Visible-Light-Induced Divergent C–H Esterification/Alkylation of Quinoxalin-2(1H)-ones with Aldehydes under Mild Conditions
Organic Letters,
Год журнала:
2025,
Номер
27(10), С. 2526 - 2531
Опубликована: Март 5, 2025
Herein,
we
introduce
an
efficient
and
straightforward
strategy
for
the
selective
C-H
esterification
alkylation
of
quinoxalin-2(1H)-ones
with
aldehydes.
A
key
feature
our
study
is
ability
to
perform
both
using
different
types
The
reaction
system
highly
compatible
a
range
aldehydes,
yielding
C3-esterified
C3-alkylated
products
in
moderate-to-good
yields.
applicability
this
approach
further
enhanced
by
its
scalability
through
continuous-flow
synthesis,
late-stage
modification
significant
molecules,
product
derivatization.
Our
mechanistic
investigations
reveal
radical
relay
mechanism,
triggered
hydrogen
atom
transfer
process.
Язык: Английский
Synthesis of Indole-Fused Benzodiazepine Derivatives by Photocatalyzed Cascade Reaction
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
We
report
a
cascade
synthesis
of
indole-fused
benzodiazepines
by
the
photocatalyzed
addition
phenacyl
radical,
generated
from
α-acetoxy
acetophenone,
to
2-(3-methyl-1H-indol-1-yl)aniline,
and
subsequent
cyclodehydration.
A
range
were
obtained
readily
available
substrates.
Язык: Английский
Visible Light-Induced Photocatalyst-Free Diastereoselective Iodosulfonylation of Cyclopropenes in Water
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
This
study
presents
a
greener
approach
to
the
visible-light-induced
micellar-catalyzed
diastereoselective
iodosulfonylation
of
cyclopropenes
in
water
medium.
Remarkably,
this
process
operates
without
photocatalyst.
Instead,
it
utilizes
an
electron-donor–acceptor
complex
formed
between
sulfonyl
chloride
and
sodium
iodide.
method
is
highly
efficient
broadly
applicable
for
both
aromatic
aliphatic
chlorides.
Furthermore,
protocol
enables
transformation
iodosulfonated
cyclopropanes
into
sulfonated
cyclopropenes,
highlighting
its
substantial
value
as
versatile
powerful
tool
synthetic
chemistry.
Язык: Английский