Erythrocytes as Carriers: From Drug Delivery to Biosensors

Pharmaceutics, Год журнала: 2020, Номер 12(3), С. 276 - 276

Опубликована: Март 18, 2020

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug's action due to its gradual release from carrier; bioreactors with encapsulated enzymes performing necessary reactions, while remaining inaccessible immune system and plasma proteases; or tool for targeted drug target organs, primarily cells of reticuloendothelial system, liver spleen. To date, have been studied wide range drugs, such enzymes, antibiotics, anti-inflammatory, antiviral etc., diagnostic purposes (e.g. magnetic resonance imaging). The review focuses only on drugs loaded inside defines main lines research bioactive substances, well advantages limitations their application. Particular attention paid in vivo studies, opening-up potential clinical use into erythrocytes.

Язык: Английский

---

Drug-loaded erythrocytes: on the road toward marketing approval

Drug Design Development and Therapy, Год журнала: 2016, Номер unknown, С. 665 - 665

Опубликована: Фев. 1, 2016

Abstract: Erythrocyte drug encapsulation is one of the most promising therapeutic alternative approaches for administration toxic or rapidly cleared drugs. Drug-loaded erythrocytes can operate through three main mechanisms action: extension circulation half-life (bioreactor), slow release, specific organ targeting. Although clinical development erythrocyte carriers confronted with regulatory and process challenges, industrial expanding. The manufacture this type product be either centralized bedside based, different procedures are employed agents. major challenges successful industrialization include production scalability, validation, quality control released Advantages drawbacks manufacturing processes as well success key points discussed. Several entrapment technologies based on osmotic methods have been industrialized. Companies already achieved many critical stages, thus providing opportunity in future to cover a wide range diseases which effective therapies not currently available. Keywords: red blood cell, method, carrier, development, use

Язык: Английский

---

Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications

Acta Pharmacologica Sinica, Год журнала: 2021, Номер 42(7), С. 1040 - 1054

Опубликована: Март 26, 2021

Язык: Английский

---

Red blood cells: a potential delivery system

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 22, 2023

Abstract Red blood cells (RBCs) are the most abundant in body, possessing unique biological and physical properties. RBCs have demonstrated outstanding potential as delivery vehicles due to their low immunogenicity, long-circulating cycle, immune characteristics, exhibiting abilities. There been several developments understanding system of derivatives, they applied various aspects biomedicine. This article compared physiological characteristics RBCs, analyzed advantages systems, summarized existing practices Graphical

Язык: Английский

---

Structural, Spectroscopic (NMR, IR, and Raman), and DFT Investigation of the Self-Assembled Nanostructure of Pravastatin-LDH (Layered Double Hydroxides) Systems

Chemistry of Materials, Год журнала: 2012, Номер 24(8), С. 1415 - 1425

Опубликована: Март 9, 2012

Layered double hydroxide (LDH) nanocontainers, suitable as carriers for anionic drugs, were intercalated with Pravastatin drug using magnesium–aluminum and zinc–aluminum in a MII/Al molar ratio equal 2 different Al3+/Pravastatin ratios. Postsynthesis treatments used order to increase the materials crystallinity. Hybrid characterized by set of physical chemical techniques: elemental analysis, X-ray diffraction (XRD), mass coupled thermal analyses, vibrational infrared Raman spectroscopies, solid-state 13C nuclear magnetic resonance (NMR). Results interpreted light computational density functional theory (DFT) calculations performed Sodium assign data obtained LDH materials. XRD peaks LDH-Pravastatin material one-dimensional (1D) electron map pointed out bilayer arrangement interlayer region, where its associated carboxylate vicinal hydroxyl groups are close positive LDH. The structural organization observed stacked assembly containing unsymmetrical bulky monoanion seems be promoted self-assembling process, which local interactions maximized chloride ion cointercalation is required. It high similarity among NMR spectra Na-Pravastatin Those features indicate that intercalation preserves integrity. Spectroscopic techniques corroborate nature guest species their between inorganic layers. Changes related carboxylate, alcohol, olefinic moieties both after intercalation. Thus, ions forced arranged head tail through intermolecular hydrogen bonding adjacent organic species. decomposition profile hybrid samples distinct one salt, however, no visible behavior when anion sequestrated within gap.

