Cyanation with isocyanides: recent advances and perspectives

Chemical Communications, Год журнала: 2024, Номер 60(12), С. 1546 - 1562

Опубликована: Янв. 1, 2024

This review focuses on the cyanation of isocyanides with recent advances and perspectives.

Язык: Английский

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Pd-catalyzed imine-directed one-pot access to polysubstituted pyrrolesviatandem triple isocyanide insertion/aza-Nazarov cyclization reactions

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(13), С. 3252 - 3258

Опубликована: Янв. 1, 2023

A novel one-pot method for synthesizing polysubstituted pyrrole derivatives via three-component reactions of alkenyl bromides, amines, and isocyanides is reported by Pd catalysis, without additional ligands, with the orderly insertion three isocyanide molecules.

Язык: Английский

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Unlocking Isonitrile Insertion with N-Centered Radicals: A General Synthetic Strategy toward Quinazolinone Alkaloids by Synergistic Photo/Copper Catalysis

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 5307 - 5317

Опубликована: Март 16, 2025

Язык: Английский

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Tuning the electronic states of Pd(II) defect-engineered metal-organic framework catalysts for efficient conversion of isocyanides

Communications Chemistry, Год журнала: 2025, Номер 8(1)

Опубликована: Апрель 5, 2025

Recently, defective sites in MOFs have become an important tool for tuning the catalytic performance of MOFs. Herein, we report a heterogeneous catalyst "Pd-UiO-67(N)x" by utilizing active site MOF to modulate electronic state Pd, which demonstrates excellent performances oxidative cyclization reaction isocyanides with o-aminophenols benefiting from electron-deficient nature Pd species. When loading Pd-UiO-67(N)x system was decreased 0.37 mol %, efficiency significantly enhanced and turnover number (TON) increased 232, 27 2.6 times higher than that homogeneous catalysts defect-free Pd-UiO-67(N)0, respectively. The open pore structure d-MOFs supports adsorption o-aminophenols. Additionally, domain-limiting effect framework restricts aggregation resulting good stability species, without significant loss its activity five consecutive cycles. This work provides insight into improvement stereoelectronic properties organometallic through defect-engineered

Язык: Английский

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Hydrogen bond-promoted regio- and stereoselective synthesis of isoindoline derivatives through Pd-catalyzed isocyanide insertion reaction involving aziridines

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(6), С. 1775 - 1781

Опубликована: Янв. 1, 2024

We have successfully demonstrated an efficient and practical Pd-catalyzed reaction between aziridine isocyanide, leading to the synthesis of isoindoline derivatives in moderate good yields.

Язык: Английский

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Silver‐Catalyzed and Silver‐Promoted Reactions of Isocyanides

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(23)

Опубликована: Май 5, 2023

Abstract In recent years, the silver‐catalyzed and silver‐promoted isocyanide reactions have attracted much attention, due to its efficiency in formation of diverse new bonds good reaction selectivity. A series highly useful linear or cyclic compounds been constructed. this review, progress field is described sequence synthesis five‐membered heterocyclic compounds, six‐membered fused as well nitrogen‐containing compounds.

Язык: Английский

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Rapid Access to Fused Tetracyclic N-Heterocycles via Amino-to-Alkyl 1,5-Palladium Migration Coupled with Intramolecular C(sp³)–C(sp²) Coupling

Organic Letters, Год журнала: 2023, Номер 25(34), С. 6272 - 6277

Опубликована: Авг. 21, 2023

An unprecedented route for the preparation of fused tetracyclic N-heterocycles is presented through palladium-catalyzed cyclization isocyanides with alkyne-tethered aryl iodides. In this transformation, a novel amino-to-alkyl 1,5-palladium migration/intramolecular C(sp3)-C(sp2) coupling sequence was observed first. More importantly, isocyanide exhibited three roles, serving simultaneously as C1 synthon, C1N1 and donor C(sp3) coupling, reaction sole successful example that achieved C(sp3)-H activation isocyanide.

Язык: Английский

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Design, synthesis, crystal structure and DFT analysis of (E)-N-(tert-butyl)-11H-benzo[4,5]imidazo[2,1-a]isoindol-11-imines with dual-state emission property

Journal of Molecular Structure, Год журнала: 2023, Номер 1299, С. 137217 - 137217

Опубликована: Дек. 1, 2023

Язык: Английский

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