Journal of Science Advanced Materials and Devices,
Год журнала:
2024,
Номер
9(3), С. 100761 - 100761
Опубликована: Июнь 25, 2024
The
annual
prevalence
of
gastric
cancer
has
increased
in
recent
years.
Curcumin
(CUR)
shown
great
potential
the
treatment
cancer;
however,
its
low
bioavailability
and
poor
efficacy
hinder
widespread
clinical
application.
Additionally,
CUR
been
found
to
be
excellent
photosensitizer
photodynamic
therapy.
In
this
study,
Fe-based
metal-organic
framework
(MOF)
Fe
Tetrakis
(4-carboxyphenyl)
porphyrin
(Fe-TCPP,FT)
was
used
as
a
mononuclear
agent.
natural
anti-tumor
active
ingredient
loaded
both
chemotherapeutic
agent
form
nanoparticles
CUR@FT
(CF).
Finally,
cell-penetrating
peptide
(CPP10)
modified
on
surface
construct
drug
delivery
system
(named
CPP10-PEG@CUR@FT,
CCF)
that
could
actively
target
tumor
cells
while
exerting
synergistic
therapeutic
effect
chemotherapy
This
can
improve
or
photosensitizer,
high
load
pH
sensitivity
FT
provide
an
carrier
for
efficient
CUR.
polyethene
glycol
(PEG)-conjugated
CPP10
(PEG-CPP10)
coating
allows
specifically
cells,
significantly
improving
absorption
vivo
vitro
biosafety.
We
evaluated
thermal
stability,
loading
capacity,
safety
vehicle.
also
assessed
performance
toxicity
various
targeting
biocompatibility
CPP10-PEG@CUR@FT.
CPP10-PEG@CUR@FT
killing
(MKN45)
under
light
much
stronger
than
free
Its
side
effects
other
organs
tissues
are
low,
offering
good
experimental
results
showed
exerted
therapy
chemotherapy.
summary,
our
novel
CUR-loaded
targeted
nano
offers
significant
advantages
by
combining
treatment.
approach
introduces
new
concept
integrating
chemotherapy,
delivery,
potentially
providing
strategy
cancer.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 1, 2024
Abstract
Background
Uveal
melanoma
(UM),
the
most
common
adult
intraocular
tumor,
is
characterized
by
high
malignancy
and
poor
prognosis
in
advanced
stages.
Angiogenesis
critical
for
UM
development,
however,
not
only
role
of
vascular
endothelial
dysfunction
remains
unknown,
but
also
their
analysis
at
single-cell
level
has
been
lacking.
A
comprehensive
essential
to
clarify
endothelium
development
UM.
Methods
By
using
RNA
transcriptomics
data
11
cases
primary
liver
metastasis
UM,
we
analyzed
cell
status.
In
addition,
validated
ECs
vitro
model
collected
clinical
specimens.
Subsequently,
explored
impact
on
migration
mechanisms
responsible
abnormalities
reasons
peripheral
effects.
Results
a
significantly
higher
percentage
cells
compared
situ
tumors,
show
significant
senescence.
Senescent
metastatic
tumors
showed
Krüppel-like
factor
4
(KLF4)
upregulation,
overexpression
KLF4
normal
induced
senescence,
knockdown
senescent
inhibited
suggesting
that
driver
gene
KLF4-induced
senescence
drove
tumor
through
senescence-associated
secretory
phenotype
(SASP),
which
important
component
effector
was
CXCL12
(C-X-C
motif
chemokine
ligand
12),
participated
composition
immunosuppressive
microenvironment.
Conclusion
This
study
provides
an
undesirable
insight
promoting
metastasis.
Frontiers in Nanotechnology,
Год журнала:
2024,
Номер
6
Опубликована: Июль 11, 2024
The
6th-generation
(6G)
sensing
technology
is
transforming
the
ways
we
perceive
and
interact
with
world
in
real
scenarios.
It
combines
advanced
materials,
sophisticated
algorithms,
connectivity
to
create
intelligent,
context-aware
systems
that
can
interpret
respond
environmental
stimuli
unprecedented
accuracy
speed.
key
advancements
include
1)
ultra-sensitive
sensors
capable
of
detecting
physical,
chemical,
biological
changes
at
low
concentrations,
2)
integration
artificial
intelligence
(AI)
machine
learning
(ML)
for
enhanced
data
processing,
3)
deployment
IoT
networks
5
th
-generation
(5G)
seamless
transmission
real-time
analysis.
These
cutting-edge
technologies
immersive
environments
where
devices
capture
anticipate
user
needs
conditions.
6G
has
potential
applications
across
sectors
like
point-of-care
(PoC),
healthcare,
urban
planning,
monitoring.
transition
from
sense-making
represents
a
paradigm
shift,
fostering
more
intuitive,
responsive,
interconnected
world.
article
provides
comprehensive
overview
current
state
prospects
technology,
highlighting
its
transformative
challenges
realizing
full
capabilities.
Journal of Science Advanced Materials and Devices,
Год журнала:
2024,
Номер
9(3), С. 100761 - 100761
Опубликована: Июнь 25, 2024
The
annual
prevalence
of
gastric
cancer
has
increased
in
recent
years.
Curcumin
(CUR)
shown
great
potential
the
treatment
cancer;
however,
its
low
bioavailability
and
poor
efficacy
hinder
widespread
clinical
application.
Additionally,
CUR
been
found
to
be
excellent
photosensitizer
photodynamic
therapy.
In
this
study,
Fe-based
metal-organic
framework
(MOF)
Fe
Tetrakis
(4-carboxyphenyl)
porphyrin
(Fe-TCPP,FT)
was
used
as
a
mononuclear
agent.
natural
anti-tumor
active
ingredient
loaded
both
chemotherapeutic
agent
form
nanoparticles
CUR@FT
(CF).
Finally,
cell-penetrating
peptide
(CPP10)
modified
on
surface
construct
drug
delivery
system
(named
CPP10-PEG@CUR@FT,
CCF)
that
could
actively
target
tumor
cells
while
exerting
synergistic
therapeutic
effect
chemotherapy
This
can
improve
or
photosensitizer,
high
load
pH
sensitivity
FT
provide
an
carrier
for
efficient
CUR.
polyethene
glycol
(PEG)-conjugated
CPP10
(PEG-CPP10)
coating
allows
specifically
cells,
significantly
improving
absorption
vivo
vitro
biosafety.
We
evaluated
thermal
stability,
loading
capacity,
safety
vehicle.
also
assessed
performance
toxicity
various
targeting
biocompatibility
CPP10-PEG@CUR@FT.
CPP10-PEG@CUR@FT
killing
(MKN45)
under
light
much
stronger
than
free
Its
side
effects
other
organs
tissues
are
low,
offering
good
experimental
results
showed
exerted
therapy
chemotherapy.
summary,
our
novel
CUR-loaded
targeted
nano
offers
significant
advantages
by
combining
treatment.
approach
introduces
new
concept
integrating
chemotherapy,
delivery,
potentially
providing
strategy
cancer.
