Exosome's role in ovarian disease pathogenesis and therapy; focus on ovarian cancer and failure DOI
Hashem O. Alsaab,

Bandar Almutairy,

Ali Othman Almobarki

и другие.

Journal of Reproductive Immunology, Год журнала: 2024, Номер 167, С. 104403 - 104403

Опубликована: Дек. 3, 2024

Язык: Английский

Exosomes: Key Factors in Ovarian Cancer Peritoneal Metastasis and Drug Resistance DOI Creative Commons
Ming Shao,

Yunran Gao,

Xiling Xu

и другие.

Biomolecules, Год журнала: 2024, Номер 14(9), С. 1099 - 1099

Опубликована: Сен. 2, 2024

Ovarian cancer remains a leading cause of death among gynecological cancers, largely due to its propensity for peritoneal metastasis and the development drug resistance. This review concentrates on molecular underpinnings these two critical challenges. We delve into role exosomes, nano-sized vesicles integral cellular communication, in orchestrating complex interactions within tumor microenvironment that facilitate metastatic spread thwart therapeutic efforts. Specifically, we explore how exosomes drive by promoting epithelial–mesenchymal transition mesothelial cells, altering extracellular matrix, supporting angiogenesis, which collectively enable dissemination cells across cavity. Furthermore, dissect mechanisms contribute emergence resistance, including sequestration expulsion chemotherapeutic agents, horizontal transfer resistance genes, modulation DNA repair apoptotic pathways. By shedding light exosome-mediated processes, underscore potential exosomal pathways as novel targets, offering hope more effective interventions against ovarian cancer’s relentless progression.

Язык: Английский

Процитировано

2
Global Research Trends in Liquid Biopsy for Ovarian Cancer from 1999 to 2023: A 25-Year Bibliometric Analysis DOI Creative Commons

Jixian Wan,

Zechuan Rao,

Huaichao Liu

и другие.

The Journal of Liquid Biopsy, Год журнала: 2024, Номер 5, С. 100158 - 100158

Опубликована: Май 24, 2024

Язык: Английский

Процитировано

1
Exosomal noncoding RNAs in gynecological cancers: implications for therapy resistance and biomarkers DOI Creative Commons

XU Chang-fen,

Peiyao Xu, Jiaqi Zhang

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Апрель 26, 2024

Gynecologic cancers, including ovarian cancer (OC), cervical (CC), and endometrial (EC), pose a serious threat to women's health quality of life due their high incidence lethality. Therapeutic resistance in tumors refers reduced sensitivity tumor cells therapeutic drugs or radiation, which compromises the efficacy treatment renders it ineffective. significantly contributes failure gynecologic tumors, although specific molecular mechanisms remain unclear. Exosomes are nanoscale vesicles released received by distinct kinds cells. contain proteins, lipids, RNAs closely linked origins functions. Recent studies have demonstrated that exosomal ncRNAs may be involved intercellular communication can modulate progression tumorigenesis, aggravation metastasis, microenvironment (TME), drug resistance. Besides, also potential become significant diagnostic prognostic biomarkers various diseases. In this paper, we reviewed biological roles as well explored acting liquid biopsy markers cancers.

Язык: Английский

Процитировано

0
Exosome's role in ovarian disease pathogenesis and therapy; focus on ovarian cancer and failure DOI
Hashem O. Alsaab,

Bandar Almutairy,

Ali Othman Almobarki

и другие.

Journal of Reproductive Immunology, Год журнала: 2024, Номер 167, С. 104403 - 104403

Опубликована: Дек. 3, 2024

Язык: Английский

Процитировано

0