Modular Construction of Chiral Aminopiperidine via Palladium-Catalyzed Hydroamination of 1,2-Dihydropyridine

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

In this study, we describe a generally straightforward methodology for the catalytic synthesis of chiral aminopiperidine from pyridine and azoles. The key step was palladium-catalyzed regioselective N–H insertion into double bond 1,2-dihydropyridine. This hydroamination exhibits wide substrate scope functional group compatibility. Mechanistic study revealed that C═C followed cis addition. utility protocol demonstrated by diverse functionalization enamine bond.

Language: Английский

Catalytic Atroposelective Construction of Furan‐Based Axially Chiral Scaffolds

ChemCatChem, Journal Year: 2024, Volume and Issue: 16(21)

Published: July 19, 2024

Abstract Axially chiral furan‐based scaffolds have been recognized as a class of important five‐membered heteroaryl atropisomers, and developing catalytic atroposelective reactions for constructing this is highly desirable. However, the construction such rather underdeveloped due to existence great challenges remote ortho ‐substituents weak configurational stability. To overcome these challenges, synthetic chemists recently paid attention research field, number axially constructed via using different strategies. This concept summarized advances in field pointed out remaining which will promote further development emerging field.

Language: Английский