Heliyon, Год журнала: 2024, Номер 10(22), С. e40473 - e40473
Опубликована: Ноя. 1, 2024
Arsenic can cause extensive toxic damage after entering the body of humans and animals by altering a variety events. As most common form methylation modification RNA in eukaryotic cells, N
Язык: Английский
Biomolecules, Год журнала: 2025, Номер 15(2), С. 247 - 247
Опубликована: Фев. 8, 2025
N6-methyladenosine (m6A) is the most prevalent internal chemical modification in eukaryotic messenger RNA (mRNA), significantly impacting its lifecycle through dynamic and reversible processes involving methyltransferase, demethylase, binding proteins. These regulate mRNA stability, splicing, nuclear export, translation, degradation. Programmed cell death (PCD), a tightly controlled process encompassing apoptosis, pyroptosis, ferroptosis, autophagy, necroptosis, plays crucial role maintaining cellular homeostasis, tissue development, function. Recently, m6A has emerged as significant research area due to regulating PCD implications cardiovascular diseases (CVDs). In this review, we delve into intricate relationship between various types modification, emphasizing their pivotal roles initiation progression of CVDs such myocardial ischemia-reperfusion (I/R), atherosclerosis (AS), pulmonary hypertension (PH), cardiomyopathy, doxorubicin (Dox)-induced cardiotoxicity (DIC), heart failure (HF), infarction (MI). Our findings underscore potential elucidating CVD pave new pathways for prevention treatment strategies.
Язык: Английский
Процитировано
1
Cancer Letters, Год журнала: 2024, Номер 591, С. 216867 - 216867
Опубликована: Апрель 7, 2024
Язык: Английский
Процитировано
5
Molecular Biomedicine, Год журнала: 2024, Номер 5(1)
Опубликована: Авг. 19, 2024
Abstract Transcription, RNA splicing, translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, play a crucial role in regulating The methyltransferase-like (METTL) family, constituent the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across cell nucleus, cytoplasm, mitochondria. Members METTL through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting replication, transcription, mRNA participate maintenance normal function promote disease development. This review primarily examines involvement family differentiation, mitochondrial function, its association with tumor formation, nervous system, cardiovascular diseases. Notably, intricately linked cellular particularly regulation translation factors. represent important molecules development associated patient immunity tolerance radiotherapy chemotherapy. Moreover, future research directions could include drugs antibodies targeting structural domains, utilizing nanomaterials carry miRNA corresponding mRNA. Additionally, precise mechanisms underlying interactions between factors remain be clarified.
Язык: Английский
Процитировано
4
Biomarker Research, Год журнала: 2024, Номер 12(1)
Опубликована: Сен. 17, 2024
Язык: Английский
Процитировано
4
Pathology - Research and Practice, Год журнала: 2025, Номер 267, С. 155837 - 155837
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217698 - 217698
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Cell Division, Год журнала: 2025, Номер 20(1)
Опубликована: Апрель 18, 2025
Язык: Английский
Процитировано
0
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189196 - 189196
Опубликована: Окт. 18, 2024
Язык: Английский
Процитировано
1
Cell Death and Disease, Год журнала: 2024, Номер 15(10)
Опубликована: Окт. 28, 2024
Abstract N 6 -Methyladenosine (m A) is an evolutionarily highly conserved epigenetic modification that affects eukaryotic RNAs, especially mRNAs, and m A commonly linked to tumor proliferation, progression, therapeutic resistance by participating in RNA metabolism. Autophagy intracellular degradation recycling biological process which cells remove damaged organelles, protein aggregates, other wastes, release nutrients maintain cell survival when energy scarce. Recent studies have shown plays a critical role the regulation of autophagy, affecting initiation formation assembly autophagosomes, lysosomal function regulating regulatory molecules involved autophagy. Moreover, autophagy can also affect expression three types regulators related A, turn levels their target genes via modification. Thus, form sophisticated network through mutual regulation, important progression resistance. In this manuscript, we reviewed effects on as well roles A-autophagy axis therapy Additionally, summarized value application prospects key diagnosis therapy.
Язык: Английский
Процитировано
1
Genes & Genomics, Год журнала: 2024, Номер unknown
Опубликована: Дек. 6, 2024
Язык: Английский
Процитировано
1