Osteoarthritis
(OA)
is
the
most
prevalent
degenerative
joint
disorder,
characterized
by
progressive
degradation,
pain,
and
diminished
mobility,
all
of
which
collectively
impair
patients'
quality
life
escalate
healthcare
expenditures.
Current
treatment
options
are
often
inadequate
due
to
limited
efficacy,
adverse
side
effects,
temporary
symptom
relief,
underscoring
urgent
need
for
more
effective
therapeutic
strategies.
Recent
advancements
in
nanomaterials
nanomedicines
offer
promising
solutions
improving
drug
bioavailability,
reducing
effects
providing
targeted
benefits.
This
review
critically
examines
pathogenesis
OA,
highlights
limitations
existing
treatments,
explores
latest
innovations
intelligent
design
OA
therapy,
with
an
emphasis
on
their
engineered
properties,
mechanisms,
translational
potential
clinical
application.
By
compiling
recent
findings,
this
work
aims
inspire
further
exploration
innovation
nanomedicine,
ultimately
advancing
development
personalized
therapies.
Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 429 - 444
Опубликована: Фев. 16, 2024
Osteoarthritis
(OA),
a
common
degenerative
disease,
is
characterized
by
high
disability
and
imposes
substantial
economic
impacts
on
individuals
society.
Current
clinical
treatments
remain
inadequate
for
effectively
managing
OA.
Organoids,
miniature
3D
tissue
structures
from
directed
differentiation
of
stem
or
progenitor
cells,
mimic
native
organ
functions.
They
are
useful
drug
testing
serve
as
active
grafts
repair.
However,
organoid
construction
requires
extracellular
matrix-like
scaffolds
cellular
growth.
Hydrogel
microspheres,
with
tunable
physical
chemical
properties,
show
promise
in
cartilage
engineering
replicating
the
natural
microenvironment.
Building
prior
work
SF-DNA
dual-network
hydrogels
regeneration,
we
developed
novel
RGD-SF-DNA
hydrogel
microsphere
(RSD-MS)
via
microfluidic
system
integrating
photopolymerization
self-assembly
techniques
then
modified
Pep-RGDfKA.
The
RSD-MSs
exhibited
uniform
size,
porous
surface,
optimal
swelling
degradation
properties.
Bioactive Materials,
Год журнала:
2024,
Номер
37, С. 378 - 392
Опубликована: Апрель 23, 2024
Posttraumatic
osteoarthritis
(PTOA)
patients
are
often
diagnosed
by
X-ray
imaging
at
a
middle-late
stage
when
drug
interventions
less
effective.
Early
PTOA
is
characterized
overexpressed
matrix
metalloprotease
13
(MMP13).
Herein,
we
constructed
an
integrated
diagnosis
and
treatment
micelle
modified
with
MMP13
enzyme-detachable,
cyanine
5
(Cy5)-containing
PEG,
black
hole
quencher-3
(BHQ3),
cRGD
ligands
loaded
siRNA
silencing
(siM13),
namely
ERMs@siM13.
ERMs@siM13
could
be
cleaved
in
the
diseased
cartilage
tissues
to
detach
PEG
shell,
causing
exposure.
Accordingly,
ligand
exposure
promoted
uptake
chondrocytes
binding
cell
surface
αvβ3
integrin,
increasing
intracellular
siM13
delivery
for
on-demand
downregulation.
Meanwhile,
Cy5
fluorescence
was
restored
detaching
from
BHQ3-containing
micelle,
precisely
reflecting
state.
In
particular,
intensity
of
generated
that
hinged
on
levels
reflect
severity,
enabling
physicians
adjust
therapeutic
regimen.
Finally,
murine
model,
diagnose
early-stage
PTOA,
perform
timely
interventions,
monitor
OA
progression
level
during
through
real-time
detection
MMP13.
Therefore,
represents
appealing
approach
theranostics.
Processes,
Год журнала:
2023,
Номер
11(9), С. 2696 - 2696
Опубликована: Сен. 8, 2023
Biomaterials
are
mostly
any
natural
and
synthetic
materials
which
compatible
from
a
biological
point
of
view
with
the
human
body.
widely
used
to
sustain,
increase,
reestablish
or
substitute
function
injured
tissue
organ
Additionally,
biomaterials
uninterruptedly
in
contact
body,
i.e.,
tissue,
blood
fluids.
