Modular Construction of Chiral Aminopiperidine via Palladium-Catalyzed Hydroamination of 1,2-Dihydropyridine
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 12, 2025
In
this
study,
we
describe
a
generally
straightforward
methodology
for
the
catalytic
synthesis
of
chiral
aminopiperidine
from
pyridine
and
azoles.
The
key
step
was
palladium-catalyzed
regioselective
N–H
insertion
into
double
bond
1,2-dihydropyridine.
This
hydroamination
exhibits
wide
substrate
scope
functional
group
compatibility.
Mechanistic
study
revealed
that
C═C
followed
cis
addition.
utility
protocol
demonstrated
by
diverse
functionalization
enamine
bond.
Язык: Английский
Catalytic Atroposelective Construction of Furan‐Based Axially Chiral Scaffolds
ChemCatChem,
Год журнала:
2024,
Номер
16(21)
Опубликована: Июль 19, 2024
Abstract
Axially
chiral
furan‐based
scaffolds
have
been
recognized
as
a
class
of
important
five‐membered
heteroaryl
atropisomers,
and
developing
catalytic
atroposelective
reactions
for
constructing
this
is
highly
desirable.
However,
the
construction
such
rather
underdeveloped
due
to
existence
great
challenges
remote
ortho
‐substituents
weak
configurational
stability.
To
overcome
these
challenges,
synthetic
chemists
recently
paid
attention
research
field,
number
axially
constructed
via
using
different
strategies.
This
concept
summarized
advances
in
field
pointed
out
remaining
which
will
promote
further
development
emerging
field.
Язык: Английский