SARS-CoV-2 neurotropism and other possible causes of olfactory disorders in COVID-19

Neurologia i Neurochirurgia Polska, Journal Year: 2023, Volume and Issue: 57(1), P. 36 - 42

Published: Feb. 20, 2023

Language: Английский

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Viral Shedding and Persistence of Anosmia and Ageusia in an Asymptomatic SARS-CoV-2 Infection

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: March 23, 2023

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in the region of Wuhan, China is responsible for ongoing pandemic disease-19 (COVID-19) that has been a part our life almost three years now. Although there have multiple reports prolonged viral shedding people with disease, lasting extended periods can occur patients less serious clinical insults or even asymptomatic individuals. Herein, we report case female patient that, although otherwise asymptomatic, remained positive on nasopharyngeal testing period, alongside persisting complaints anosmia and ageusia. may well one individuals to be infected Greek territory; followed up her long-term COVID sequelae from time proof infection until present day.

Language: Английский

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Is Olfactory Testing a Useful Diagnostic Tool to Identify SARS-CoV-2 Infections Early? A Cross-Sectional and Longitudinal Analysis

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(9), P. 3162 - 3162

Published: April 27, 2023

Genesis and the prognostic value of olfactory dysfunction (OD) in COVID-19 remain partially described. The objective our study was to characterize OD during SARS-CoV-2 infection examine whether testing may be a useful tool clinical practice order early identify patients with infection.Olfactory function assessment objectively carried out using u-Smell-it® test. In cross-sectional part, we evaluated this test control cohort negative tested patients, who attended University Hospital Frankfurt between May 2021 March 2022. second longitudinal sensitivity specificity as diagnostic marker am Main, Germany infected their close contacts.Among 494 detected 45.7% found significantly associated male gender (p < 0.001), higher age cardiovascular pulmonary comorbidities 0.001; p = 0.03). Among 90 positive 65.6% smoking status 0.04 each). Prevalence severity were increased infections Delta variant (B.1.617.2) compared those Omicron (BA.1.1.529). Diagnostic for diagnosis 69% 64%, respectively.OD is common different prevalence rates observed variants. accuracy not high enough implement routine infection.

Language: Английский

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Deprivation-induced plasticity in the early central circuits of the rodent visual, auditory, and olfactory systems: a systematic review and meta-analysis of the literature

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 5, 2023

Abstract Activity-dependent neuronal plasticity is crucial for animals to adapt dynamic sensory environments. Traditionally, research on activity dependent-plasticity has used deprivation approaches in animal models, and it focused its effects primary cortices. However, emerging evidence emphasizes the importance of activity-dependent both organs sub-cortical regions where cranial nerves relay information brain. Additionally, a critical question arises: do different modalities share common cellular mechanisms deprivation-induced at these central entry-points? Furthermore, does duration correlate with specific mechanisms? This study aims systematically review meta-analyse papers that investigated visual, auditory, or olfactory rodents. Specifically, explores consequences homologous first synapse after nerve: vision—lateral geniculate nucleus superior colliculus; audition— ventral dorsal cochlear nucleus; olfaction—olfactory bulb. The systematic search yielded 91 (39 vision, 22 audition, 30 olfaction), revealing significant heterogeneity publication trends, experimental methods inducing deprivation, measures plasticity, reporting, across three modalities. Nevertheless, despite methodological differences, commonalities emerged when correlating deprivation. Following short-term deprivations (up 1 day) all systems showed reduced levels increased disinhibition. Medium-term (1 day week) induced greater glial involvement synaptic remodelling. Long-term (over predominantly led macroscopic structural changes including tissue shrinkage apoptosis. These findings underscore standardizing methodologies reporting practices. they highlight value cross-modals synthesis understanding how nervous system, peripheral, pre-cortical, cortical areas, respond compensate inputs loss.

Language: Английский

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Persisting anosmia after COVID-19 infection: The continuing mystery

Journal of Medical and Scientific Research, Journal Year: 2024, Volume and Issue: 12(02), P. 134 - 137

Published: April 2, 2024

Background: COVID-19 pandemic has had a massive impact on global health-care systems and economic stability. Smell taste dysfunction is now recognized as one of the cardinal symptoms COVID-19. Since prevalence olfactory in infection varies from place to place, this study was done find out infection, its persistence follow-up tertiary care centre situated Alappuzha (South India). Methods: The present hospital based descriptive study. 150 patients with Infection who presented during period 6 months were selected, their detailed history, clinical findings investigation results recorded proforma. Follow-up for 2 years. Results: Among 114 (76%) them dysfunction. There no significant difference gender or age distribution, those dysfunction, 88 (77.2%) faster recovery within weeks. On follow-up, there even after Conclusion: seen among much more than that described studies other places. long some matter needs further research bring causative factors. Keywords: COVID-19; Olfactory dysfunction; anosmia; prevalence;

Language: Английский

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