Язык: Английский

---

Cell-based drug-delivery Platforms

Therapeutic Delivery, Год журнала: 2011, Номер 3(1), С. 25 - 41

Опубликована: Дек. 19, 2011

Cell systems have recently emerged as biological drug carriers, an interesting alternative to other such micro- and nano-particles. Different cells, carrier erythrocytes, bacterial ghosts genetically engineered stem dendritic cells been used. They provide sustained release specific delivery of drugs, enzymatic genetic material certain organs tissues. potential applications for the treatment cancer, HIV, intracellular infections, cardiovascular diseases, Parkinson's disease or in gene therapy. Carrier erythrocytes containing enzymes us L-asparaginase, drugs corticosteroids successfully used humans. Bacterial widely field vaccines also with doxorubicin. Genetically tested cancer immunotherapeutic vaccines. Although further research more clinical trials are necessary, cell-based platforms a promising strategy delivery.

Язык: Английский

---

<p>Combination of drugs and carriers in drug delivery technology and its development</p>

Drug Design Development and Therapy, Год журнала: 2019, Номер Volume 13, С. 1401 - 1408

Опубликована: Апрель 1, 2019

Abstract: The development of drug-loading technology will bring new and rapid to the treatment diseases. At present, drug delivery by nanoparticles, erythrocyte, platelet have been studied extensively. Compared with traditional anticancer drugs, nano-drugs shown many obvious advantages, disease based on nanotechnology a revolution in cancer treatment. Due its inherent biocompatibility, large load long half-life blood circulation, erythrocyte-inspired antibiotics, some drugs systems also entered clinical trial stage. there are relatively few studies platelets as carriers. It is necessary overcome shortcomings platelets, such easy activation, deformation, thrombosis, difficult preservation. There ways combine these carriers, each has own advantages disadvantages. seek best combination scheme increase loading reduce damage therapeutic components so more mature reliable methods for application technology. Several technologies their were described according various categories. carriers summarized better understanding practical application. Keywords: technology, carrier, combination, tumor

Язык: Английский

---

Intelligent berberine-loaded erythrocytes attenuated inflammatory cytokine productions in macrophages

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 23, 2024

Erythrocytes are impressive tools for drug delivery, especially to macrophages. Therefore, berberine was loaded into erythrocytes using both hypotonic pre-swelling and endocytosis methods target Physicochemical kinetic parameters of the resulting carrier cells, such as loading/release kinetics, osmotic fragility, hematological indices, were determined. Drug loading optimized study Taguchi experimental design lab experiments. Loaded targeted macrophages ZnCl

Язык: Английский

---

Carrier erythrocytes: recent advances, present status, current trends and future horizons

Expert Opinion on Drug Delivery, Год журнала: 2014, Номер 11(3), С. 433 - 447

Опубликована: Янв. 24, 2014

Carrier erythrocytes, thanks to their main advantages, including biocompatibility, biodegradability, immunocompatibility, simple and well-known structure physiology, availability for sampling versatility in loading use, have been studied as cellular carriers delivery of drugs other bioactive agents more than three decades. Based on this body knowledge recent advances field, with the help novel multidisciplinary sciences technologies, it seems that field is becoming renowned experiencing an outstanding turning point its developmental history.In trendy timely review, following a short historical review story erythrocytes from oxygen drug evaluation present status these biocarriers, current experimental, technological clinical trends, well future horizons, and, particular, translation-prone strategies, are going be discussed detail.Despite challenging history carrier they now stand closer use market entrance due unique advantages delivery, proven by recently reported success stories late-stage trials progresses made biotechnology, nanotechnology biomaterials fields. Translation-prone approaches, like vivo circulating or semiautomatic realistic study designs focusing needs not responded erythrocyte biology/fate-inspired design among trends being focused pioneer research groups active delivery.

Язык: Английский

---

Recent advancements in erythrocytes, platelets, and&nbsp;albumin as delivery systems

OncoTargets and Therapy, Год журнала: 2016, Номер unknown, С. 2873 - 2873

Опубликована: Май 1, 2016

In the past few years, nanomaterial-based drug delivery systems have been applied to enhance efficacy of therapeutics and alleviate negative effects through controlled targeting releasing agents. However, carriers can achieve high efficacy, even when modalities surface markers are introduced. Immunological problems also limited their wide applications. Biological systems, such as erythrocytes, platelets, albumin, extensively investigated because unique properties. this review, albumin described efficient systems. Their properties, applications, advantages, limitations in disease treatment explained. This review confirms that these be used facilitate a specific, biocompatible, smart delivery.

Язык: Английский

---