For
this
reason,
an
essential
feature
is
their
biocompatibility.
Consequently,
review
summarizes
classification
different
types
based
on
origin,
as
ones.
Moreover,
advanced
applications
pharmaceutical
medical
domains
highlighted
specific
mechanical
physical
properties
biomaterials,
concerning
use.
The
high-priority
challenges
field
also
discussed,
especially
those
regarding
transfer
implementation
valuable
scientific
results
practice.
Abstract
Destruction
of
cartilage
due
to
the
abnormal
remodeling
subchondral
bone
(SB)
leads
osteoarthritis
(OA),
and
restoring
chondro‐bone
metabolic
homeostasis
is
key
treatment
OA.
However,
traditional
intra‐articular
injections
for
OA
cannot
directly
break
through
barrier
reach
SB.
In
this
study,
hydrothermal
method
used
synthesize
ultra‐small
size
(≈5
nm)
selenium‐doped
carbon
quantum
dots
(Se‐CQDs,
SC),
which
conjugated
with
triphenylphosphine
(TPP)
create
TPP‐Se‐CQDs
(SCT).
Further,
SCT
dynamically
complexed
hyaluronic
acid
modified
aldehyde
methacrylic
anhydride
(AHAMA)
construct
highly
permeable
micro/nano
hydrogel
microspheres
(SCT@AHAMA)
homeostasis.
vitro
experiments
confirmed
that
selenium
atoms
scavenged
reactive
oxygen
species
(ROS)
from
mitochondria
mononuclear
macrophages,
inhibited
osteoclast
differentiation
function,
suppressed
early
chondrocyte
apoptosis
maintain
a
balance
between
matrix
synthesis
catabolism.
vivo
further
demonstrated
delivery
system
osteoclastogenesis
H‐vessel
invasion,
thereby
regulating
initiation
process
inhibiting
degeneration
in
conclusion,
based
on
facilitate
efficient
penetration
articular
SB
regulate
metabolism
treatment.
Abstract
Osteoarthritis
(OA)
is
a
chronic
disease
that
causes
pain
and
disability
in
adults,
affecting
≈300
million
people
worldwide.
It
caused
by
damage
to
cartilage,
including
cellular
inflammation
destruction
of
the
extracellular
matrix
(ECM),
leading
limited
self‐repairing
ability
due
lack
blood
vessels
nerves
cartilage
tissue.
Organoid
technology
has
emerged
as
promising
approach
for
repair,
but
constructing
joint
organoids
with
their
complex
structures
special
mechanisms
still
challenging.
To
overcome
these
boundaries,
3D
bioprinting
allows
precise
design
physiologically
relevant
organoids,
shape,
structure,
mechanical
properties,
arrangement,
biological
cues
mimic
natural
In
this
review,
authors
will
introduce
structure
tissues,
summarize
key
procedures
propose
strategies
using
bioprinting.
The
also
discuss
challenges
organoids’
approaches
perspectives
on
future
applications,
opening
opportunities
model
tissues
response
treatment.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 24308 - 24319
Опубликована: Ноя. 17, 2023
Meniscus
injuries
are
associated
with
the
degeneration
of
cartilage
and
development
osteoarthritis
(OA).
It
is
challenging
to
protect
articular
improve
exercise
when
a
meniscus
injury
occurs.
Herein,
inspired
by
components
functions
meniscus,
we
developed
self-lubricating
friction-responsive
hydrogel
that
contains
nanoliposomes
loaded
diclofenac
sodium
(DS)
Kartogenin
(KGN)
for
anti-inflammation
regeneration.
When
was
injected
into
site,
drug-loaded
were
released
from
in
manner
reassembled
form
hydration
layers
lubricate
joints
during
movement.
Meanwhile,
DS
KNG
constantly
mitigate
inflammation
promote
Additionally,
this
exhibited
favorable
injectability,
mechanical
properties,
fatigue
resistance,
prolonged
degradation.
In
vivo
experiments
demonstrated
injection
effectively
improved
performance
protected
rats,
suggesting
it
as
potential
therapeutic
approach
meniscal
injuries.
