Deprivation-induced plasticity in the early central circuits of the rodent visual, auditory, and olfactory systems: a systematic review and meta-analysis of the literature DOI Creative Commons
Li Huang, Francesca Hardyman, Megan Edwards

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 5, 2023

Abstract Activity-dependent neuronal plasticity is crucial for animals to adapt dynamic sensory environments. Traditionally, research on activity dependent-plasticity has used deprivation approaches in animal models, and it focused its effects primary cortices. However, emerging evidence emphasizes the importance of activity-dependent both organs sub-cortical regions where cranial nerves relay information brain. Additionally, a critical question arises: do different modalities share common cellular mechanisms deprivation-induced at these central entry-points? Furthermore, does duration correlate with specific mechanisms? This study aims systematically review meta-analyse papers that investigated visual, auditory, or olfactory rodents. Specifically, explores consequences homologous first synapse after nerve: vision—lateral geniculate nucleus superior colliculus; audition— ventral dorsal cochlear nucleus; olfaction—olfactory bulb. The systematic search yielded 91 (39 vision, 22 audition, 30 olfaction), revealing significant heterogeneity publication trends, experimental methods inducing deprivation, measures plasticity, reporting, across three modalities. Nevertheless, despite methodological differences, commonalities emerged when correlating deprivation. Following short-term deprivations (up 1 day) all systems showed reduced levels increased disinhibition. Medium-term (1 day week) induced greater glial involvement synaptic remodelling. Long-term (over predominantly led macroscopic structural changes including tissue shrinkage apoptosis. These findings underscore standardizing methodologies reporting practices. they highlight value cross-modals synthesis understanding how nervous system, peripheral, pre-cortical, cortical areas, respond compensate inputs loss.

Язык: Английский

Persistence of Olfactory Dysfunction in Post CoVid-19 Patients Using Sniffin Sticks-A Prospective Study DOI Creative Commons

Priyanka Thangaraj,

Sowmya Gajapathy,

Jayita Poduval

и другие.

Bengal Journal of Otolaryngology and Head Neck Surgery, Год журнала: 2024, Номер 32(1), С. 37 - 42

Опубликована: Ноя. 29, 2024

INTRODUCTION This study is conducted to assess the Olfactory dysfunction (OD) of CoVid-19 recovered patients using ODOFIN Sniffin’ Sticks and analyze demographic features, duration recovery, co-morbidities/metabolic disorders associated with persistence OD in Post patients. MATERIALS AND METHODS Prospective observational was at our tertiary care hospital on 40 persistent OD. The olfaction assessed qualitatively sticks 6th, 10th, 12th weeks CoVid results documented analysed. RESULTS Total eligible were selected. 50% participants males 60% aged 18-38 years. 3 Diabetic Hypertensive. 37 had which 26 Hyposmia 11 Anosmia 6 CoVid. 22 14 8 10 12 There no association found between age, co-morbidities 6, (p>0.05). common among females be statistically significant (p<0.05). CONCLUSION Knowledge about time pattern recovery will essential counselling treating them.

Язык: Английский

Процитировано

0
An Epigenetic Locus Associated with Loss of Smell in COVID-19 DOI Creative Commons
Elif Sibel Aslan, Kenneth White,

Gülsen Meral

и другие.

Diagnostics, Год журнала: 2024, Номер 14(24), С. 2823 - 2823

Опубликована: Дек. 15, 2024

Background/Aim: Loss of smell, also known as anosmia, is a prevalent and often prolonged symptom following infection with SARS-CoV-2. While many patients regain olfactory function within weeks, significant portion experience persistent anosmia lasting over year post-infection. The underlying mechanisms responsible for this sensory deficit remain largely uncharacterized. Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 UGT2A2 genes that are linked to in COVID-19 patients. However, role epigenetic changes development persistence smell loss has not been well explored. In study, we aimed investigate alterations form DNA methylation UGT1A1 gene, which locus associated dysfunction Methods: We analysed patterns blood samples from two carefully matched cohorts 20 each, differentiated by their function—those normal (normosmia) those suffering (anosmia). were age sex minimize potential confounding factors. Results: Using quantitative analysis, found significantly lower levels group compared normosmia group, 14% decrease median values (p < 0.0001). These findings highlight epigenomic gene may contribute pathogenesis infection. Our results suggest status at could serve biomarker affected individuals. Conclusion: This study among first describe COVID-19, providing foundation future research into targeted interventions therapeutic strategies reversing anosmia. Further investigations involving larger additional loci help elucidate complex interaction between genetic, epigenetic, environmental factors influencing long-term impairment post-COVID-19.

Язык: Английский

Процитировано

0
SARS-CoV-2 neurotropism and other possible causes of olfactory disorders in COVID-19 DOI Open Access
Paweł Sowa, Adam Dadok, Monika Adamczyk‐Sowa

и другие.

Neurologia i Neurochirurgia Polska, Год журнала: 2023, Номер 57(1), С. 36 - 42

Опубликована: Фев. 20, 2023

Язык: Английский

Процитировано

1
Viral Shedding and Persistence of Anosmia and Ageusia in an Asymptomatic SARS-CoV-2 Infection DOI Open Access

Nikolaos Kintrilis

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Март 23, 2023

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in the region of Wuhan, China is responsible for ongoing pandemic disease-19 (COVID-19) that has been a part our life almost three years now. Although there have multiple reports prolonged viral shedding people with disease, lasting extended periods can occur patients less serious clinical insults or even asymptomatic individuals. Herein, we report case female patient that, although otherwise asymptomatic, remained positive on nasopharyngeal testing period, alongside persisting complaints anosmia and ageusia. may well one individuals to be infected Greek territory; followed up her long-term COVID sequelae from time proof infection until present day.

Язык: Английский

Процитировано

1
Deprivation-induced plasticity in the early central circuits of the rodent visual, auditory, and olfactory systems: a systematic review and meta-analysis of the literature DOI Creative Commons
Li Huang, Francesca Hardyman, Megan Edwards

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 5, 2023

Abstract Activity-dependent neuronal plasticity is crucial for animals to adapt dynamic sensory environments. Traditionally, research on activity dependent-plasticity has used deprivation approaches in animal models, and it focused its effects primary cortices. However, emerging evidence emphasizes the importance of activity-dependent both organs sub-cortical regions where cranial nerves relay information brain. Additionally, a critical question arises: do different modalities share common cellular mechanisms deprivation-induced at these central entry-points? Furthermore, does duration correlate with specific mechanisms? This study aims systematically review meta-analyse papers that investigated visual, auditory, or olfactory rodents. Specifically, explores consequences homologous first synapse after nerve: vision—lateral geniculate nucleus superior colliculus; audition— ventral dorsal cochlear nucleus; olfaction—olfactory bulb. The systematic search yielded 91 (39 vision, 22 audition, 30 olfaction), revealing significant heterogeneity publication trends, experimental methods inducing deprivation, measures plasticity, reporting, across three modalities. Nevertheless, despite methodological differences, commonalities emerged when correlating deprivation. Following short-term deprivations (up 1 day) all systems showed reduced levels increased disinhibition. Medium-term (1 day week) induced greater glial involvement synaptic remodelling. Long-term (over predominantly led macroscopic structural changes including tissue shrinkage apoptosis. These findings underscore standardizing methodologies reporting practices. they highlight value cross-modals synthesis understanding how nervous system, peripheral, pre-cortical, cortical areas, respond compensate inputs loss.

Язык: Английский

Процитировано

1