ratio [AHR] = 1.24; 95% confidence interval [CI]: 1.19–1.29). Patients (AHR 1.26; CI: 1.18–1.34). found dysfunction evidenced behavioral tests observed remarkable neuronal damage, degeneration, apoptosis, amyloid plaque deposition Conclusions Our indicated that elevated dementia. This finding substantiated features hippocampus, along impairments detected, experimental model.

Язык: Английский

Процитировано

1
Clinical application of whole genome sequencing in young onset dementia: challenges and opportunities DOI
Aamira Huq, Bryony A. Thompson, Ingrid Winship

и другие.

Expert Review of Molecular Diagnostics, Год журнала: 2024, Номер 24(8), С. 659 - 675

Опубликована: Авг. 2, 2024

Introduction Young onset dementia (YOD) by its nature is difficult to diagnose. Despite involvement of multidisciplinary neurogenetics services, patients with YOD and their families face significant diagnostic delays. Genetic testing for people currently involves a staggered, iterative approach. There no optimal single genetic investigation that simultaneously identifies the different variants resulting in YOD.

Язык: Английский

Процитировано

1
Interventions for Persons with Young-Onset Dementia and Their Families: A Scoping Review DOI
Xiaoyan Cui, Junqiao Wang, Bei Wu

и другие.

Journal of Alzheimer s Disease, Год журнала: 2024, Номер 97(4), С. 1519 - 1531

Опубликована: Янв. 23, 2024

Dementia occurring before age 65 is known as young-onset dementia (YOD), with Alzheimer's disease being the most common type. YOD poses unique challenges for persons and families, impacting their working-age years family responsibilities. Person-centered interventions services are essential to improve quality of life social engagement.

Язык: Английский

Процитировано

0
Young-onset dementia following chronic abuse of amphetamine-type stimulants DOI Creative Commons
Sultan H. Alamri

Pakistan Journal of Medical Sciences, Год журнала: 2024, Номер 40(4)

Опубликована: Фев. 7, 2024

Young-onset dementia (YOD) is influenced by various risk factors, including substance abuse. In this report, we present the case of a 54-year-old man who developed YOD following prolonged abuse amphetamine-type stimulants. The patient exhibited insidious cognitive decline over three-year period before seeking medical attention. Neuroimaging revealed atrophy temporal lobe, suggesting connection between amphetamine-induced neurotoxicity and abnormalities observed in condition. Our highlights importance considering stimulants as potential factors for emphasizes need to recognize impairment resulting from Additionally, look into relevant literature provide further context insights. doi: https://doi.org/10.12669/pjms.40.4.8737 How cite this: Alamri SH. chronic Pak J Med Sci. 2024;40(4):779-781. This an Open Access article distributed under terms Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, reproduction any medium, provided original work properly cited.

Язык: Английский

Процитировано

0
The impact on employment and education of caregiving for a family member with young onset dementia: A scoping review DOI
Kristina M. Kokorelias,

Nirusa Nadesar,

Katherine Bak

и другие.

Dementia, Год журнала: 2024, Номер 23(5), С. 850 - 881

Опубликована: Апрель 16, 2024

Young-onset dementia (YOD) affects individuals under 65 years of age, often leading to loss employment and independence. Families provide increasing levels care family members with YOD, resulting in changes their daily lives, including occupational pursuits. This review examines evidence the implications for who a YOD identify: (i) influence impact caregiving tasks responsibilities have on employment, volunteering, education, (ii) caregiver, situation factors associated education. A scoping was performed using eight electronic databases. Included articles were narratively synthesized thematic analysis. Sixteen studies met inclusion criteria included review. The over-arching (main) theme 'decision-making' identified, required make choices about own goals roles be able living YOD. outcomes these decisions are dynamic changeable across trajectory. Three decision-making: (1) Implications Combining Caregiving Occupations, (2) Altered Identity (3) Strategies Support Caregivers Individuals Living fourth also identified 'Guidance Researchers To Caregivers'. There is scarce body literature examining has caregiver population. Much this work descriptive lacks focus implications, particularly long-term impacts. provides foundational guide future research practices support caregivers obtain sustain occupations.

Язык: Английский

Процитировано

0
Mentalising imagery therapy for family dementia caregivers: protocol for a scoping review DOI Creative Commons

Xue Jiang,

Hu Jiang

BMJ Open, Год журнала: 2024, Номер 14(5), С. e076727 - e076727

Опубликована: Май 1, 2024

Introduction Dementia is a growing public health concern, and providing long-term care for individuals affected by this condition challenging their family caregivers. While researchers have explored various intervention options to provide psychological support dementia caregivers, mentalising imagery therapy (MIT) has gained significant recognition as an effective programme. Despite its significance effectiveness, there lack of comprehensive scoping reviews MIT in caregiving. Thus, conducting such review can valuable insights into the status outcomes MIT, identify gaps existing research recommendations more clinical practice. Methods analysis This study proposes conducted according Joanna Briggs Institute, Arksey O’Malley’s methodological framework, well Preferred Reporting Items Systematic Reviews Meta-Analyses-Scoping Review Extension. PubMed, Web Science, Embase, Scopus, CINAHL PsycINFO databases will be searched while grey literature retrieved via Google Scholar. Covidence used manage selection process remove duplicate publications. Two independently screen inclusion criteria, with any discrepancies resolved through discussions third researcher. Data presented structured tabular format, narrative synthesis overview findings on identified effectiveness field Ethics dissemination In review, no ethical approval necessary. The results published peer-reviewed journal. Trial registration number protocol been registered Open Science Framework ( https://doi.org/10.17605/OSF.IO/FHRG8 ).

Язык: Английский

Процитировано

0