Materials Today Chemistry,
Год журнала:
2024,
Номер
39, С. 102178 - 102178
Опубликована: Июль 1, 2024
Inflammatory
arthritis
is
a
growing
worldwide
concern,
afflicting
millions
of
individuals
and
leading
to
depreciating
quality
life,
significant
morbidity,
subsequent
healthcare
burden.
Conventional
therapies
for
inflammatory
often
hold
limitations,
including
systemic
cross-reactivities,
side
effects,
inadequate
management
inflammation.
Therefore,
"Smart"
stimuli-responsive
biomaterials
are
materialized
as
promising
theranostic
approaches
management.
These
designed
specific
external
internal
stimulation,
enabling
the
sustained
release
bioactive
therapeutic
agents
during
local
or
administration.
Stimuli-responsive
allow
precise
spatiotemporal
control
over
drug
release,
minimizing
exposure,
reducing
off-target
real-time
monitoring
pathological
conditions,
driving
potential
breakthrough
in
managing
arthritis.
Owing
this
prominence,
review
article
expounds
on
emerging
prospects
targeting
molecular
signatures
associated
with
intricately
elicit
minimal
no
contradictory
effects.
In
addition,
application
these
disease
progression
multi-stimuli-responsive
comprehended
show
progress
diagnosis
treatment.
This
"single-platted"
comprehensive
acquaintance
clinical-based
outcomes
navigates
microenvironment,
proposing
an
optimistic
avenue
personalized
effective
minimized
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(30)
Опубликована: Май 1, 2024
Abstract
Osteoarthritis
(OA),
a
prevalent
joint
disease
affecting
many
people
globally,
presents
significant
challenge
in
current
treatments,
which
often
only
manage
symptoms
without
halting
progression.
This
review
illuminates
novel
approaches
OA
therapy,
focusing
mainly
on
intra‐articular
injection
of
nanomaterials.
The
innovative
materials,
designed
to
either
mimic
or
augment
natural
lubrication,
show
promise
restoring
biomechanics
and
alleviating
pain.
delves
into
an
array
biomimetic
lubricants,
including
polymer
brush,
nanocomposite
hydrogel,
nanoparticles,
underscoring
their
roles
anti‐inflammation,
targeting,
cartilage
repair,
drug
delivery.
Furthermore,
the
potential
mesenchymal
stem
cells
differentiate
chondrocytes,
coupled
with
delivery
these
exosomes
via
nanomaterials,
has
promoted
cell
therapy
avenues
for
OA.
also
highlights
function
non‐coding
RNAs
such
as
miRNA,
siRNA,
circRNA,
lncRNA,
antisense
oligonucleotides
impeding
progression,
nanomaterials
facilitating
delivery,
thus
advanced
therapeutic
possibilities
immune
evasion
bone
proliferation.
Overall,
this
encapsulates
evolution
treatment
from
material
cell,
ultimately
gene
forecasting
future
where
evolve
toward
integrated,
personalized
diagnostics
therapeutics
Journal of Advanced Research,
Год журнала:
2024,
Номер
66, С. 329 - 347
Опубликована: Янв. 11, 2024
Bone
metabolism
can
maintain
the
normal
homeostasis
and
function
of
bone
tissue.
Once
balance
is
broken,
it
will
cause
osteoporosis,
osteoarthritis,
defects,
tumors,
or
other
diseases.
However,
such
orthopedic
diseases
still
have
many
limitations
in
clinical
treatment,
as
drug
restrictions,
tolerance,
side
effects,
implant
rejection.
review:
In
complex
therapy
regeneration,
extracellular
derivatives
become
a
promising
research
focus
to
solve
problems
metabolic
These
derivatives,
which
include
components
matrix,
growth
factors,
vesicles,
significant
therapeutic
potential.
It
has
advantages
good
biocompatibility,
low
immune
response,
dynamic
demand
for
The
purpose
this
review
provide
comprehensive
perspective
on
elucidate
intrinsic
properties
versatility
derivatives.
Further
discussion
them
innovative
advanced
materials
improving
effectiveness
regeneration
processes.
Key
scientific
concepts
review,
we
first
listed
types
functions
three
Then,
discussed
effects
different
cell
sources
metabolism.
Subsequently,
collected
applications
treatment
summarized
challenges
applications.
Finally,
prospected
novel
We
hope
that
understanding
new
solutions
