Experimental Neurology, Год журнала: 2024, Номер 385, С. 115093 - 115093
Опубликована: Дек. 19, 2024
Язык: Английский
Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)
Опубликована: Фев. 7, 2025
Mitochondrial dysfunction is a pivotal instigator of neuroinflammation, with mitochondrial DNA (mtDNA) leakage as critical intermediary. This review delineates the intricate pathways leading to mtDNA release, which include membrane permeabilization, vesicular trafficking, disruption homeostatic regulation, and abnormalities in dynamics. The escaped activates cytosolic sensors, especially cyclic gmp-amp synthase (cGAS) signalling inflammasome, initiating neuroinflammatory cascades via pathways, exacerbating spectrum neurological pathologies. therapeutic promise targeting discussed detail, underscoring necessity for multifaceted strategy that encompasses preservation homeostasis, prevention leakage, reestablishment dynamics, inhibition activation sensors. Advancing our understanding complex interplay between neuroinflammation imperative developing precision interventions disorders.
Язык: Английский
Процитировано
3
Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)
Опубликована: Март 4, 2025
The relationship between Alzheimer's disease (AD) and neuroimmunity has gradually begun to be unveiled. Emerging evidence indicates that cyclic GMP-AMP synthase (cGAS) acts as a cytosolic DNA sensor, recognizing damage-associated molecular patterns (DAMPs), inducing the innate immune response by activating stimulator of interferon genes (STING). Dysregulation this pathway culminates in AD-related neuroinflammation neurodegeneration. A substantial body mitochondria are involved critical pathogenic mechanisms AD, whose damage leads release mitochondrial (mtDNA) into extramitochondrial space. This leaked mtDNA serves DAMP, various pattern recognition receptors defense networks brain, including cGAS-STING pathway, ultimately leading an imbalance homeostasis. Therefore, modulation mtDNA-cGAS-STING restore neuroimmune homeostasis may offer promising prospects for improving AD treatment outcomes. In review, we focus on during stress activation pathway. Additionally, delve research progress further discuss primary directions potential hurdles developing targeted therapeutic drugs, gain deeper understanding pathogenesis provide new approaches its therapy.
Язык: Английский
Процитировано
1
Brain and Behavior, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 1, 2025
ABSTRACT Background The occurrence and development of postoperative cognitive dysfunction (POCD) are closely linked to neuroinflammation. This bibliometric analysis aims provide novel insights into the research trajectory, key topics, potential future trends in field neuroinflammation‐induced POCD. Methods Web Science Core Collection (WoSCC) database was searched identify publications from 2012 2023 on Bibliometric analysis, involving both statistical visual analyses, conducted using CiteSpace, VOSviewer, R software. Results Research POCD has exhibited an increasing trend over past 12 years. China had highest number publications, Nanjing Medical University most collaboration with other institutions, Zhiyi Zuo published author, Journal Neuroinflammation served as primary publication frequent keyword Keyword clustering indicated that predominant cluster is dexmedetomidine. Burst detection revealed delirium (POD), perioperative neurocognitive disorders (PND), apoptosis, epigenetic modifications were trends. Conclusions Our identified following areas associated POCD: anesthesia, surgery, dexmedetomidine, NLRP3 inflammasome, mechanism topics comprise POD, PND, modifications.
Язык: Английский
Процитировано
0
Tissue and Cell, Год журнала: 2025, Номер 93, С. 102739 - 102739
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
0
Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)
Опубликована: Янв. 22, 2025
Intervertebral disc degeneration (IDD) is a leading cause of low back pain, often linked to inflammation and pyroptosis in nucleus pulposus (NP) cells. The role Periostin (POSTN) IDD remains unclear. This study aims investigate the influence POSTN on NLRP3 inflammasome activation NP cells during IDD. IVD samples were collected from patients undergoing spinal surgery classified according Pfirrmann grading system. Human cultured treated with IL-1β induce pyroptotic phenotype. Western blotting, Immunofluorescence (IF), immunohistochemistry (IHC) assessed expression levels relevant proteins. Chromatin immunoprecipitation (ChIP) luciferase reporter assays verified binding IRF2 GSDMD promoters evaluated target genes. severity was using MRI histological analysis. Deletion significantly alleviated by suppressing activity found aggravate cell activating through NF-κB (P65) cGAS/STING signaling pathways. Furthermore, interacted Notch1 expression. identified as regulator at transcriptional level, contributing pyroptosis. also directly induced GSDMD, mediating Chemical screening Glucosyringic acid (GA) direct inhibitor POSTN, which delayed progression. elucidates pivotal highlights GA promising therapeutic candidate for These findings provide new insights into molecular mechanisms potential avenues treatment.
Язык: Английский
Процитировано
0
Molecular Neurobiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 151, С. 114269 - 114269
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138016 - 138016
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Translational Autoimmunity, Год журнала: 2025, Номер unknown, С. 100284 - 100284
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Journal of Nutrition, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0